Giovanni Iolascon
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View article: Biomechanical and biological features of hyaluronic acid in combination with chondroitin and platelet rich plasma for regenerative medicine applications
Biomechanical and biological features of hyaluronic acid in combination with chondroitin and platelet rich plasma for regenerative medicine applications Open
Currently, one of the most common treatments for osteoarthritis (OA) is viscosupplementation using intra-articular injectable gels, often based on glycosaminoglycans (GAGs), specifically hyaluronic acid (HA) and, in some cases, chondroitin…
View article: Render to physiatrist the things that are physiatrist's. In Italy, the Supreme Court confirms that physiotherapy without medical diagnosis is unlawful practice of medicine: what about the rest of Europe?
Render to physiatrist the things that are physiatrist's. In Italy, the Supreme Court confirms that physiotherapy without medical diagnosis is unlawful practice of medicine: what about the rest of Europe? Open
View article: An Integrated Nutritional and Physical Activity Approach for Osteosarcopenia
An Integrated Nutritional and Physical Activity Approach for Osteosarcopenia Open
Osteoporosis is a skeletal disorder characterized by decreased bone strength, which leads to an increased risk of developing fractures. Interestingly, this metabolic disorder is often related to sarcopenia, defined as decreased muscle mass…
View article: Osteosarcopenic obesity: A systematic review and a call for consensus on definitions and diagnostic criteria
Osteosarcopenic obesity: A systematic review and a call for consensus on definitions and diagnostic criteria Open
These findings underscore the need for consensus guidelines that provide a standardized definition of OSO, diagnostic criteria with practical and clinically relevant cut-offs, and consistent methodologies. This will help identify the preva…
View article: Efficacy of extracorporeal shock wave therapy and nutraceutical supplementation in the treatment of lateral epicondylitis: a randomized controlled trial
Efficacy of extracorporeal shock wave therapy and nutraceutical supplementation in the treatment of lateral epicondylitis: a randomized controlled trial Open
Introduction Numerous scientific papers have compared different treatment options in the management of lateral epicondylitis. Our study evaluated the efficacy of focal extracorporeal shock wave treatment (ESWT) combined with an integrative…
View article: Development of a mobile APP to promote physical activity in individuals with knee osteoarthritis: the “Move for Knee”™ study protocol
Development of a mobile APP to promote physical activity in individuals with knee osteoarthritis: the “Move for Knee”™ study protocol Open
In modern society, physical activity is essential for maintaining both physical and mental health, particularly as technological advancements have contributed to a sedentary lifestyle. The World Health Organization recommends a minimum of …
View article: Transient osteoporosis of the hip and fatty liver disease: Case report and pathogenic hypothesis
Transient osteoporosis of the hip and fatty liver disease: Case report and pathogenic hypothesis Open
Transient osteoporosis of the hip is a rare, temporary condition characterized by hip pain and functional limitations, which can significantly reduce the quality of life. Bone marrow edema of the proximal femur, identified through magnetic…
View article: Physical exercise for primary sarcopenia: an expert opinion
Physical exercise for primary sarcopenia: an expert opinion Open
Sarcopenia is the age-related loss of skeletal muscle mass and function. Recently, research has focused on defining diagnostic criteria for this condition, now recognized as a muscle disease with a specific identifying code (ICD-10: M62.84…
View article: Multidisciplinary analysis of ancient human skeletal remains using computed tomography: A case study from Cumae, Italy
Multidisciplinary analysis of ancient human skeletal remains using computed tomography: A case study from Cumae, Italy Open
CT analysis provides detailed insights into bone integrity and pathologies, facilitating comprehensive anthropological examinations. Multidisciplinary collaboration is essential for accurate interpretations of ancient human remains. This s…
View article: Role for neurological and immunological resilience in the pathway of the aging muscle powerpenia: InCHIANTI study longitudinal results
Role for neurological and immunological resilience in the pathway of the aging muscle powerpenia: InCHIANTI study longitudinal results Open
The neuromuscular junction shows several degenerative changes with aging, resulting in a reduction of transmission efficacy. These changes, paired with low-grade chronic inflammation, were considered triggers of the aging muscle processes.…
View article: Evidence synthesis of health policy and systems research in rehabilitation: a protocol for Cochrane overviews of systematic reviews on delivery, governance, financial arrangements, and implementation strategies
Evidence synthesis of health policy and systems research in rehabilitation: a protocol for Cochrane overviews of systematic reviews on delivery, governance, financial arrangements, and implementation strategies Open
Cochrane Rehabilitation and the World Health Organization (WHO) Rehabilitation Program are collaborating to produce four Cochrane overviews of systematic reviews that synthesize the current evidence from health policy and systems research …
View article: Onco-rheumatology: from rags to riches, a transdisciplinary evolution
Onco-rheumatology: from rags to riches, a transdisciplinary evolution Open
With ongoing advancements in medicine, patient management has become increasingly complex, especially when multiple conditions intersect. The need for integrated, transdisciplinary approaches has never been more critical. This complexity a…
View article: Pain Management in Knee Osteoarthritis: Insights from an Exploratory Online Survey of Italian Patients and Physicians
Pain Management in Knee Osteoarthritis: Insights from an Exploratory Online Survey of Italian Patients and Physicians Open
Background: In Italy, knee osteoarthritis (KOA) accounts for over 5 million prevalent cases and requires long-term multidisciplinary management. The most frequent KOA symptom is pain. The aim of the survey is to provide a national overview…
View article: Role of Magnesium in Skeletal Muscle Health and Neuromuscular Diseases: A Scoping Review
Role of Magnesium in Skeletal Muscle Health and Neuromuscular Diseases: A Scoping Review Open
Magnesium (Mg) is a vital element for various metabolic and physiological functions in the human body, including its crucial role in skeletal muscle health. Hypomagnesaemia is frequently reported in many muscle diseases, and it also seems …
View article: The new hospital discharge form for inpatient rehabilitation in Italy: a step forward to promote the role of rehabilitation in the healthcare system
The new hospital discharge form for inpatient rehabilitation in Italy: a step forward to promote the role of rehabilitation in the healthcare system Open
The new HDF is expected to improve data collection, reduce local and regional disparities, allow better comparison of the performances of the structures, and ultimately enhance the quality and outcomes of rehabilitation care across the cou…
View article: Unraveling the joints: a narrative review of osteoarthritis.
Unraveling the joints: a narrative review of osteoarthritis. Open
Osteoarthritis (OA) is a chronic and progressive degenerative disease that affects joint structures, such as the hips, knees, and hands, involving the articular cartilage, subchondral bone, ligaments, capsule, and synovium. OA is character…
View article: Current Indications and Future Direction in Heat Therapy for Musculoskeletal Pain: A Narrative Review
Current Indications and Future Direction in Heat Therapy for Musculoskeletal Pain: A Narrative Review Open
Background: Musculoskeletal pain is a non-negligible multifaceted condition affecting more than 30% of the global population. Superficial heat therapy (HT), through increasing tissue temperatures, plays a role in increasing local metabolis…
View article: Overview of Cochrane Systematic Reviews for Rehabilitation Interventions in Individuals with Upper Limb Fractures: A Mapping Synthesis
Overview of Cochrane Systematic Reviews for Rehabilitation Interventions in Individuals with Upper Limb Fractures: A Mapping Synthesis Open
Background and Objectives. This overview of Cochrane systematic reviews (CSRs) reports on current evidence on the effectiveness of rehabilitation interventions for persons with upper limb fractures (ULFs), and the quality of the evidence. …
View article: Bone involvement in the early stages of Parkinson’s disease: a case–control study
Bone involvement in the early stages of Parkinson’s disease: a case–control study Open
Objective To evaluate the qualitative and quantitative alterations of bone tissue in patients with early-stage Parkinson’s disease (PD) and to measure the associations between bone mineral density (BMD), trabecular bone score (TBS) and phy…
View article: An Integrated Care Approach to Improve Well-Being in Breast Cancer Patients
An Integrated Care Approach to Improve Well-Being in Breast Cancer Patients Open
Background Breast cancer (BC) treatment has recently been revolutionized by the introduction of newer targeted agents, that helped tailoring therapies around the single patient. Along with increased survival rates, a careful evaluation of …
View article: Characterization of an Italian population with neurological disorders in a rehabilitation setting using ClinFIT
Characterization of an Italian population with neurological disorders in a rehabilitation setting using ClinFIT Open
Objective: To examine the functioning profile of people with neurological disorders who access rehabilitation services through ClinFIT Generic-30. Methods: The functioning profile of people with neurological disorders accessing rehabilitat…
View article: Current Indications and Future Direction in Heat Therapy for Musculoskeletal Pain: A Narrative Review
Current Indications and Future Direction in Heat Therapy for Musculoskeletal Pain: A Narrative Review Open
Background: Musculoskeletal pain is a non-negligible multifaceted condition affecting more than 30% of the global population. Superficial heat therapy (HT) through increasing tissues temperatures plays a role in increasing local metabolism…
View article: Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality—results from the Baltimore Longitudinal Study on Aging follow-up study
Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality—results from the Baltimore Longitudinal Study on Aging follow-up study Open
View article: The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs
The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs Open
Musculoskeletal disorders are characterized by several impairments, including pain, affecting muscles, bones, joints and adjacent connective tissue, resulting in temporary or permanent functional limitations and disability. Musculoskeletal…
View article: The sequential antifracturative treatment: a meta-analysis of randomized clinical trials
The sequential antifracturative treatment: a meta-analysis of randomized clinical trials Open
Background: Subjects with a fragility fracture have an increased risk of a new fracture and should receive effective strategies to prevent new events. The medium-term to long-term strategy should be scheduled by considering the mechanisms …
View article: Correction: Vassallo et al. Hyaluronic Acid-Based Injective Medical Devices: In Vitro Characterization of Novel Formulations Containing Biofermentative Unsulfated Chondroitin or Extractive Sulfated One with Cyclodextrins. Pharmaceuticals 2023, 16, 1429
Correction: Vassallo et al. Hyaluronic Acid-Based Injective Medical Devices: In Vitro Characterization of Novel Formulations Containing Biofermentative Unsulfated Chondroitin or Extractive Sulfated One with Cyclodextrins. Pharmaceuticals 2023, 16, 1429 Open
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View article: Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence
Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence Open
Aging induces a slow and progressive decrease in muscle mass and function, causing sarcopenia. Androgens control muscle trophism and exert important anabolic functions through the binding to the androgen receptor. Therefore, analysis of th…
View article: What We Should Expect from an Innovative Intra-Articular Hyaluronic Acid Product: Expert Opinion Based on a Comprehensive Review of the Literature
What We Should Expect from an Innovative Intra-Articular Hyaluronic Acid Product: Expert Opinion Based on a Comprehensive Review of the Literature Open
Background: Intra-articular hyaluronic acid (IAHA) products are often used in the treatment of adults with mild-to-moderate knee osteoarthritis (KOA). The International Symposium on Intra-Articular Treatment (ISIAT) convened a multidiscipl…
View article: Refracture following vertebral fragility fracture when bone fragility is not recognized: summarizing findings from comparator arms of randomized clinical trials
Refracture following vertebral fragility fracture when bone fragility is not recognized: summarizing findings from comparator arms of randomized clinical trials Open
View article: Calcifediol in patients with hip fractures
Calcifediol in patients with hip fractures Open
Vitamin D deficiency has a high prevalence in the elderly population. This condition can cause sarcopenia and osteoporomalacia, which are associated with an increased risk of falls and fractures, especially of the proximal femur. These fra…