Giovanni Lanza
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View article: KRAS Mutations in Colorectal Adenocarcinoma: Incidence and Association with Histological Features with Particular Reference to Gly12Asp in a Multicenter GIPAD Real-World Study
KRAS Mutations in Colorectal Adenocarcinoma: Incidence and Association with Histological Features with Particular Reference to Gly12Asp in a Multicenter GIPAD Real-World Study Open
Introduction: Colorectal cancer (CRC) is the third most frequent malignancy and the second cause of cancer-related death worldwide. CRC is characterized by morphologic and biological heterogeneity, and molecular profiling is required to se…
View article: Clinical application of synovial biopsy in noninflammatory and persistent inflammatory refractory rheumatoid arthritis
Clinical application of synovial biopsy in noninflammatory and persistent inflammatory refractory rheumatoid arthritis Open
Our findings demonstrate distinct synovial and clinical phenotypes in refractory RA. Although PIRRA appears driven by active synovial inflammation and immune cell infiltration, NIRRA involves predominantly pauci-immune/fibroid histology wi…
View article: Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells
Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells Open
Background: Renal cell carcinoma (RCC), the most common solid tumor of the kidney, accounts for approximately 3% of all malignancies and has a higher incidence in Western countries. The current frontline treatment for metastatic RCC (mRCC)…
View article: PML localization in tumor associated macrophages as a prognostic marker in triple negative breast cancer
PML localization in tumor associated macrophages as a prognostic marker in triple negative breast cancer Open
View article: A Radiomic-based model to predict the depth of myometrial invasion in endometrial cancer on ultrasound images
A Radiomic-based model to predict the depth of myometrial invasion in endometrial cancer on ultrasound images Open
In Europe, endometrial carcinoma was found to be the fourth most common tumor in the female population in 2022. The depth of myometrial invasion is a well-established and crucial prognostic risk factor in endometrial cancer patients and is…
View article: Addressing COVID-19 Screening Delays: The Impact of HPV Self-Sampling on Non-Attenders in a Cervical Cancer Screening Program
Addressing COVID-19 Screening Delays: The Impact of HPV Self-Sampling on Non-Attenders in a Cervical Cancer Screening Program Open
Background/Objectives: Self-sampling is recognized as a viable alternative to clinician-sampling for HPV primary screening. This study aimed to assess, within an Italian organized cervical cancer screening program, the acceptance and ease …
View article: Differential PML localization in tumor-associated macrophages reflects the inflammatory state and the prognosis of triple-negative breast cancer patients
Differential PML localization in tumor-associated macrophages reflects the inflammatory state and the prognosis of triple-negative breast cancer patients Open
Background Triple-negative breast cancer (TNBC) stands out as a particularly aggressive and metastatic subtype, defined by its absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. It's importan…
View article: ROLE OF THE MACHINE LEARNING–DERIVED HYPOTENSION INDEX (HPI) TO CONTAIN INTRAOPERATIVE HYPOTENSION DURING TRANSCATHETER EDGE TO EDGE REPAIR PROCEDURES
ROLE OF THE MACHINE LEARNING–DERIVED HYPOTENSION INDEX (HPI) TO CONTAIN INTRAOPERATIVE HYPOTENSION DURING TRANSCATHETER EDGE TO EDGE REPAIR PROCEDURES Open
Introduction Percutaneous endovascular valvular interventions can result in profound hemodynamic instability, elevated burden of intraoperative hypotension (IOH) and related postoperative complications: ischemic stroke, acute kidney injury…
View article: High-grade synovitis associates with clinical markers and response to therapy in chronic inflammatory arthritis: post hoc analysis of a synovial biomarkers prospective cohort study
High-grade synovitis associates with clinical markers and response to therapy in chronic inflammatory arthritis: post hoc analysis of a synovial biomarkers prospective cohort study Open
Background Inflammatory arthritis (IAs), such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA), are characterized by the presence of chronic synovitis. The Krenn’s synovitis score (KSS), a simple tool detectable by haematoxylin/e…
View article: Tofacitinib restores psoriatic arthritis fibroblast-like synoviocytes function via autophagy and mitochondrial quality control modulation
Tofacitinib restores psoriatic arthritis fibroblast-like synoviocytes function via autophagy and mitochondrial quality control modulation Open
The JAK inhibitor tofacitinib reduces the pro-invasive and pro-inflammatory properties of PsA FLS. Autophagy induction and mitochondrial quality control modulation by tofacitinib might contribute to FLS function restoration.
View article: Hsa-microRNA-1249-3p/Homeobox A13 axis modulates the expression of β-catenin gene in human epithelial cells
Hsa-microRNA-1249-3p/Homeobox A13 axis modulates the expression of β-catenin gene in human epithelial cells Open
Intercellular adhesion is a key function for epithelial cells. The fundamental mechanisms relying on epithelial cell adhesion have been partially uncovered. Hsa-microRNA-1249-3p (hsa-miR-1249-3p) plays a role in the epithelial mesenchymal …
View article: Table S1 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Table S1 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Supplementary Table
View article: Supplementary Data - Cases from Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF
Supplementary Data - Cases from Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF Open
in this supplentary data file cases are reported
View article: Figure S3 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Figure S3 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Supplementary Figure S3
View article: Figure S3 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Figure S3 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Supplementary Figure S3
View article: Data from Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF
Data from Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF Open
Purpose: The purpose of this investigation was to characterize Merkel cell carcinomas (MCC) arisen in patients affected by autoimmune diseases and treated with biologic drugs.Experimental Design: Serum samples from patients w…
View article: Data from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Data from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Purpose:BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1–V600E) or as dimers (class 2–codons 597/601), and RAS-dependent with impaired kinase activity (class 3–codons 594/596). Al…
View article: Table S1 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Table S1 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Supplementary Table
View article: Figure S1 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Figure S1 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Supplementary Figure S1
View article: Data from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Data from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Purpose:BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1–V600E) or as dimers (class 2–codons 597/601), and RAS-dependent with impaired kinase activity (class 3–codons 594/596). Al…
View article: Figure S2 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Figure S2 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Supplementary Figure S2
View article: Supplementary Data - Cases from Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF
Supplementary Data - Cases from Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF Open
in this supplentary data file cases are reported
View article: Figure S2 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Figure S2 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Supplementary Figure S2
View article: Data from Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF
Data from Merkel Cell Carcinomas Arising in Autoimmune Disease Affected Patients Treated with Biologic Drugs, Including Anti-TNF Open
Purpose: The purpose of this investigation was to characterize Merkel cell carcinomas (MCC) arisen in patients affected by autoimmune diseases and treated with biologic drugs.Experimental Design: Serum samples from patients w…
View article: Figure S1 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
Figure S1 from Class 1, 2, and 3 <i>BRAF</i>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization Open
Supplementary Figure S1
View article: Data from Frequent Aberrant Methylation of the <b><i>CDH4</i></b> Gene Promoter in Human Colorectal and Gastric Cancer
Data from Frequent Aberrant Methylation of the <b><i>CDH4</i></b> Gene Promoter in Human Colorectal and Gastric Cancer Open
Gene promoter methylation causes loss of tumor suppressor genes function in human cancer. Here, we show that the CDH4 gene, a member of the cadherin family encoding for R-cadherin, contains a CpG island located at the 5′ of the firs…
View article: Supplementary Table 1, Figures 1-4 from Oncogenic Role of <i>miR-483-3p</i> at the <i>IGF2/483</i> Locus
Supplementary Table 1, Figures 1-4 from Oncogenic Role of <i>miR-483-3p</i> at the <i>IGF2/483</i> Locus Open
Supplementary Table 1, Figures 1-4 from Oncogenic Role of miR-483-3p at the IGF2/483 Locus
View article: Supplementary Table 1, Figures 1-4 from Oncogenic Role of <i>miR-483-3p</i> at the <i>IGF2/483</i> Locus
Supplementary Table 1, Figures 1-4 from Oncogenic Role of <i>miR-483-3p</i> at the <i>IGF2/483</i> Locus Open
Supplementary Table 1, Figures 1-4 from Oncogenic Role of miR-483-3p at the IGF2/483 Locus
View article: Data from Oncogenic Role of <i>miR-483-3p</i> at the <i>IGF2/483</i> Locus
Data from Oncogenic Role of <i>miR-483-3p</i> at the <i>IGF2/483</i> Locus Open
hsa-mir-483 is located within intron 2 of the IGF2 locus. We found that the mature microRNA (miRNA) miR-483-3p is overexpressed in 100% of Wilms' tumors. In addition, colon, breast, and liver cancers exhibit high or ev…
View article: Supplementary Data from Frequent Aberrant Methylation of the <b><i>CDH4</i></b> Gene Promoter in Human Colorectal and Gastric Cancer
Supplementary Data from Frequent Aberrant Methylation of the <b><i>CDH4</i></b> Gene Promoter in Human Colorectal and Gastric Cancer Open
Supplementary Material and Methods, Results, 1 figure, and 1 table