Giovanni Luca Cipriano
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View article: Mutant Tau (P301L) Enhances Global Protein Translation in Differentiated SH-SY5Y Cells by Upregulating mTOR Signalling
Mutant Tau (P301L) Enhances Global Protein Translation in Differentiated SH-SY5Y Cells by Upregulating mTOR Signalling Open
Altered protein synthesis plays a key role in ageing and multiple neurodegenerative diseases. In Alzheimer’s disease and other tauopathies, the intracellular accumulation of hyperphosphorylated Tau disrupts several cellular processes, incl…
View article: Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair
Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair Open
Multiple Sclerosis (MS) therapies effectively modulate peripheral immune responses but largely fail to promote neural repair within the central nervous system. This review evaluates whether psychedelic compounds (PSYs), via 5-HT2A activati…
View article: Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair
Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair Open
Multiple Sclerosis (MS) therapies effectively modulate peripheral immune responses but largely fail to promote neural repair within the central nervous system. This review evaluates whether psychedelic compounds (PSYs), via 5-HT2A activati…
View article: Correlation of cognitive dysfunctions and diffusion tensor MRI measures in subjects with RRMS
Correlation of cognitive dysfunctions and diffusion tensor MRI measures in subjects with RRMS Open
Background Cognitive dysfunction is a common impairment observed in individuals with Multiple Sclerosis (MS), affecting key domains such as attention, information processing speed, memory, and executive functions. This deficit is typically…
View article: Correlation of cognitive dysfunctions and diffusion tensor MRI measures in subjects with RRMS
Correlation of cognitive dysfunctions and diffusion tensor MRI measures in subjects with RRMS Open
Background Cognitive dysfunction is a common impairment observed in individuals with Multiple Sclerosis (MS), affecting key domains such as attention, information processing speed, memory, and executive functions. This deficit is typically…
View article: Gene-Exercise Interactions in Amyloid Metabolism and Clearance: Implications for Alzheimer’s Disease
Gene-Exercise Interactions in Amyloid Metabolism and Clearance: Implications for Alzheimer’s Disease Open
Alzheimer’s disease (AD), the most prevalent form of dementia, poses a critical global health challenge as its incidence rises with aging populations. Despite extensive research into its genetic and molecular underpinnings, effective thera…
View article: CRISPR/Cas9 and iPSC-Based Therapeutic Approaches in Alzheimer’s Disease
CRISPR/Cas9 and iPSC-Based Therapeutic Approaches in Alzheimer’s Disease Open
Alzheimer’s disease (AD), the leading cause of dementia, remains poorly understood despite decades of intensive research, which continues to hinder the development of effective treatments. As a complex multifactorial disorder, AD lacks a c…
View article: Estrogen Receptors: A New Frontier in Alzheimer’s Disease Therapy
Estrogen Receptors: A New Frontier in Alzheimer’s Disease Therapy Open
Alzheimer’s disease (AD) is a long-term neurodegenerative condition that leads to the deterioration of neurons and synapses in the cerebral cortex, resulting in severe dementia. AD is significantly more prevalent in postmenopausal women, s…
View article: Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways
Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways Open
Multiple sclerosis (MS) is a degenerative condition characterized by axonal damage and demyelination induced by autoreactive immune cells that occur in the Central Nervous System (CNS). The interaction between epigenetic changes and geneti…