Giovanni Widmer
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View article: Decay of Food DNA in the Gastrointestinal Tract: Implications for Molecular Dietary Records
Decay of Food DNA in the Gastrointestinal Tract: Implications for Molecular Dietary Records Open
Background/Objectives: The widely recognized potential for biased responses to food frequency questionnaires and non-compliant self-reporting is motivating the search for alternative food intake records. The analysis of fecal DNA has been …
View article: Sarcocystosis in Farm Animals in Brazil: A One-Health Approach
Sarcocystosis in Farm Animals in Brazil: A One-Health Approach Open
Sarcocystosis is a parasitic infection caused by obligate intracellular coccidia, which infect humans, domestic animals, and wildlife. More than 200 Sarcocystis species have already been identified, but for many of these, the life cycle, p…
View article: Impact of predicted microbiota tryptophanase activity on Cryptosporidium parvum proliferation
Impact of predicted microbiota tryptophanase activity on Cryptosporidium parvum proliferation Open
Protozoa in the genus Cryptosporidium infect intestinal epithelial cells. The profile of the fecal microbiota has been shown to impact the proliferation of Cryptosporidium parvum in a mouse model of cryptosporidiosis and a reverse effect o…
View article: Prevalence of Potentially Zoonotic Endoparasites in Domestic Dog Puppies
Prevalence of Potentially Zoonotic Endoparasites in Domestic Dog Puppies Open
Despite the existence of therapeutic and prophylactic measures, gastrointestinal parasites are common in pets. Due to the zoonotic potential of some species, parasitic protozoa and helminths are of great importance to public health. In thi…
View article: Nebulization of 2% lidocaine has no detectable impact on the healthy equine respiratory microbiota
Nebulization of 2% lidocaine has no detectable impact on the healthy equine respiratory microbiota Open
Glucocorticosteroids remain the most common pharmaceutical approach for the treatment of equine asthma but can be associated with significant side effects, including respiratory microbiome alterations. The goal of the study was to assess t…
View article: Prevalence of Potentially Zoonotic Endoparasites in Domestic Dog Puppies
Prevalence of Potentially Zoonotic Endoparasites in Domestic Dog Puppies Open
Despite the existence of therapeutic and prophylactic measures, gastrointestinal parasites are common in pets. Due to the zoonotic potential of some species, parasitic protozoa and helminths are of great importance to public health. In thi…
View article: Ingestible Sensor Based on Fluorescent Gold Nanoparticles and Molecularly Imprinted Polymers on Thread for Localized Quantification of <i>Escherichia Coli</i> in the Gastrointestinal Tract
Ingestible Sensor Based on Fluorescent Gold Nanoparticles and Molecularly Imprinted Polymers on Thread for Localized Quantification of <i>Escherichia Coli</i> in the Gastrointestinal Tract Open
The small intestinal (SI) microbiota plays an important role in human health and disease. Current methods based on fecal analysis do not provide an accurate representation of the SI microbiome. This article introduces an ingestible sensor …
View article: Magnetically Activated Ingestible Pill with Archimedes Screw for On‐Demand Sampling of Intestinal Microbiome
Magnetically Activated Ingestible Pill with Archimedes Screw for On‐Demand Sampling of Intestinal Microbiome Open
Technologies capable of noninvasively sampling different locations in the gut upstream of the colon will enable new insights into the role of organ‐specific microbiomes on human health. Herein, an ingestible pill for the sampling of gut lu…
View article: Fecal microbiota impacts development of Cryptosporidium parvum in the mouse
Fecal microbiota impacts development of Cryptosporidium parvum in the mouse Open
The dependence of Cryptosporidium parasites on host cell metabolites suggests that the development of nutritional interventions to limit parasite proliferation should be feasible. Based on this concept, we are testing dietary interventions…
View article: A highly antigenic fragment within the zoonotic Cryptosporidium parvum Gp900 glycoprotein (Domain 3) is absent in human restricted Cryptosporidium species
A highly antigenic fragment within the zoonotic Cryptosporidium parvum Gp900 glycoprotein (Domain 3) is absent in human restricted Cryptosporidium species Open
We identified a fragment (Domain 3—D3) of the immunodominant sporozoite surface glycoprotein of the zoonotic parasite Cryptosporidium gp900, which is absent C . hominis and C . parvum anthroponosum . The fragment is highly antigenic and is…
View article: The Impact of Physical Effort on the Gut Microbiota of Long-Distance Fliers
The Impact of Physical Effort on the Gut Microbiota of Long-Distance Fliers Open
Flying pigeons (Columbia livia) are extensively studied for their physical endurance and superior sense of orientation. The extreme physical endurance of which these birds are capable creates a unique opportunity to investigate the possibl…
View article: Scalable cryopreservation of infectious Cryptosporidium hominis oocysts by vitrification
Scalable cryopreservation of infectious Cryptosporidium hominis oocysts by vitrification Open
Cryptosporidium hominis is a serious cause of childhood diarrhea in developing countries. The development of therapeutics is impeded by major technical roadblocks including lack of cryopreservation and simple culturing methods. This impact…
View article: Cryptosporidium proventriculi in Captive Cockatiels (Nymphicus hollandicus)
Cryptosporidium proventriculi in Captive Cockatiels (Nymphicus hollandicus) Open
Cockatiels (Nymphicus hollandicus) are among the most commonly sold psittacines pets. The aim of this study was to evaluate the occurrence of Cryptosporidium spp. in domestic N. hollandicus and identify risk factors for this infection. We …
View article: The association between fecal microbiota, age and endoparasitism in adult alpacas
The association between fecal microbiota, age and endoparasitism in adult alpacas Open
Endoparasitism is a major cause of morbidity and mortality in alpacas ( Lama pacos ), with growing emergence of anthelmintic resistance. The purpose of the study was to correlate nematode worm burden and selected host phenotypic characteri…
View article: Development of Two Mouse Models for Vaccine Evaluation against Cryptosporidiosis
Development of Two Mouse Models for Vaccine Evaluation against Cryptosporidiosis Open
Cryptosporidiosis was shown a decade ago to be a major contributor to morbidity and mortality of diarrheal disease in children in low-income countries. A serious obstacle to develop and evaluate immunogens and vaccines to control this dise…
View article: Effect of Caging on Cryptosporidium parvum Proliferation in Mice
Effect of Caging on Cryptosporidium parvum Proliferation in Mice Open
Cryptosporidiosis is an enteric infection caused by several protozoan species in the genus Cryptosporidium (phylum Apicomplexa). Immunosuppressed mice are commonly used to model this infection. Surprisingly, for a pathogen like Cryptospori…
View article: PASSIVE 3D-PRINTED FULLY ELASTIC PILL FOR SAMPLING OF GUT MICROBIOME
PASSIVE 3D-PRINTED FULLY ELASTIC PILL FOR SAMPLING OF GUT MICROBIOME Open
Sampling of gut microbiome upstream of the colon is challenging and expensive.Research has shown that ingestible devices are effective in sampling microbiome, however existing designs are complex and suffer from high levels of contaminatio…
View article: Assessment of clinical and microbiota responses to fecal microbial transplantation in adult horses with diarrhea
Assessment of clinical and microbiota responses to fecal microbial transplantation in adult horses with diarrhea Open
Background and aims Fecal microbial transplantation (FMT) is empirically implemented in horses with colitis to facilitate resolution of diarrhea. The purpose of this study was to assess FMT as a clinical treatment and modulator of fecal mi…
View article: Prevalence of Cryptosporidium infection in domestic cats from an urban area in Brazil
Prevalence of Cryptosporidium infection in domestic cats from an urban area in Brazil Open
We investigated the occurrence of Cryptosporidium oocysts shedding by domestic cats in an urban setting. The calculation of minimum sample size was based on an estimated prevalence of 10%, 5% absolute sampling error and a 5% significance l…
View article: Cryopreservation of infectious Cryptosporidium parvum oocysts achieved through vitrification using high aspect ratio specimen containers
Cryopreservation of infectious Cryptosporidium parvum oocysts achieved through vitrification using high aspect ratio specimen containers Open
Infection with protozoa of the genus Cryptosporidium is a leading cause of child morbidity and mortality associated with diarrhea in the developing world. Research on this parasite has been impeded by many technical limitations, including …
View article: The fecal microbiota of healthy donor horses and geriatric recipients undergoing fecal microbial transplantation for the treatment of diarrhea
The fecal microbiota of healthy donor horses and geriatric recipients undergoing fecal microbial transplantation for the treatment of diarrhea Open
In contrast to diet and farm location, age did not significantly affect the healthy equine fecal microbiota, indicating that both healthy geriatric and young-adult horses may serve as FMT donors. The fecal microbiota of horses with diarrhe…
View article: Update on <i>Cryptosporidium</i> spp.: highlights from the Seventh International <i>Giardia</i> and <i>Cryptosporidium</i> Conference
Update on <i>Cryptosporidium</i> spp.: highlights from the Seventh International <i>Giardia</i> and <i>Cryptosporidium</i> Conference Open
While cryptosporidiosis is recognized as being among the most common causes of human parasitic diarrhea in the world, there is currently limited knowledge on Cryptosporidium infection mechanisms, incomplete codification of diagnostic metho…
View article: Additional file 6 of The fecal microbiota of wild and captive raptors
Additional file 6 of The fecal microbiota of wild and captive raptors Open
Additional file 6: Table S2. Metadata of 46 raptors included in the study.
View article: Additional file 5 of The fecal microbiota of wild and captive raptors
Additional file 5 of The fecal microbiota of wild and captive raptors Open
Additional file 5: Table S1. Taxonomic classification of 16S sequences from 46 fecal microbiota.
View article: Data for: An Immunocompetent Rat Model of Infection with Cryptosporidium species, hominis and parvum
Data for: An Immunocompetent Rat Model of Infection with Cryptosporidium species, hominis and parvum Open
Data obtained from (qPCR and immunohistology) intratracheal infection of Cryptosporidium parvum or C. hominis sporozoites in rats.
View article: Deprivation of dietary fiber enhances susceptibility of mice to cryptosporidiosis
Deprivation of dietary fiber enhances susceptibility of mice to cryptosporidiosis Open
Based on our initial observations showing that mice consuming a probiotic product develop more severe cryptosporidiosis, we investigated the impact of other dietary interventions on the intracellular proliferation of Cryptosporidium parvum…
View article: Ingestible Osmotic Pill for In Vivo Sampling of Gut Microbiomes
Ingestible Osmotic Pill for In Vivo Sampling of Gut Microbiomes Open
An ingestible lab-on-a-pill device capable of sampling the gut microbiome in vivo is shown, as described in article number 1900053 by Sameer R. Sonkusale and co-workers. The lab-on-a-pill uses an osmotic pump to acquire the sample in the e…