Giovannina Barisciano
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View article: Selection of short <scp>Gadd45β</scp> ‐binding peptides through a synergistic computational and biophysical approach
Selection of short <span>Gadd45β</span> ‐binding peptides through a synergistic computational and biophysical approach Open
In this study, we explored the design of linear D‐tripeptides tailored to bind specific cavities of Gadd45β, chosen as a model protein target. To identify peptides that selectively interact with predicted binding sites, we combined computa…
View article: Combined SERS-Raman screening of HER2-overexpressing or silenced breast cancer cell lines
Combined SERS-Raman screening of HER2-overexpressing or silenced breast cancer cell lines Open
Background Breast cancer (BC) is a heterogeneous neoplasm characterized by several subtypes. One of the most aggressive with high metastasis rates presents overexpression of the human epidermal growth factor receptor 2 (HER2). A quantitati…
View article: Combined SERS-Raman screening of HER2-overexpressing or silenced breast cancer cell lines
Combined SERS-Raman screening of HER2-overexpressing or silenced breast cancer cell lines Open
Background Breast cancer (BC) is a heterogeneous neoplasm characterized by several subtypes. One of the most aggressive with high metastasis rates presents overexpression of the human epidermal growth factor receptor 2 (HER2). A quantitati…
View article: Raman and Surface Enhanced Raman spectroscopy analysis of breast cancer cell lines with different HER2 expression profiles
Raman and Surface Enhanced Raman spectroscopy analysis of breast cancer cell lines with different HER2 expression profiles Open
Assessing HER2 expression in breast cancer cells holds significant diagnostic and prognostic importance. Traditional methods like immunohistochemistry and in situ hybridization suffer from low sensitivity and misclassification rates. In th…
View article: Development of High-Loading Trastuzumab PLGA Nanoparticles: A Powerful Tool Against HER2 Positive Breast Cancer Cells
Development of High-Loading Trastuzumab PLGA Nanoparticles: A Powerful Tool Against HER2 Positive Breast Cancer Cells Open
TZPs exert more robust effects than free trastuzumab via a dual mode of action: TZPs are taken up by cells through an endocytosis mechanism and release the drug intracellularly for longer time. Additionally, the TZPs that remain in the ext…
View article: Transcriptomic Analysis of Colorectal Cancer Cells Treated with Oil Production Waste Products (OPWPs) Reveals Enrichment of Pathways of Mitochondrial Functionality
Transcriptomic Analysis of Colorectal Cancer Cells Treated with Oil Production Waste Products (OPWPs) Reveals Enrichment of Pathways of Mitochondrial Functionality Open
Oil production waste products (OPWPs) derive from olive mill and represent a crucial environmental problem due to their high polyphenolic content able to pollute the ground. One option to reduce the OPWPs’ environmental impact is to exploi…
View article: Loss of circadian gene Timeless induces EMT and tumor progression in colorectal cancer via Zeb1-dependent mechanism
Loss of circadian gene Timeless induces EMT and tumor progression in colorectal cancer via Zeb1-dependent mechanism Open
View article: The miR-27a/FOXJ3 Axis Dysregulates Mitochondrial Homeostasis in Colorectal Cancer Cells
The miR-27a/FOXJ3 Axis Dysregulates Mitochondrial Homeostasis in Colorectal Cancer Cells Open
miR-27a plays a driver role in rewiring tumor cell metabolism. We searched for new miR-27a targets that could affect mitochondria and identified FOXJ3, an apical factor of mitochondrial biogenesis. We analyzed FOXJ3 levels in an in vitro c…
View article: Correction: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer
Correction: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer
miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer Open