Girgis Obaid
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View article: Fine‐Tuning Photochemical Immunogenic Cell Death by a Panel of Verteporfin‐Lipid Nanoparticles: A Data‐Driven Approach
Fine‐Tuning Photochemical Immunogenic Cell Death by a Panel of Verteporfin‐Lipid Nanoparticles: A Data‐Driven Approach Open
Immunogenic cell death (ICD) is an immunostimulatory process that can be induced by light‐activated photosensitizers, but its mechanisms remain unclear, especially with lipid nanoparticle (LNP) formulations. In this study, a multivariate, …
View article: Photo-induced changes in tissue stiffness alter epithelial budding morphogenesis in the embryonic lung
Photo-induced changes in tissue stiffness alter epithelial budding morphogenesis in the embryonic lung Open
Extracellular matrix (ECM) stiffness has been shown to influence the differentiation of progenitor cells in culture, but a lack of tools to perturb the mechanical properties within intact embryonic organs has made it difficult to determine…
View article: Recent strides in macromolecular targeted photodynamic therapy for cancer
Recent strides in macromolecular targeted photodynamic therapy for cancer Open
The recent approval of Akalux® for antibody-targeted photodynamic therapy (PDT) in Japan (also known as photoimmunotherapy), and the recent approval of Cytalux® for folate-specific image guided surgery by the FDA have motivated the continu…
View article: Engineering photodynamics for treatment, priming and imaging
Engineering photodynamics for treatment, priming and imaging Open
View article: Automated polarized hyperspectral imaging (PHSI) for ex-vivo and in-vivo tissue assessment
Automated polarized hyperspectral imaging (PHSI) for ex-vivo and in-vivo tissue assessment Open
Polarized light interactions with biological tissues can reveal information regarding tissue structure, while spectral characteristics are closely related to tissue composition. An integration of both modalities in a compact system could b…
View article: Critical PDT theory II: Current concepts and indications
Critical PDT theory II: Current concepts and indications Open
View article: Orthotopic Models of Pancreatic Cancer to Study PDT
Orthotopic Models of Pancreatic Cancer to Study PDT Open
View article: Subcutaneous Xenograft Models for Studying PDT In Vivo
Subcutaneous Xenograft Models for Studying PDT In Vivo Open
View article: Photoimmunotherapy retains its anti-tumor efficacy with increasing stromal content in heterotypic pancreatic cancer spheroids
Photoimmunotherapy retains its anti-tumor efficacy with increasing stromal content in heterotypic pancreatic cancer spheroids Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by increased levels of desmoplasia that contributes to reduced drug delivery and poor treatment outcomes. In PDAC, the stromal content can account for up to 90%…
View article: Membrane composition is a functional determinant of NIR-activable liposomes in orthotopic head and neck cancer
Membrane composition is a functional determinant of NIR-activable liposomes in orthotopic head and neck cancer Open
Near-infrared (NIR)-activable liposomes containing photosensitizer (PS)-lipid conjugates are emerging as tunable, high-payload, and tumor-selective platforms for photodynamic therapy (PDT)-based theranostics. To date, the impact that the m…
View article: What NIR photodynamic activation offers molecular targeted nanomedicines: Perspectives into the conundrum of tumor specificity and selectivity
What NIR photodynamic activation offers molecular targeted nanomedicines: Perspectives into the conundrum of tumor specificity and selectivity Open
View article: Is tumor cell specificity distinct from tumor selectivity in vivo? A quantitative NIR molecular imaging analysis of nanoliposome targeting
Is tumor cell specificity distinct from tumor selectivity in vivo? A quantitative NIR molecular imaging analysis of nanoliposome targeting Open
The significance and ability for receptor targeted nanoliposomes (tNLs) to bind to their molecular targets in solid tumors in vivo has been questioned, particularly as the efficiency of their tumor accumulation and selectivity is no…
View article: A Combination of Visudyne and a Lipid‐anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer
A Combination of Visudyne and a Lipid‐anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer Open
A major objective in developing new treatment approaches for lethal tumors is to reduce toxicity to normal tissues while maintaining therapeutic efficacy. Photodynamic therapy ( PDT ) provides a mechanistically distinct approach to treat t…
View article: Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery
Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery Open
The emergence of fluorescently labeled therapeutic antibodies has given rise to molecular probes for image-guided surgery. However, the extraneous interstitial presence of an unbound and nonspecifically accumulated probe gives rise to fals…
View article: Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy
Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy Open
Photodynamic therapy (PDT) is a photochemistry based treatment modality that involves the generation of cytotoxic species through the interactions of a photosensitizer molecule with light irradiation of an appropriate wavelength. PDT is an…