Explanipedia

CORUM in 2024: protein complexes as drug targets Open

Ralph Steinkamp, George Tsitsiridis, Barbara Brauner, Corinna Montrone, Gisela Fobo , et al. · 2024

CORUM (https://mips.helmholtz-muenchen.de/corum/) is a public database that offers comprehensive information about mammalian protein complexes, including their subunits, functions and associations with human diseases. The newly released CO…

Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts Open

Mengya Shi, Siyu Han, Kristin Klier, Gisela Fobo, Corinna Montrone , et al. · 2023

Background Metabolic Syndrome (MetS) is characterized by risk factors such as abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), hypertension, and hyperglycemia, which contribute to the development o…

Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts Open

Mengya Shi, Siyu Han, Kristin Klier, Gisela Fobo, Corinna Montrone , et al. · 2023

Background Metabolic syndrome (MetS) consists of risk factors (abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL–C), hypertension, hyperglycemia) for cardiovascular disease and type 2 diabetes. Here, we…

Additional file 1 of Identification of candidate metabolite biomarkers for metabolic syndrome and its five components in population-based human cohorts Open

Mengya Shi, Siyu Han, Kristin Klier, Gisela Fobo, Corinna Montrone , et al. · 2023

Additional file 1: Table S1. Metabolite quantification and normalization in KORA F4. The table presents metabolite abbreviations, analyte classes, and biochemical names of 163 metabolites in columns first to third. Detecting rate of each m…

CORUM: the comprehensive resource of mammalian protein complexes–2022 Open

George Tsitsiridis, Ralph Steinkamp, Mădălina Giurgiu, Barbara Brauner, Gisela Fobo , et al. · 2022

The CORUM database has been providing comprehensive reference information about experimentally characterized, mammalian protein complexes and their associated biological and biomedical properties since 2007. Given that most catalytic and r…

Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy Open

Nadine Spielmann, Gregor Miller, Tudor I. Oprea, Chih‐Wei Hsu, Gisela Fobo , et al. · 2022

Figure 1.In Fig. 1f, due to a production error, the large panels for Ap4e1 -/-mutant and control were interchanged and have been restored.In Fig. 1d,

Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy Open

Nadine Spielmann, Gregor Miller, Tudor I. Oprea, Chih‐Wei Hsu, Gisela Fobo , et al. · 2022

Erratum To: COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms Open

Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert D. Phair , et al. · 2021

COVID‐19 Disease Map, a computational knowledge repository of virus‐host interaction mechanisms Open

Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert D. Phair , et al. · 2021

COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms Open

Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert D. Phair , et al. · 2021

COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms Open

Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert D. Phair , et al. · 2020

We describe a large-scale community effort to build an open-access, interoperable, and computable repository of COVID-19 molecular mechanisms - the COVID-19 Disease Map. We discuss the tools, platforms, and guidelines necessary for the dis…

CORUM: the comprehensive resource of mammalian protein complexes—2019 Open

Mădălina Giurgiu, Julian Reinhard, Barbara Brauner, Irmtraud Dunger-Kaltenbach, Gisela Fobo , et al. · 2018

CORUM is a database that provides a manually curated repository of experimentally characterized protein complexes from mammalian organisms, mainly human (67%), mouse (15%) and rat (10%). Given the vital functions of these macromolecular ma…

PhenoDis: a comprehensive database for phenotypic characterization of rare cardiac diseases Open

Angela Adler, Pia Kirchmeier, Julian Reinhard, Barbara Brauner, Irmtraud Dunger , et al. · 2018

This FAIRsharing record describes: PhenoDis is a manually annotated database providing symptomatic, genetic and imprinting information about rare cardiac diseases. PhenoDis is primarily concerned with the assignment of clinical symptoms to…

Systematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens Open

Xueping Liu, Hoeke A. Baarsma, Chung Hwee Thiam, Corinna Montrone, Barbara Brauner , et al. · 2016

Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes Open

Tao Xu, Stefan Brandmaier, Ana C. Messias, Christian Herder, Harmen H. M. Draisma , et al. · 2015

OBJECTIVE Metformin is used as a first-line oral treatment for type 2 diabetes (T2D). However, the underlying mechanism is not fully understood. Here, we aimed to comprehensively investigate the pleiotropic effects of metformin. RESEARCH D…

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