Daniel Aguilar
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View article: Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3 and 6-month post-infection
Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3 and 6-month post-infection Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused significant global morbidity since 2019. Long COVID, characterized by persistent symptoms after acute infection, may involve endothelial injury. We analyzed endothelia…
View article: Exploring the acceptability, appropriateness, feasibility and satisfaction of an implementation strategy for out-of-HOspital administration of the Long-Acting combination of cabotegravir and rilpivirine as an optional therapy for HIV in Spain (the HOLA study)—a hybrid implementation-effectiveness, phase IV, double-arm, open-label, multicentric study: study protocol
Exploring the acceptability, appropriateness, feasibility and satisfaction of an implementation strategy for out-of-HOspital administration of the Long-Acting combination of cabotegravir and rilpivirine as an optional therapy for HIV in Spain (the HOLA study)—a hybrid implementation-effectiveness, phase IV, double-arm, open-label, multicentric study: study protocol Open
Introduction The HOLA study is a 12-month randomised, hybrid implementation-effectiveness, phase IV, double-arm, open-label, multicentric study including virologically suppressed people living with HIV (PWH). HOLA, which started in Septemb…
View article: Insights into the burden of bacterial antimicrobial resistance (AMR) in the WHO Eastern Mediterranean Region: a crucial step towards evidence-informed and targeted public health interventions
Insights into the burden of bacterial antimicrobial resistance (AMR) in the WHO Eastern Mediterranean Region: a crucial step towards evidence-informed and targeted public health interventions Open
Introduction: Antimicrobial resistance (AMR) is a significant but very complex global health issue, making it difficult to accurately determine its full impact. This study aimed to provide the most detailed regional/national estimates of t…
View article: Homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional immunofluorescence
Homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional immunofluorescence Open
Metastatic prostate cancer (mPC) is enriched for homologous recombination repair (HRR) gene alterations, which have prognostic and predictive value. Routine clinical implementation of next-generation sequencing (NGS) is still limited. We i…
View article: IpaA reveals distinct modes of vinculin activation during<i>Shigella</i>invasion and cell-matrix adhesion
IpaA reveals distinct modes of vinculin activation during<i>Shigella</i>invasion and cell-matrix adhesion Open
Vinculin is a cytoskeletal linker strengthening cell adhesion. The Shigella IpaA invasion effector binds to vinculin to promote vinculin supra-activation associated with head-domain–mediated oligomerization. Our study investigates the impa…
View article: Author Correction: Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
Author Correction: Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease Open
View article: Distinction between rhinitis alone and rhinitis with asthma using interactomics
Distinction between rhinitis alone and rhinitis with asthma using interactomics Open
View article: Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease Open
View article: Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution
Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution Open
Extracellular vesicles (EVs) secreted by tumors are abundant in plasma, but their potential for interrogating the molecular features of tumors through multi-omic profiling remains widely unexplored. Genomic and transcriptomic profiling of …
View article: First Report of OXA-181-Producing <i>Enterobacterales</i> Isolates in Latin America
First Report of OXA-181-Producing <i>Enterobacterales</i> Isolates in Latin America Open
Reports of carbapenemase-producing Enterobacterales (CPE) isolates are increasing worldwide. Accurate detection of the β-lactamase OXA-181 (a variant of OXA-48) is important to initiate therapy and preventive measures in the clinic.
View article: IpaA reveals distinct modes of vinculin activation during<i>Shigella</i>invasion and cell-matrix adhesion
IpaA reveals distinct modes of vinculin activation during<i>Shigella</i>invasion and cell-matrix adhesion Open
Vinculin is a cytoskeletal linker strengthening cell adhesion. The Shigella IpaA invasion effector binds to vinculin to promote vinculin supra-activation associated with head-domain mediated oligomerization. Our study investigates the impa…
View article: Macrophage and neutrophil heterogeneity at single-cell spatial resolution in inflammatory bowel disease
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in inflammatory bowel disease Open
Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic inflammatory intestinal diseases that show a perplexing heterogeneity in manifestations and response to treatment. The molecular basis for this heterogeneity remains uncharacteri…
View article: Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways
Differences and Similarities between the Lung Transcriptomic Profiles of COVID-19, COPD, and IPF Patients: A Meta-Analysis Study of Pathophysiological Signaling Pathways Open
Coronavirus disease 2019 (COVID-19) is a pandemic respiratory disease associated with high morbidity and mortality. Although many patients recover, long-term sequelae after infection have become increasingly recognized and concerning. Amon…
View article: Randomized Controlled Trial Substudy of Cell-specific Mechanisms of Janus Kinase 1 Inhibition With Upadacitinib in the Crohn’s Disease Intestinal Mucosa: Analysis From the CELEST Study
Randomized Controlled Trial Substudy of Cell-specific Mechanisms of Janus Kinase 1 Inhibition With Upadacitinib in the Crohn’s Disease Intestinal Mucosa: Analysis From the CELEST Study Open
Background Janus kinase (JAK) inhibition shows promise for treatment of patients with moderate to severe Crohn’s disease. We aimed to provide mechanistic insights into the JAK1-selective inhibitor upadacitinib through a transcriptomics sub…
View article: Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure Open
View article: Ceramide launches an acute anti‐adhesion pro‐migration cell signaling program in response to chemotherapy
Ceramide launches an acute anti‐adhesion pro‐migration cell signaling program in response to chemotherapy Open
Chemotherapy has been reported to upregulate sphingomylinases and increase cellular ceramide, often linked to the induction to cell death. In this work, we show that sublethal doses of doxorubicin and vorinostat still increased cellular ce…
View article: Whole transcriptional analysis identifies markers of B, T and plasma cell signaling pathways in the mesenteric adipose tissue associated with Crohn’s disease
Whole transcriptional analysis identifies markers of B, T and plasma cell signaling pathways in the mesenteric adipose tissue associated with Crohn’s disease Open
View article: Understanding allergic multimorbidity within the non-eosinophilic interactome
Understanding allergic multimorbidity within the non-eosinophilic interactome Open
Our results support the existence of differentiated multimorbidity mechanisms between asthma, dermatitis and rhinitis at cell type level, as well as mechanisms common to distinct cell types. These results will help understanding the biolog…
View article: Therapeutic effects of soluble guanylate cyclase stimulation on pulmonary hemodynamics and emphysema development in guinea pigs chronically exposed to cigarette smoke
Therapeutic effects of soluble guanylate cyclase stimulation on pulmonary hemodynamics and emphysema development in guinea pigs chronically exposed to cigarette smoke Open
We have analyzed the effect of the soluble guanylate cyclase (sGC) stimulator BAY 41-2272 in a therapeutic intervention in guinea pigs chronically exposed to cigarette smoke (CS). The effects of sGC stimulation on respiratory function, pul…
View article: Cell adhesion promoted by a unique <i>Shigella</i> IpaA vinculin- and talin-binding site
Cell adhesion promoted by a unique <i>Shigella</i> IpaA vinculin- and talin-binding site Open
During Shigella cell invasion, the IpaA effector targets the focal adhesion protein vinculin through three vinculin-binding sites (VBSs). Here, we report that IpaA VBS3 also binds to talin. The 2.5 Å resolution crystal structure indicates …
View article: Genetic and functional characterization of disease associations explains comorbidity
Genetic and functional characterization of disease associations explains comorbidity Open
View article: The <i>Shigella</i> type <scp>III</scp> effector IpgD recodes Ca <sup>2+</sup> signals during invasion of epithelial cells
The <i>Shigella</i> type <span>III</span> effector IpgD recodes Ca <sup>2+</sup> signals during invasion of epithelial cells Open
View article: Computational analysis of multimorbidity between asthma, eczema and rhinitis
Computational analysis of multimorbidity between asthma, eczema and rhinitis Open
These results strongly support the existence of an allergic multimorbidity cluster between asthma, eczema and rhinitis, and suggest that type 2 signaling pathways represent a relevant multimorbidity mechanism of allergic diseases. Furtherm…
View article: Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis Open
Nature Communications 7: Article number: 12460 (2016); Published: 23 August 2016; Updated: 10 October 2016. The HTML version of this Article incorrectly duplicated the authors S. Louis Bridges, Lindsey Criswell, Larry Moreland, Lars Klares…
View article: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis Open