Gisselle N. Medina
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View article: The pathogenesis of foot-and-mouth disease virus: current understandings and knowledge gaps
The pathogenesis of foot-and-mouth disease virus: current understandings and knowledge gaps Open
View article: Interferon-stimulated gene MCL1 inhibits foot-and-mouth disease virus replication by modulating mitochondrial dynamics and autophagy
Interferon-stimulated gene MCL1 inhibits foot-and-mouth disease virus replication by modulating mitochondrial dynamics and autophagy Open
Interferons (IFNs) and the IFN-stimulated genes (ISGs) that they induce are effective in reducing the replication of foot and mouth disease virus (FMDV). The use of a high-throughput ISG screen identified the ISG myeloid cell leukemia 1 (M…
View article: Differential mosaicism of recombinant foot-and-mouth disease viruses resulting from heterologous superinfection of cattle
Differential mosaicism of recombinant foot-and-mouth disease viruses resulting from heterologous superinfection of cattle Open
Evidence from both field and experimental studies suggests that recombination is a common feature in the evolution of foot-and-mouth disease virus (FMDV). Recent studies have demonstrated that heterologous superinfection of cattle persiste…
View article: Virulence and Immune Evasion Strategies of FMDV: Implications for Vaccine Design
Virulence and Immune Evasion Strategies of FMDV: Implications for Vaccine Design Open
Foot-and-mouth disease (FMD) is globally recognized as a highly economically devastating and prioritized viral disease affecting livestock. Vaccination remains a crucial preventive measure against FMD. The improvement of current vaccine pl…
View article: Antiviral activity of bovine type III interferon against bovine viral diarrhea virus is greatly reduced in bovine turbinate cells due to limited expression of IFN lambda receptor 1 (IL-28Rα)
Antiviral activity of bovine type III interferon against bovine viral diarrhea virus is greatly reduced in bovine turbinate cells due to limited expression of IFN lambda receptor 1 (IL-28Rα) Open
Introduction The antiviral activity of recombinant bovine interferon lambda 3 (bovIFN-λ3) against bovine viral diarrhea virus (BVDV) has been demonstrated in vitro in Madin-Darby bovine kidney cells (MDBK) and in vivo in cattle. However, a…
View article: Parallel single B cell transcriptomics to elucidate pig B cell repertoire
Parallel single B cell transcriptomics to elucidate pig B cell repertoire Open
Pork is the most widely consumed meat on the planet, placing swine health as a critical factor for both the world economy and the food industry. Infectious diseases in pigs not only threaten these sectors but also raise zoonotic concerns, …
View article: Prophylactic treatment with PEGylated bovine IFNλ3 effectively bridges the gap in vaccine-induced immunity against FMD in cattle
Prophylactic treatment with PEGylated bovine IFNλ3 effectively bridges the gap in vaccine-induced immunity against FMD in cattle Open
Foot-and-mouth disease (FMD) is a vesicular disease of cloven-hoofed animals with devastating economic implications. The current FMD vaccine, routinely used in enzootic countries, requires at least 7 days to induce protection. However, FMD…
View article: Characterization, Directed Evolution, and Targeting of DNA Virus-Encoded RNA Capping Enzymes Using Phenotypic Yeast Platforms
Characterization, Directed Evolution, and Targeting of DNA Virus-Encoded RNA Capping Enzymes Using Phenotypic Yeast Platforms Open
The constant and the sudden emergence of zoonotic human and animal viruses is a significant threat to human health, the world economy, and the world food supply. This has necessitated the development of broad-spectrum therapeutic strategie…
View article: Exploring the Molecular Basis of Vesicular Stomatitis Virus Pathogenesis in Swine: Insights from Expression Profiling of Primary Macrophages Infected with M51R Mutant Virus
Exploring the Molecular Basis of Vesicular Stomatitis Virus Pathogenesis in Swine: Insights from Expression Profiling of Primary Macrophages Infected with M51R Mutant Virus Open
Vesicular stomatitis virus (VSV) is an emergent virus affecting livestock in the US. Previously, using a recombinant VSV carrying the M51R mutation in the matrix protein (rNJ0612NME6-M51R), we evaluated the pathogenesis of this virus in pi…
View article: Deoptimization of FMDV P1 Region Results in Robust Serotype-Independent Viral Attenuation
Deoptimization of FMDV P1 Region Results in Robust Serotype-Independent Viral Attenuation Open
Foot-and-mouth disease (FMD), caused by the FMD virus (FMDV), is a highly contagious disease of cloven-hoofed livestock that can have severe economic impacts. Control and prevention strategies, including the development of improved vaccine…
View article: Evaluation of Potential In Vitro Recombination Events in Codon Deoptimized FMDV Strains
Evaluation of Potential In Vitro Recombination Events in Codon Deoptimized FMDV Strains Open
Codon deoptimization (CD) has been recently used as a possible strategy to derive foot-and-mouth disease (FMD) live-attenuated vaccine (LAV) candidates containing DIVA markers. However, reversion to virulence, or loss of DIVA, from possibl…
View article: Mutation of FMDV Lpro H138 residue drives viral attenuation in cell culture and in vivo in swine
Mutation of FMDV Lpro H138 residue drives viral attenuation in cell culture and in vivo in swine Open
The foot-and-mouth disease virus (FMDV) leader proteinase (L pro ) is a papain like protease that cleaves the viral polyprotein and several host factors affecting host cell translation and induction of innate immunity. Introduction of L pr…
View article: <scp>DDX60</scp> selectively reduces translation off viral type <scp>II</scp> internal ribosome entry sites
<span>DDX60</span> selectively reduces translation off viral type <span>II</span> internal ribosome entry sites Open
View article: Foot-and-Mouth Disease Virus Interserotypic Recombination in Superinfected Carrier Cattle
Foot-and-Mouth Disease Virus Interserotypic Recombination in Superinfected Carrier Cattle Open
Viral recombination contributes to the emergence of novel strains with the potential for altered host range, transmissibility, virulence, and immune evasion. For foot-and-mouth disease virus (FMDV), cell culture experiments and phylogeneti…
View article: Antiviral DExD/H-box helicase 60 selectively inhibits translation from type II internal ribosome entry sites
Antiviral DExD/H-box helicase 60 selectively inhibits translation from type II internal ribosome entry sites Open
During viral infection, competition ensues between viruses and their host cells to control the protein synthesis machinery. In response, certain host defense proteins globally limit mRNA translation. However, this is also detrimental for h…
View article: An adventitious agent-free clonal cell line that is highly susceptible to foot -and-mouth disease virus
An adventitious agent-free clonal cell line that is highly susceptible to foot -and-mouth disease virus Open
View article: Use of Protein Pegylation to Prolong the Antiviral Effect of IFN Against FMDV
Use of Protein Pegylation to Prolong the Antiviral Effect of IFN Against FMDV Open
Interferons (IFNs) are considered the first line of defense against viral diseases. Due to their ability to modulate immune responses, they have become an attractive therapeutic option to control virus infections. In fact, like many other …
View article: Use of Synonymous Deoptimization to Derive Modified Live Attenuated Strains of Foot and Mouth Disease Virus
Use of Synonymous Deoptimization to Derive Modified Live Attenuated Strains of Foot and Mouth Disease Virus Open
Foot-and-mouth disease (FMD) is one of the most economically important viral diseases that can affect livestock. In the last 70 years, use of an inactivated whole antigen vaccine has contributed to the eradication of disease from many deve…
View article: Use of IFN-Based Biotherapeutics to Harness the Host Against Foot-And-Mouth Disease
Use of IFN-Based Biotherapeutics to Harness the Host Against Foot-And-Mouth Disease Open
Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of cloven-hoofed animals that severely constrains international trade of livestock and animal products. Currently, disease control measures include broad surveillance, e…
View article: Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression
Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression Open
The type I interferon response is an important innate antiviral pathway. Recognition of viral RNA by RIG-I-like receptors (RLRs) activates a signaling cascade that leads to type I interferon (IFN-α/β) gene transcription. Multiple proteins …
View article: Impairment of the DeISGylation Activity of Foot-and-Mouth Disease Virus Lpro Causes Attenuation <i>In Vitro</i> and <i>In Vivo</i>
Impairment of the DeISGylation Activity of Foot-and-Mouth Disease Virus Lpro Causes Attenuation <i>In Vitro</i> and <i>In Vivo</i> Open
In this study, we identified an aromatic hydrophobic residue in foot-and-mouth disease virus (FMDV) leader proteinase (Lpro) (W105) that is involved in the interaction with ISG15. Mutation in Lpro W105 (A12-LproW105A) resulted in reduced d…
View article: Index
Index Open
View article: The Different Tactics of Foot-and-Mouth Disease Virus to Evade Innate Immunity
The Different Tactics of Foot-and-Mouth Disease Virus to Evade Innate Immunity Open
Like all pathogens, foot-and-mouth disease virus (FMDV) is recognized by the immune system inducing a heightened immune response mainly mediated by type I and type III IFNs. To overcome the strong antiviral response induced by these cytoki…
View article: Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation
Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation Open
The picornavirus foot-and-mouth disease virus (FMDV) is a notorious animal pathogen that puts a major economic burden on the global livestock industry. Outbreaks have significant consequences for animal health and product safety. Like many…
View article: The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)P2-binding site that targets Gag to the cell periphery
The matrix domain of the Gag protein from avian sarcoma virus contains a PI(4,5)P2-binding site that targets Gag to the cell periphery Open
The Gag protein of avian sarcoma virus (ASV) lacks an N-myristoyl (myr) group, but contains structural domains similar to those of HIV-1 Gag. Similarly to HIV-1, ASV Gag accumulates on the plasma membrane (PM) before egress; however…
View article: Adenovirus-vectored foot-and-mouth disease vaccine confers early and full protection against FMDV O1 Manisa in swine
Adenovirus-vectored foot-and-mouth disease vaccine confers early and full protection against FMDV O1 Manisa in swine Open
View article: Foot-and-mouth disease vaccines
Foot-and-mouth disease vaccines Open
View article: Evaluation of a Fiber-Modified Adenovirus Vector Vaccine against Foot-and-Mouth Disease in Cattle
Evaluation of a Fiber-Modified Adenovirus Vector Vaccine against Foot-and-Mouth Disease in Cattle Open
Novel vaccination approaches against foot-and-mouth disease (FMD) include the use of replication-defective human adenovirus type 5 (Ad5) vectors that contain the capsid-encoding regions of FMD virus (FMDV). Ad5 containing serotype A24 caps…
View article: Synonymous Deoptimization of Foot-and-Mouth Disease Virus Causes Attenuation <i>In Vivo</i> while Inducing a Strong Neutralizing Antibody Response
Synonymous Deoptimization of Foot-and-Mouth Disease Virus Causes Attenuation <i>In Vivo</i> while Inducing a Strong Neutralizing Antibody Response Open
Codon bias deoptimization has been previously used to successfully attenuate human pathogens, including poliovirus, respiratory syncytial virus, and influenza virus. We have applied a similar technology to deoptimize the capsid-coding regi…