Gitasha Chand
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View article: PD-L1 imaging with [99mTc]NM-01 SPECT/CT is associated with metabolic response to pembrolizumab with/without chemotherapy in advanced lung cancer
PD-L1 imaging with [99mTc]NM-01 SPECT/CT is associated with metabolic response to pembrolizumab with/without chemotherapy in advanced lung cancer Open
Background Programmed death-ligand 1 (PD-L1) immunohistochemistry is a predictive biomarker for anti-PD-(L)1 therapy in non-small cell lung cancer (NSCLC). It is not a reliable predictor of clinical benefit with non-invasive imaging provid…
View article: The effects of anti-PD-1 therapy on programmed death-ligand 1 expression and glucose metabolism of normal organs in patients with advanced non-small cell lung cancer
The effects of anti-PD-1 therapy on programmed death-ligand 1 expression and glucose metabolism of normal organs in patients with advanced non-small cell lung cancer Open
Objectives To investigate how anti-PD-1 treatment affects both Programmed Death-Ligand 1 (PD-L1) expression and glucose metabolism within normal tissues of advanced non-small cell lung cancer (NSCLC) patients using a dual SPECT/CT and PET/…
View article: [99mTc]-labelled anti-Programmed Death-Ligand 1 single-domain antibody SPECT/CT: a novel imaging biomarker for myocardial PD-L1 expression
[99mTc]-labelled anti-Programmed Death-Ligand 1 single-domain antibody SPECT/CT: a novel imaging biomarker for myocardial PD-L1 expression Open
Background Myocardial programmed death-ligand 1 (PD-L1) expression is implicated in immune checkpoint inhibitor (ICI)-associated myocarditis. Measurement of myocardial PD-L1 expression may have potential use as a mechanistic and predictive…
View article: P1 <sup>99m</sup>Tc-single domain PD-l1 antibody (NM01): a novel imaging biomarker for non-invasive myocardial PD-l1 expression
P1 <sup>99m</sup>Tc-single domain PD-l1 antibody (NM01): a novel imaging biomarker for non-invasive myocardial PD-l1 expression Open
Objective Immune checkpoint inhibitors have revolutionized the care of cancer patients and involve blockade of the PD-L1 receptor. Myocardial PD-L1 expression has been implicated in mice models in myocarditis and autoimmune dilated cardiom…
View article: Early Phase I Study of a <sup>99m</sup>Tc-Labeled Anti–Programmed Death Ligand-1 (PD-L1) Single-Domain Antibody in SPECT/CT Assessment of PD-L1 Expression in Non–Small Cell Lung Cancer
Early Phase I Study of a <sup>99m</sup>Tc-Labeled Anti–Programmed Death Ligand-1 (PD-L1) Single-Domain Antibody in SPECT/CT Assessment of PD-L1 Expression in Non–Small Cell Lung Cancer Open
Immunotherapy with checkpoint inhibitor programmed cell death 1 (PD-1)/programmed death ligand-1 (PD-L1) antibodies demonstrates improvements in treatment of advanced non-small cell lung cancer. Treatment stratification depends on immunohi…
View article: SPECT/CT imaging of chemotherapy-induced tumor apoptosis using <sup>99m</sup>Tc-labeled dendrimer-entrapped gold nanoparticles
SPECT/CT imaging of chemotherapy-induced tumor apoptosis using <sup>99m</sup>Tc-labeled dendrimer-entrapped gold nanoparticles Open
Non-invasive imaging of apoptosis in tumors induced by chemotherapy is of great value in the evaluation of therapeutic efficiency. In this study, we report the synthesis, characterization, and utilization of radionuclide technetium-99m (99…