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View article: Quantitative Phosphoproteomics of the Angiotensin AT <sub>2</sub> -Receptor Signaling Network Identifies HDAC1 (Histone-Deacetylase-1) and p53 as Mediators of Antiproliferation and Apoptosis
Quantitative Phosphoproteomics of the Angiotensin AT <sub>2</sub> -Receptor Signaling Network Identifies HDAC1 (Histone-Deacetylase-1) and p53 as Mediators of Antiproliferation and Apoptosis Open
Background: Angiotensin AT 2 -receptor signaling is atypical for a G-protein coupled receptor and incompletely understood. To obtain novel insights into AT 2 -receptor signaling, we mapped changes in the phosphorylation status of the entir…
View article: Normal-range urinary albumin excretion associates with blood pressure and renal electrolyte handling in pregnancy
Normal-range urinary albumin excretion associates with blood pressure and renal electrolyte handling in pregnancy Open
Albuminuria in the pathological range is a significant predictor of preeclampsia. In healthy persons, high normal urinary albumin predicts a later incidence of hypertension and is associated with salt sensitivity of blood pressure. We hypo…
View article: Is urinary excretion of plasminogen associated with development of pre-eclampsia? An observational, explorative case–control study
Is urinary excretion of plasminogen associated with development of pre-eclampsia? An observational, explorative case–control study Open
Objectives Pre-eclampsia (PE) is characterised by renal glomerular endotheliosis and injury to the glomerular filtration barrier with proteinuria. Patients with PE display aberrant filtration of the plasma proenzyme plasminogen which is ac…