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View article: No changes in weight, body composition or metabolic parameters after the switch to dolutegravir and lamivudine compared to continued treatment with dolutegravir, abacavir and lamivudine for virologically suppressed HIV infection (The AVERTAS trial)
No changes in weight, body composition or metabolic parameters after the switch to dolutegravir and lamivudine compared to continued treatment with dolutegravir, abacavir and lamivudine for virologically suppressed HIV infection (The AVERTAS trial) Open
Continuing or discontinuing abacavir for 48 weeks was associated with modest gains in weight that did not differ between groups. Similarly, fat distribution, or metabolic parameters were comparable between groups.
View article: Prospective screening for monkeypox infection among men who have sex with men at an infectious diseases outpatient clinic in Copenhagen, Denmark
Prospective screening for monkeypox infection among men who have sex with men at an infectious diseases outpatient clinic in Copenhagen, Denmark Open
Since 2022, over 102,000 cases of mpox clade IIb have been reported worldwide, primarily among men who have sex with men. Key risk factors include human immunodeficiency virus (HIV) infection and the use of HIV pre-exposure prophylaxis (Pr…
View article: Pneumocystis Pneumonia—Is it Still a Threat Among People With Human Immunodeficiency Virus (HIV)? A Danish HIV Cohort Study
Pneumocystis Pneumonia—Is it Still a Threat Among People With Human Immunodeficiency Virus (HIV)? A Danish HIV Cohort Study Open
Background We aimed to examine pneumocystis pneumonia (PCP) risk and mortality among people with human immunodeficiency virus (HIV), and associations with (1) time after HIV diagnosis, (2) calendar time, and (3) CD4 cell count. Methods Fro…
View article: Prospective screening for monkeypox infection among men who have sex with men at an infectious diseases’ outpatient clinic in Copenhagen, Denmark
Prospective screening for monkeypox infection among men who have sex with men at an infectious diseases’ outpatient clinic in Copenhagen, Denmark Open
Since 2022, over 102,000 cases of mpox clade IIb have been reported worldwide, primarily affecting men who have sex with men. Key risk factors include the use of HIV pre-exposure prophylaxis (PrEP) and HIV infection. In Denmark, the smallp…
View article: Risk of Tuberculosis After Achieving HIV Virological Suppression on Antiretroviral Therapy: A Danish Nationwide Prospective Cohort Study
Risk of Tuberculosis After Achieving HIV Virological Suppression on Antiretroviral Therapy: A Danish Nationwide Prospective Cohort Study Open
Background In countries with low tuberculosis burden, the risk of tuberculosis in people with human immunodeficiency virus (HIV; PWH) once HIV virological suppression is achieved is not fully understood. Methods In a nationwide cohort, we …
View article: Survival among people with HIV and their families in Denmark 1995–2021: a nationwide population-based cohort study
Survival among people with HIV and their families in Denmark 1995–2021: a nationwide population-based cohort study Open
View article: Pre-exposure prophylaxis against HIV infection
Pre-exposure prophylaxis against HIV infection Open
Pre-exposure prophylaxis (PrEP) decreases the risk for HIV transmission in high-risk populations. PrEP has been available in Denmark since 2019 and consists of antiretroviral drugs in a combination tablet taken daily or on demand. The effe…
View article: Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022 Open
Background Pre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about risk compensation, potentially impacting the expansion of PrEP programmes. Aim W…
View article: Corrigendum to “Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study” [International Journal of Infectious Diseases, 108 (2021), 582-587]
Corrigendum to “Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study” [International Journal of Infectious Diseases, 108 (2021), 582-587] Open
The authors regret that Table 2 had been mistakenly made with display of Odds Ratios (OR). The correct column heading should have been Incidence Rate Ratios (IRR). Please see revised table below:Table 2Risk factors associated with invasive…
View article: Survival Among Persons with HIV and Their Families – a Nationwide, Population-Based Cohort Study, Denmark, 1995-2021
Survival Among Persons with HIV and Their Families – a Nationwide, Population-Based Cohort Study, Denmark, 1995-2021 Open
View article: Pre-hospital symptoms associated with acute bacterial meningitis differs between children and adults
Pre-hospital symptoms associated with acute bacterial meningitis differs between children and adults Open
Community acquired bacterial meningitis (CABM) is a medical emergency requiring timely appropriate action. More knowledge about pre-hospital symptoms is needed. Retrospective observational study of pre-hospital management in patients with …
View article: Risk of Depression in People With Human Immunodeficiency Virus: A Nationwide Population-based Matched Cohort Study
Risk of Depression in People With Human Immunodeficiency Virus: A Nationwide Population-based Matched Cohort Study Open
Background Human immunodeficiency virus (HIV) infection is associated with depression. However, previous studies have not addressed familial factors. Methods Nationwide, population-based, matched cohort study of people with HIV (PWH) in De…
View article: Prospective screening for monkeypox infection among users of HIV pre-exposure prophylaxis (PrEP) in Denmark
Prospective screening for monkeypox infection among users of HIV pre-exposure prophylaxis (PrEP) in Denmark Open
Introduction During the 2022 outbreak of mpox (previously called monkeypox), which primarily affected men who have sex with men (MSM), testing was mainly limited to individuals with symptoms of infection. Although sporadic cases of mpox co…
View article: Predictors of serological non-response to the 13-valent pneumococcal conjugate vaccine followed by the 23-valent polysaccharide vaccine among adults living with HIV
Predictors of serological non-response to the 13-valent pneumococcal conjugate vaccine followed by the 23-valent polysaccharide vaccine among adults living with HIV Open
Less than half of our study population achieved anti-pneumococcal seroprotective levels following PCV13 and PPV23 immunization. Low pre-vaccination GMC levels were associated with non-response. Further research is required to optimize vacc…
View article: Factors associated with treatment delay and outcome in community acquired bacterial meningitis
Factors associated with treatment delay and outcome in community acquired bacterial meningitis Open
Treatment delay is a common problem associated with 30-day mortality in CABM. Awareness of CABM in undiagnosed patients is vital to achieve timely initiation of appropriate treatment. Special care should be shown for patients suspected of …
View article: Observational cohort study of rilpivirine (RPV) utilization in Europe
Observational cohort study of rilpivirine (RPV) utilization in Europe Open
View article: Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease
Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease Open
View article: Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia
Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia Open
ClinicalTrials.gov Identifier: NCT04509973 and ctri.nic.in Identifier: CTRI/2020/10/028731.
View article: Delayed diagnosis of tuberculosis in persons living with HIV in Eastern Europe: associated factors and effect on mortality—a multicentre prospective cohort study
Delayed diagnosis of tuberculosis in persons living with HIV in Eastern Europe: associated factors and effect on mortality—a multicentre prospective cohort study Open
View article: Tuberculosis incidence and mortality in people living with human immunodeficiency virus: a Danish nationwide cohort study
Tuberculosis incidence and mortality in people living with human immunodeficiency virus: a Danish nationwide cohort study Open
View article: High Mortality Among Patients With Severe COVID-19 and Do-not-intubate Orders Despite Use of Remdesivir and Dexamethasone
High Mortality Among Patients With Severe COVID-19 and Do-not-intubate Orders Despite Use of Remdesivir and Dexamethasone Open
Background Moderate to severe respiratory distress among patients with coronavirus disease 2019 (COVID-19) is associated with a high mortality. Dexamethasone and remdesivir were introduced in the second wave of COVID-19 in Denmark. Methods…
View article: Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial
Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial Open
View article: Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study
Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study Open
Objectives: Neisseria meningitidis serogroup W incidence has increased. Mortality associated with serogroup W has been higher than for other serogroups. Here we report epidemiological characteristics and risks of poor outcomes associated w…
View article: Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014–15
Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014–15 Open
View article: Longer-Term Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide Versus Emtricitabine and Tenofovir Disoproxil Fumarate for HIV-1 Pre-Exposure Prophylaxis: Week 96 Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial
Longer-Term Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide Versus Emtricitabine and Tenofovir Disoproxil Fumarate for HIV-1 Pre-Exposure Prophylaxis: Week 96 Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial Open
View article: Soluble urokinase plasminogen activator receptor (suPAR) is lower in disease-free patients but cannot rule out incident disease in patients with suspected cancer
Soluble urokinase plasminogen activator receptor (suPAR) is lower in disease-free patients but cannot rule out incident disease in patients with suspected cancer Open
suPAR was significantly lower in disease-free individuals compared to patients with cancer or other conditions, but the PPV was not sufficiently high to terminate further clinical investigation with appropriate safety. Elevated suPAR may b…
View article: Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men
Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men Open
These data support the theory that the natural neutralizing antibody response to HIV infection may not be the controlling factor in protecting against a subsequent HIV challenge.
View article: Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules
Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules Open
View article: Risk of skin cancer in patients with HIV: A Danish nationwide cohort study
Risk of skin cancer in patients with HIV: A Danish nationwide cohort study Open
View article: Inflammatory biomarkers and cancer: CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer
Inflammatory biomarkers and cancer: CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer Open
In Denmark, patients with serious nonspecific symptoms and signs of cancer (NSSC) are referred to the diagnostic outpatient clinics (DOCs) where an accelerated cancer diagnostic program is initiated. Various immunological and inflammatory …