Giulia Calafato
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View article: ESR1 analysis of liquid biopsy in breast cancer, one-year routine experience of an Italian clinical referral center
ESR1 analysis of liquid biopsy in breast cancer, one-year routine experience of an Italian clinical referral center Open
ESR1 mutations are detectable in approximately one-third of ER+/HER2- metastatic patients undergoing liquid biopsy. NGS platforms allow for sensitive and in-depth analysis, highlighting co-mutations of potential clinical and therapeutic re…
View article: Somatic genetic alterations in the development and progression in thyroid tumors of follicular cells
Somatic genetic alterations in the development and progression in thyroid tumors of follicular cells Open
Thyroid cancer is the most prevalent endocrine malignancy. Distinct genetic alterations drive the development and progression of thyroid tumors of follicular cells with remarkable genotype–phenotype correlation. In most tumors of follicula…
View article: Patient-Derived Organoid Biobanks for Translational Research and Precision Medicine: Challenges and Future Perspectives
Patient-Derived Organoid Biobanks for Translational Research and Precision Medicine: Challenges and Future Perspectives Open
Over the past decade, patient-derived organoids (PDOs) have emerged as powerful in vitro models that closely recapitulate the histological, genetic, and functional features of their parental primary tissues, representing a ground-breaking …
View article: Comparative Efficacy of Ribosome-Inactivating Protein-Containing Immunotoxins in 2D and 3D Models of Sarcoma
Comparative Efficacy of Ribosome-Inactivating Protein-Containing Immunotoxins in 2D and 3D Models of Sarcoma Open
Sarcomas are very complex and clinically challenging mesenchymal tumors. Although the standard therapeutic approach has improved the 5-year survival rate, many patients experience local relapses and/or distant metastases. To improve patien…
View article: Comparative Analysis of Commercial and Home-Made Media on RSPO1/S6R Axis in Organoids with Different Wnt Backgrounds: A Methodological Guide for the Selection of Intestinal Patient-Derived Organoids Culture Media
Comparative Analysis of Commercial and Home-Made Media on RSPO1/S6R Axis in Organoids with Different Wnt Backgrounds: A Methodological Guide for the Selection of Intestinal Patient-Derived Organoids Culture Media Open
WNT3A is an intestinal ligand triggering the Wnt/β-catenin (Wnt) pathway, which can be enhanced by R-spondin 1 (RSPO1) through the RSPO1–LGR axis or antagonized by the adenomatous polyposis coli (APC) protein supporting β-catenin-degradati…
View article: Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention
Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention Open
Background Wnt/β-catenin signalling impairment accounts for 85% of colorectal cancers (CRCs), including sporadic and familial adenomatous polyposis (FAP) settings. An altered PI3K/mTOR pathway and gut microbiota also contribute to CRC carc…
View article: Antibody Conjugates for Sarcoma Therapy: How Far along Are We?
Antibody Conjugates for Sarcoma Therapy: How Far along Are We? Open
Sarcomas are one of the most difficult type of cancer to manage and treat because of their extremely heterogeneous molecular and morphological features. Despite the progress made over the years in the establishment of standard protocols fo…
View article: Ricin: An Ancient Story for a Timeless Plant Toxin
Ricin: An Ancient Story for a Timeless Plant Toxin Open
The castor plant (Ricinus communis L.) has been known since time immemorial in traditional medicine in the pharmacopeia of Mediterranean and eastern ancient cultures. Moreover, it is still used in folk medicine worldwide. Castor bean has b…
View article: Ricin: An Ancient Story for a Timeless Plant Toxin
Ricin: An Ancient Story for a Timeless Plant Toxin Open
The castor plant (Ricinus communis L.) has been known since time immemorial in traditional medicine in the pharmacopeia of Mediterranean and eastern ancient cultures. Moreover, it is still used in folk medicine worldwide. Castor bean has b…