Explanipedia

A Practical Approach for Optimizing Ocular Surface Status Before Cataract Surgery to Improve Visual Outcomes and Reduce the Risk of Postoperative Dry Eye Open

Giulia Coco, Elisabeth M. Messmer, Christopher E. Starr, José Álvaro Pereira Gomes, Sihem Lazreg , et al. · 2025

Clinical Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Uveal Melanoma: A Narrative Review Open

Mario Troisi, Livio Vitiello, Filippo Lixi, Mihaela Madalina Timofte Zorila, Giulia Abbinante , et al. · 2025

Uveal melanoma is the most common primary intraocular malignancy in adults, most frequently arising from the choroid, followed by the ciliary body and iris. Its diagnosis and management require precise characterization of tumor morphology,…

The Role of Spectacle Lenses in the Control and Management of Myopia Progression: A Narrative Review Open

Livio Vitiello, Filippo Lixi, Valerio Calabresi, Mario Troisi, Ilaria De Pascale , et al. · 2025

The number of people affected by myopia worldwide is estimated to reach two billion and to further grow. Therefore, numerous treatment approaches (pharmacological, behavioral, environmental, and optical) have been put forth to slow the pro…

Evaluation of AI Tools Versus the PRISMA Method for Literature Search, Data Extraction, and Study Composition in Glaucoma Systematic Reviews: Content Analysis Open

Laura Antonia Meliante, Giulia Coco, Alessandro Rabiolo, Stefano De Cillà, Gianluca Manni · 2025

Background Artificial intelligence (AI) is becoming increasingly popular in the scientific field, as it allows for the analysis of extensive datasets, summarizes results, and assists in writing academic papers. Objective This study investi…

Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery: A Prospective Double-Masked Randomized Controlled Clinical Trial Open

Mihaela-Madalina Timofte-Zorila, Filippo Lixi, Nicoleta Vlas, Mario Troisi, Gamze Özkan , et al. · 2025

NCT07067294, retrospectively registered on 05.07.2025.

Light discomfort thresholds in patients with senile cataract versus pseudophakic subjects Open

Filippo Lixi, Claudia Corda, Giulia Coco, Giovanna Carnovale-Scalzo, Alessandra Mancini , et al. · 2025

Purpose To compare light discomfort thresholds in patients with senile cataract versus pseudophakic subjects. Methods In this cross-sectional, multicenter, controlled study light discomfort thresholds were measured in both eyes of patients…

Light discomfort thresholds under different lighting conditions in healthy subjects and dry eye patients Open

Filippo Lixi, Giulia Coco, Claudia Corda, Edoardo Villani, Alessandra Curci , et al. · 2025

Intense Pulsed Light Combined with Low Level Blue and Red Light Therapy for Demodex-Associated Blepharitis Open

Sarah Farrant, Giuseppe Giannaccare, Chris Hong Long Lim, Giulia Coco · 2025

Combined light therapy with IPL and LLLT employing blue and red lights is an effective treatment strategy for patients with recalcitrant Demodex-associated blepharitis to reduce mites count and improve main ocular surface parameters…

AI deepfake: GPT-4o can produce near-authentic fundus images Open

Andrea Taloni, Maurizio Taloni, Giulia Coco, Danson Vasanthan Muttuvelu, Massimo Busin , et al. · 2025

Large language models provide discordant information compared to ophthalmology guidelines Open

Andrea Taloni, Antonia Carmen Sangregorio, Giuseppe Alessio, Maria Angela Romeo, Giulia Coco , et al. · 2025

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems Open

Giulia Coco, Valerio F. Annese, Valerio Galli, Ilaria Penna, Debora Russo , et al. · 2025

Edible electronics made of materials that can be safely ingested is researched for applications in food monitoring, drug delivery, and gastrointestinal tract screening, addressing sustainability and e‐waste concerns. Edible electronics can…

Enhancing Visual Quality: The Impact of Alcohol-Assisted Delamination on Corneal Aberrations in Patients with Central Epithelial Basement Membrane Dystrophy Open

M Messina, Giuseppe Giannaccare, Carlo Cagini, Paolo Fogagnolo, Maria Poddi , et al. · 2025

Background/Objectives: Epithelial basement membrane dystrophy (EBMD) is a common corneal dystrophy characterized by recurrent corneal erosions and visual impairments due to surface irregularities and opacities. This study aims to evaluate …

Repeatability of Pentacam HR in Keratoconus According to Two Different Scan Protocols: 25-3D Scan and 50-Cornea Fine Open

Davide Romano, Giulia Coco, Alfredo Borgia, Stefano Calza, Stephen B. Kaye , et al. · 2025

Background: This study aims to evaluate the repeatability of the Pentacam HR, comparing two different measurement modes (50-cornea fine and 25-3D scan) in patients affected by keratoconus. Methods: Multicenter retrospective study, conducte…

Efficacy of Perfluorohexyloctane for the Treatment of Patients With Dry Eye Disease: A Meta-Analysis Open

Andrea Taloni, Giulia Coco, Marco Pellegrini, Vincenzo Scorcia, Giuseppe Giannaccare · 2024

Introduction: To systematically review the evidence from randomized controlled trials that evaluate the efficacy and safety of perfluorohexyloctane in the treatment of dry eye disease. Methods: Literature search was conducted on PubMed and…

Digital Applications for Videoterminal-Associated Dry Eye Disease Open

Maria Angela Romeo, Giulia Coco, Andrea Taloni, Giovanna Carnovale-Scalzo, Vincenzo Scorcia , et al. · 2024

Dry eye disease (DED) has become increasingly prevalent in the digital era, largely due to prolonged screen exposure. The excessive use of digital devices contributes to inappropriate blink frequency and dynamics, leading to ocular surface…

Asymmetric Glaucoma and Corresponding Hearing Impairment Open

Laura Antonia Meliante, Giulia Coco, Beatrice Francavilla, Massimo Bianchi, Gianluca Velletrani , et al. · 2024

Background/Objectives: This study aims to explore the potential relationship between unilateral or asymmetric glaucoma and ipsilateral hearing impairment. Methods: In this retrospective study, visual and hearing functions were assessed in …

Safety, Tolerability, and Short-Term Efficacy of Low-Level Light Therapy for Dry Age-Related Macular Degeneration Open

Enrico Borrelli, Giulia Coco, Marco Pellegrini, Marco Mura, Nicolò Ciarmatori , et al. · 2024

Exploring the relationship between accommodation and intraocular pressure: a systematic literature review and meta-analysis Open

G. Ambrosini, Silvia Poletti, Gloria Roberti, Carmela Carnevale, Gianluca Manni , et al. · 2024

Recent Advances in Nanotechnology for the Treatment of Dry Eye Disease Open

Giulia Coco, Giacinta Buffon, Andrea Taloni, Giuseppe Giannaccare · 2024

Dry eye disease (DED) incidence is continuously growing, positioning it to become an emergent health issue over the next few years. Several topical treatments are commonly used to treat DED; however, reports indicate that only a minor prop…

Endothelial Migration and Regeneration after Penetrating Trauma Injury in a Deep Anterior Lamellar Keratoplasty Graft: Case Presentation and Literature Overview Open

Luca Pagano, Alfredo Borgia, Fadi Alfaqawi, Aruni K. Makuloluwa, Giulia Coco , et al. · 2024

Background: Traumatic injuries in eyes previously treated with Deep Anterior Lamellar Keratoplasty (DALK) can lead to ruptures in the Descemet Membrane (DM) and damage to the corneal endothelium, a crucial layer for maintaining corneal cla…

Glaucoma, Pseudoexfoliation and Hearing Loss: A Systematic Literature Review Open

Laura Antonia Meliante, Giulia Piccotti, Lucia Tanga, Sara Giammaria, Gianluca Manni , et al. · 2024

Purpose: To investigate the relationship between glaucoma, pseudoexfoliation and hearing loss (HL). Methods: A systematic literature search following PRISMA guidelines was conducted using the PubMed, Embase, Scopus and Cochrane databases f…

Suppression of Neovascularization by Topical and Subconjunctival Bevacizumab After High-Risk Corneal Transplantation Open

Thomas H. Dohlman, Rohan Bir Singh, Francisco Amparo, Tatiana Carreno-Galeano, Mohammad H. Dastjerdi , et al. · 2024

Ocular Surface Side Effects of Novel Anticancer Drugs Open

Livio Vitiello, Filippo Lixi, Giulia Coco, Giuseppe Giannaccare · 2024

Surgery, anticancer drugs (chemotherapy, hormonal medicines, and targeted treatments), and/or radiation are common treatment strategies for neoplastic diseases. Anticancer drugs eliminate malignant cells through the inhibition of specific …

GPT Wars: Creating and Detecting Fake Data Sets with Generative Artificial Intelligence Open

Andrea Taloni, Giulia Coco, Marco Pellegrini, Matthias Wjst, Vincenzo Scorcia , et al. · 2024

Safety and Efficacy of Dexamethasone Intravitreal Implant Given Either First-Line or Second-Line in Diabetic Macular Edema Open

Andrea Taloni, Giulia Coco, Davide Rastelli, Giacinta Buffon, Vincenzo Scorcia , et al. · 2023

Diabetic macular edema (DME) is a common sight-threatening complication of diabetic retinopathy (DR) and the leading cause of severe visual impairment among the working-age population. Several therapeutic options are available for the mana…

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination Open

Timothy P.H. Lin, Mrittika Sen, Vishali Gupta, Rupesh Agrawal, Paolo Lanzetta , et al. · 2023

Comparative performance of humans versus GPT-4.0 and GPT-3.5 in the self-assessment program of American Academy of Ophthalmology Open

Andrea Taloni, Massimiliano Borselli, Valentina Scarsi, Costanza Rossi, Giulia Coco , et al. · 2023

Combined Use of Therapeutic Hyper-CL Soft Contact Lens and Insulin Eye Drops for the Treatment of Recalcitrant Neurotrophic Keratopathy Open

Giuseppe Giannaccare, Giulia Coco, Costanza Rossi, Massimiliano Borselli, Andrea Lucisano , et al. · 2023

Purpose: The aim of this study was to report the successful clinical outcome of recalcitrant neurotrophic keratopathy (NK) treated with insulin eye drops associated with therapeutic Hyper-CL soft contact lens (CL) (EyeYon Medical, Ness Zio…

Comparative Performance of Humans Versus GPT-4.0 and GPT-3.5 in the Self-assessment Program of American Academy of Ophthalmology Open

Andrea Taloni, Massimiliano Borselli, Valentina Scarsi, Costanza Rossi, Giulia Coco , et al. · 2023

To compare the performance of humans, GPT-4.0 and GPT-3.5 in answering multiple-choice questions from the American Academy of Ophthalmology (AAO) Basic and Clinical Science Course (BCSC) self-assessment program, available at https://www.aa…

Artificial intelligence in cornea and ocular surface diseases Open

Luca Pagano, Matteo Posarelli, Giuseppe Giannaccare, Giulia Coco, Vincenzo Scorcia , et al. · 2023

In modern ophthalmology, the advent of artificial intelligence (AI) is gradually showing promising results. The application of complex algorithms to machine and deep learning has the potential to improve the diagnosis of various corneal an…

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