Giulia Grasso
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View article: Transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL) syndrome in children: case report and narrative review
Transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL) syndrome in children: case report and narrative review Open
Background The transient Headache and Neurological Deficit with cerebrospinal fluid Lymphocytosis (HaNDL) Syndrome is a rare form of primary headache, with few cases reported in children. Case presentation and review We report the case of …
View article: SUMO-2 activity is inhibited by non-covalent interactions with the Aβ peptide: an exploration of potential pathogenic mechanisms in Alzheimer's disease
SUMO-2 activity is inhibited by non-covalent interactions with the Aβ peptide: an exploration of potential pathogenic mechanisms in Alzheimer's disease Open
SUMOylation is a post-translational modification involving the addition of SUMO isoforms to target proteins and plays a role in various biological processes, including neurodegenerative diseases and ocular pathologies. This study investiga…
View article: Bis(4-((E)-3,5–Diacetoxystyryl)phenyl)nonanedioate
Bis(4-((E)-3,5–Diacetoxystyryl)phenyl)nonanedioate Open
Resveratrol is a natural stilbene known for its wide range of biological activities, including antioxidant, anti-inflammatory, and anti-aging effects. However, its application in cosmetics and dermatology is limited by poor stability and b…
View article: VEGF and the VEGF73-101 Fragment Prevent MPP+ Induced Mitochondrial Dysfunction in a Cell Model of Parkinson’s Disease
VEGF and the VEGF73-101 Fragment Prevent MPP+ Induced Mitochondrial Dysfunction in a Cell Model of Parkinson’s Disease Open
Vascular endothelial growth factor (VEGF) is best known for its role in angiogenesis, but emerging evidence suggests neurotrophic and neuroprotective functions most likely connected to energy homeostasis pathways. Using high-resolution res…
View article: Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life
Uterine fibroid embolization: An analysis of clinical outcomes and impact on patients’ quality of life Open
Background Uterine fibroids (UF) affect up to 70–80% of women by age 50 and are associated with heavy menstrual bleedings, pelvic discomfort, and reduced quality of life. Uterine artery embolization (UAE) is a minimally invasive procedure …
View article: AB0689 LIFESTYLE AND NUTRITIONAL STATUS IN ITALIAN PATIENTS WITH ISOLATED SJӦGREN'S SYNDROME
AB0689 LIFESTYLE AND NUTRITIONAL STATUS IN ITALIAN PATIENTS WITH ISOLATED SJӦGREN'S SYNDROME Open
View article: Cardiovascular Risk Factors and Family History of Major Thrombotic Events in Children with Migraine: A 12-Year Retrospective Single-Centre Study
Cardiovascular Risk Factors and Family History of Major Thrombotic Events in Children with Migraine: A 12-Year Retrospective Single-Centre Study Open
Background: Migraine is one of the most frequent primary headaches in childhood. The role of thrombotic predisposition in its pathogenesis is debated. Our aim was to analyse the cardiovascular risk factors and family history of major throm…
View article: Idiopathic Non-Dental Facial Pain Syndromes in Italian Children: A Clinical Case Series
Idiopathic Non-Dental Facial Pain Syndromes in Italian Children: A Clinical Case Series Open
Background. The orofacial pain syndromes (OFPs) are a heterogeneous group of syndromes characterized by painful attacks involving the orofacial structures. They may be summarily subdivided into two great categories: (1) orofacial pain main…
View article: The Cross-Talk between Microbiome and Metabolome in Rheumatoid Arthritis
The Cross-Talk between Microbiome and Metabolome in Rheumatoid Arthritis Open
Modern “omics” sciences, including metabolomics and microbiomics, are currently being applied to inflammatory autoimmune diseases, such as rheumatoid arthritis (RA), to investigate the interplay between microbiota, metabolic function, and …
View article: Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation
Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation Open
The microbial community acts as an active player in maintaining homeostasis and immune functions through a continuous and changeable cross-talk with the host immune system. Emerging evidence suggests that altered microbial composition, kno…
View article: Effect of The Gluten-Free Diet on Quality of Life, Gastrointestinal Symptoms and Immune System in Patients with Fibromyalgia and Non-Celiac Wheat Sensitivity. Fibromyalgia and Non-Celiac Wheat Sensitivity
Effect of The Gluten-Free Diet on Quality of Life, Gastrointestinal Symptoms and Immune System in Patients with Fibromyalgia and Non-Celiac Wheat Sensitivity. Fibromyalgia and Non-Celiac Wheat Sensitivity Open
Fibromyalgia (FM) is a clinical syndrome characterized by chronic pain. FM patients complain hyperalgesia and allodynia and they are frequently affected by Non Celiac Wheat Sensitivity (NCWS), a condition where gastrointestinal and extrain…
View article: A Multifunctional Nanoplatform Made of Gold Nanoparticles and Peptides Mimicking the Vascular Endothelial Growth Factor
A Multifunctional Nanoplatform Made of Gold Nanoparticles and Peptides Mimicking the Vascular Endothelial Growth Factor Open
In this work, nanobiohybrids of plasmonic gold nanoparticles (AuNP, anti-angiogenic) and a peptide mimicking the vascular endothelial growth factor (VEGF, pro-angiogenic) were assembled and scrutinized in terms of physicochemical character…
View article: Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview Open
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced by macrophages and dendritic cells, in response to ex…
View article: The Role of Copper (II) on Kininogen Binding to Tropomyosin in the Presence of a Histidine–Proline-Rich Peptide
The Role of Copper (II) on Kininogen Binding to Tropomyosin in the Presence of a Histidine–Proline-Rich Peptide Open
The antiangiogenic activity of the H/P domain of histidine–proline-rich glycoprotein is mediated by its binding with tropomyosin, a protein exposed on endothelial cell-surface during the angiogenic switch, in presence of zinc ions. Althoug…
View article: Primary Sjogren Syndrome: Focus on Innate Immune Cells and Inflammation
Primary Sjogren Syndrome: Focus on Innate Immune Cells and Inflammation Open
Primary Sjogren Syndrome (pSS) is a complex, multifactorial rheumatic disease that mainly targets salivary and lacrimal glands, inducing epithelitis. The cause behind the autoimmunity outbreak in pSS is still elusive; however, it seems rel…
View article: The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells
The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells Open
Copper plays an important role as a regulator in many pathologies involving the angiogenesis process. In cancerogenesis, tumor progression, and angiogenic diseases, copper homeostasis is altered. Although many details in the pathways invol…
View article: Hyaluronic acid and platelet-rich plasma, a new therapeutic alternative for scleroderma patients: a prospective open-label study
Hyaluronic acid and platelet-rich plasma, a new therapeutic alternative for scleroderma patients: a prospective open-label study Open
View article: P069. Osmophobia in children with headache
P069. Osmophobia in children with headache Open