Giulia Mazzini
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View article: Diagnostic Performance of the New Free Light Chain Ratio in Systemic Amyloidosis
Diagnostic Performance of the New Free Light Chain Ratio in Systemic Amyloidosis Open
The new FLCR demonstrates equivalent diagnostic sensitivity in AL amyloidosis and can be integrated into complete response criteria. In patients with suspected ATTRwt amyloidosis, it significantly reduces the proportion of FLCR-only abnorm…
View article: Bone Marrow-Free Sequencing of M Protein Genes: A Liquid Biopsy Approach in Monoclonal Gammopathies
Bone Marrow-Free Sequencing of M Protein Genes: A Liquid Biopsy Approach in Monoclonal Gammopathies Open
Introduction In patients with monoclonal gammopathies, M proteins are patient-unique, can cause potentially fatal organ damage and can be used to track the B cell/plasma cell tumor after therapy. The presence of circulating tumor cells and…
View article: Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis
Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis Open
Systemic light chain (LC) amyloidosis (AL) is a disease where organs are damaged by an overload of a misfolded patient-specific antibody-derived LC, secreted by an abnormal B cell clone. The high LC concentration in the blood leads to amyl…
View article: The processing intermediate of human amylin, pro-amylin(1–48), has in vivo and in vitro bioactivity
The processing intermediate of human amylin, pro-amylin(1–48), has in vivo and in vitro bioactivity Open
Amylin is released by pancreatic beta-cells in response to a meal and its major soluble mature form (37 amino acid-peptide) produces its biological effects by activating amylin receptors. Amylin is derived from larger propeptides that are …
View article: Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation
Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation Open
Broggini L, Barzago MM, Speranzini V, Schulte T, Sonzini F, Giono M, Romeo M, Milani P, Caminito S, Mazzini G, Rognoni P, Merlini G, Pappone C, Anastasia L, Nuvolone M, Palladini G, Diomede L, Ricagno S. Nanobodies counteract the toxicity …
View article: Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation
Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation Open
Broggini L, Barzago MM, Speranzini V, Schulte T, Sonzini F, Giono M, Romeo M, Milani P, Caminito S, Mazzini G, Rognoni P, Merlini G, Pappone C, Anastasia L, Nuvolone M, Palladini G, Diomede L, Ricagno S. Nanobodies counteract the toxicity …
View article: Helical superstructures between amyloid and collagen VI in heart-derived fibrils from a patient with Light Chain Amyloidosis.
Helical superstructures between amyloid and collagen VI in heart-derived fibrils from a patient with Light Chain Amyloidosis. Open
Systemic light chain (LC) amyloidosis (AL) is a disease where organs are damaged by an overload of a misfolded patient-specific antibody-derived LC, secreted by an abnormal B cell clone. The high LC concentration in the blood leads to amyl…
View article: P823: BONE MARROW-FREE SEQUENCING OF M PROTEIN GENES IN MONOCLONAL GAMMOPATHIES
P823: BONE MARROW-FREE SEQUENCING OF M PROTEIN GENES IN MONOCLONAL GAMMOPATHIES Open
In patients with monoclonal gammopathies, M proteins are patient-unique, can cause potentially fatal organ damage and can be used to track the B cell/plasma cell tumor after therapy. The presence of circulating tumor cells and the possibil…
View article: The Cryo-EM structure of renal amyloid fibril suggests structurally homogeneous multiorgan aggregation in AL amyloidosis
The Cryo-EM structure of renal amyloid fibril suggests structurally homogeneous multiorgan aggregation in AL amyloidosis Open
Immunoglobulin light chain amyloidosis (AL) is caused by the aberrant production of amyloidogenic light chains (LC) that accumulate as amyloid deposits in vital organs. Distinct LC sequences in each patient yield distinct amyloid structure…
View article: AA-amyloidosis in cats (Felis catus) housed in shelters
AA-amyloidosis in cats (Felis catus) housed in shelters Open
Systemic AA-amyloidosis is a protein-misfolding disease characterized by fibril deposition of serum amyloid-A protein (SAA) in several organs in humans and many animal species. Fibril deposits originate from abnormally high serum levels of…
View article: Node of Ranvier remodeling in chronic psychosocial stress and anxiety
Node of Ranvier remodeling in chronic psychosocial stress and anxiety Open
Differential expression of myelin-related genes and changes in myelin thickness have been demonstrated in mice after chronic psychosocial stress, a risk factor for anxiety disorders. To determine whether and how stress affects structural r…
View article: 593 PRESENTATION AND OUTCOME OF PATIENTS WITH COEXISTING CARDIAC AL AND ATTR AMYLOIDOSIS
593 PRESENTATION AND OUTCOME OF PATIENTS WITH COEXISTING CARDIAC AL AND ATTR AMYLOIDOSIS Open
Background Incidence of ATTRwt amyloidosis increased in the last years, especially thanks to the possibility of a non-bioptic diagnosis. However, if a monoclonal component (MC) is detected, amyloid typing is mandatory to rule out AL amyloi…
View article: Mind the gap: Nodes of Ranvier are remodeled by chronic psychosocial stress and neuronal activity
Mind the gap: Nodes of Ranvier are remodeled by chronic psychosocial stress and neuronal activity Open
Differential expression of myelin-related genes and changes in myelin thickness have been demonstrated in mice after chronic psychosocial stress, a risk factor for anxiety disorders. To determine whether and how stress affects structural r…
View article: Cryo-EM structure of<i>ex vivo</i>fibrils associated with extreme AA amyloidosis prevalence in a cat shelter
Cryo-EM structure of<i>ex vivo</i>fibrils associated with extreme AA amyloidosis prevalence in a cat shelter Open
AA amyloidosis is a systemic disease characterized by deposition of misfolded serum amyloid A protein (SAA) into cross-β amyloid in multiple organs in humans and animals. AA amyloidosis occurs at high SAA serum levels during chronic inflam…
View article: AA-amyloidosis in cats (<i>Felis catus</i>) housed in shelters
AA-amyloidosis in cats (<i>Felis catus</i>) housed in shelters Open
Systemic AA-amyloidosis is a protein-misfolding disease that is characterized by fibril deposition of serum amyloid-A protein (SAA) in several organs in humans and many animal species. Fibril deposits originate from abnormally high serum l…
View article: Mind the gap: Nodes of Ranvier are remodeled by chronic psychosocial stress and neuronal activity
Mind the gap: Nodes of Ranvier are remodeled by chronic psychosocial stress and neuronal activity Open
Differential expression of myelin-related genes and changes in myelin thickness have been demonstrated in mice after chronic psychosocial stress, a risk factor for anxiety disorders. To determine whether and how stress affects structural r…
View article: Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation
Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation Open
Light‐chain (AL) amyloidosis is characterized by deposition of immunoglobulin light chains (LC) as fibrils in target organs. Alongside the full‐length protein, abundant LC fragments are always present in AL deposits. Herein, by combining g…
View article: Dissecting the Molecular Features of Systemic Light Chain (AL) Amyloidosis: Contributions from Proteomics
Dissecting the Molecular Features of Systemic Light Chain (AL) Amyloidosis: Contributions from Proteomics Open
Amyloidoses are characterized by aggregation of proteins into highly ordered amyloid fibrils, which deposit in the extracellular space of tissues, leading to organ dysfunction. In AL (amyloid light chain) amyloidosis, the most common form …
View article: Heparanase as an Additional Tool for Detecting Structural Peculiarities of Heparin Oligosaccharides
Heparanase as an Additional Tool for Detecting Structural Peculiarities of Heparin Oligosaccharides Open
Due to the biological properties of heparin and low-molecular-weight heparin (LMWH), continuous advances in elucidation of their microheterogeneous structure and discovery of novel structural peculiarities are crucial. Effective strategies…
View article: Combining NMR Spectroscopy and Chemometrics to Monitor Structural Features of Crude Hep-arin
Combining NMR Spectroscopy and Chemometrics to Monitor Structural Features of Crude Hep-arin Open
Because of the complexity and global nature of the heparin supply chain, the control of heparin quality during manufacturing steps is essential to ensure the safety of the final active pharmaceutical ingredient (API). For this reason, ther…