Giulia Menculini
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View article: Exploring emerging psychopathological characteristics and challenges of novel depression subtypes: insights from the literature
Exploring emerging psychopathological characteristics and challenges of novel depression subtypes: insights from the literature Open
Background Depression is a widespread global health issue, significantly impacting all areas of life and is a leading cause of disability. Societal changes, including technological and cultural shifts, and the emergence of new psychoactive…
View article: Beyond “Fire” and “Ashes”: The Influence of Trait Characteristics on the Response to Mood Stabilizers in Bipolar Disorders
Beyond “Fire” and “Ashes”: The Influence of Trait Characteristics on the Response to Mood Stabilizers in Bipolar Disorders Open
Background: The present study aimed to investigate the clinical correlates of treatment response to mood stabilizers in patients with bipolar disorder (BD), with a specific focus on trait-related characteristics such as impulsivity and aff…
View article: Emerging strategies and clinical recommendations for the management of novel depression subtypes
Emerging strategies and clinical recommendations for the management of novel depression subtypes Open
In the novel depression subtypes discussed, individualized treatment approaches tailored to the individual's specific circumstances are necessary. While selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reupta…
View article: Sex differences in psychosocial functioning and neurocognition in bipolar disorder: a systematic review and meta-analysis
Sex differences in psychosocial functioning and neurocognition in bipolar disorder: a systematic review and meta-analysis Open
Introduction Impairment in both psychosocial functioning and neurocognition (NC) performance is present in bipolar disorder (BD) yet the role of sex differences in these deficits remains unclear. The present systematic review and meta-anal…
View article: Sex matters: Differences in prodromes, clinical and neuropsychological features in individuals with a first episode mania or psychosis
Sex matters: Differences in prodromes, clinical and neuropsychological features in individuals with a first episode mania or psychosis Open
The main finding is the presence of significant sex effect and group by sex interaction on specific neurocognitive cognition and emotional intelligence measures. Tailored sex-based early treatment strategies might be implemented.
View article: Insights into the Effect of Light Pollution on Mental Health: Focus on Affective Disorders—A Narrative Review
Insights into the Effect of Light Pollution on Mental Health: Focus on Affective Disorders—A Narrative Review Open
The presence of artificial light at night has emerged as an anthropogenic stressor in recent years. Various sources of light pollution have been shown to affect circadian physiology with serious consequences for metabolic pathways, possibl…
View article: Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode
Sex differences in prolactin levels and clinical outcomes in patients with a first psychotic episode Open
Prolactin plays a role in the functionality and clinical symptomatology of FEP patients. Our results suggest that pharmacological counselling in patients with hyperprolactinemia at baseline and negative symptomatology might improve their f…
View article: Major challenges in youth psychopathology: treatment-resistant depression. A narrative review
Major challenges in youth psychopathology: treatment-resistant depression. A narrative review Open
Major depressive disorder (MDD) represents a major health issue in adolescents and young adults, leading to high levels of disability and profoundly impacting overall functioning. The clinical presentation of MDD in this vulnerable age gro…
View article: The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis
The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis Open
Background Polygenic risk scores for educational attainment (PRS EA ), cognitive reserve (CR), and clinical symptoms are associated with functioning in first-episode psychosis (FEP). Nevertheless, the mechanisms underlying their complex in…
View article: The interplay between mentalization, personality traits and burnout in psychiatry training: Results from a large multicenter controlled study
The interplay between mentalization, personality traits and burnout in psychiatry training: Results from a large multicenter controlled study Open
Background A better characterization of educational processes during psychiatry training is needed, both to foster personal resilience and occupational proficiency. Methods An adequate coverage of medical residents at the national level wa…
View article: A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with Schizophrenia
A Systematic Review on the Effectiveness of Antipsychotic Drugs on the Quality of Life of Patients with Schizophrenia Open
Pharmacological antipsychotic drug interventions represent the cornerstone of the management of patients with schizophrenia and other psychotic spectrum disorders. The choice of the “best” treatment should be made on the basis of several c…
View article: Sleep Disturbances in Panic Disorder with Comorbid Complex PTSD: A Possible Relationship and Different Psychopathology?
Sleep Disturbances in Panic Disorder with Comorbid Complex PTSD: A Possible Relationship and Different Psychopathology? Open
Background: Several studies have shown the possible link between trauma and sleep disturbances, particularly in anxiety disorders. This issue could be because sympathetic hyperarousal is central to both disorders, probably caused by a dysr…
View article: Eating disorders and emotional dysregulation are associated with insufficient weight loss after bariatric surgery: a 1-year observational follow-up study
Eating disorders and emotional dysregulation are associated with insufficient weight loss after bariatric surgery: a 1-year observational follow-up study Open
Purpose subjects with obesity, especially those seeking bariatric surgery, exhibit high rates of mental disorders and marked psychopathological traits. The primary objective of this prospective, non-interventional study was to investigate …
View article: DIMENSIONAL DIAGNOSIS IN SCHIZOPHRENIA SPECTRUM DISORDERS: A CASE REPORT
DIMENSIONAL DIAGNOSIS IN SCHIZOPHRENIA SPECTRUM DISORDERS: A CASE REPORT Open
Introduction The use of diagnostic categories, although useful, fails in capturing the psychopathological complexity of the individual case. As for schizophrenia spectrum disorders, positive symptoms are not always included in the presenta…
View article: Suicidality among adolescents and young adults in a Psychiatry Inpatient Unit: a two-year retrospective study in Umbria, central Italy
Suicidality among adolescents and young adults in a Psychiatry Inpatient Unit: a two-year retrospective study in Umbria, central Italy Open
Introduction Suicide is the fourth leading cause of death among adolescents and young adults (AYA) (Czyz EK, King CA. J Clin Child Adolesc Psychol. 2015;44(1):181-19), and psychiatric disorders are a major contributing factor (WHO Global H…
View article: Circadian rhythm disturbances in mood disorders: characterisation and clinical impact
Circadian rhythm disturbances in mood disorders: characterisation and clinical impact Open
Introduction Circadian rhythms, defined as endogenous oscillations that regulate metabolism, physiology and behaviour, may be frequently disrupted in mood disorders, influencing their clinical presentation and course (Srinivasan V. et al. …
View article: Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance
Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance Open
Patients with a generalized anxiety disorder (GAD) often report preeminent sleep disturbances. Recently, calcium homeostasis gained interest because of its role in the regulation of sleep–wake rhythms and anxiety symptoms. This cross-secti…
View article: Access to a psychiatric emergency setting during the COVID-19 pandemic: focus on youth populations
Access to a psychiatric emergency setting during the COVID-19 pandemic: focus on youth populations Open
Introduction The COVID-19 outbreak and the related containment measures led to the emergence of psychological distress in youth populations, possibly due to concern for their families, social isolation, increased time spent on the Internet…
View article: Forcibly displaced persons and mental health: A survey of the experiences of Europe-wide psychiatry trainees during their training
Forcibly displaced persons and mental health: A survey of the experiences of Europe-wide psychiatry trainees during their training Open
Many European countries have seen increasing refugee populations and asylum applications over the past decade. Forcibly displaced persons (FDPs) are known to be at higher risk of developing mental disorders and are in need of specific care…