Giulia Miracca
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View article: The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation
The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation Open
Activating the adra2a receptors of the brain’s norepinephrine (NE) system produces NREM-like sleep and hypothermia. Dexmedetomidine (DEX), a selective α2 receptor ( adra2a ) agonist, is an important drug used in intensive care for arousabl…
View article: Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion Disease
Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion Disease Open
Neurodegenerative conditions can induce the region-specific emergence of cell states relevant to their pathogenesis. To identify such phenomena, we generated a spatiotemporal transcriptomic atlas of mice infected with the RML prion strain.…
View article: Nociceptor spontaneous activity is responsible for fragmenting non–rapid eye movement sleep in mouse models of neuropathic pain
Nociceptor spontaneous activity is responsible for fragmenting non–rapid eye movement sleep in mouse models of neuropathic pain Open
Spontaneous pain, a major complaint of patients with neuropathic pain, has eluded study because there is no reliable marker in either preclinical models or clinical studies. Here, we performed a comprehensive electroencephalogram/electromy…
View article: Somatostatin neurons in prefrontal cortex initiate sleep preparatory behavior and sleep via the preoptic and lateral hypothalamus.
Somatostatin neurons in prefrontal cortex initiate sleep preparatory behavior and sleep via the preoptic and lateral hypothalamus. Open
Script written by Nicholas P. Franks for GCaMP power analysis
View article: NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep
NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep Open
The lateral preoptic (LPO) hypothalamus is a center for NREM and REM sleep induction and NREM sleep homeostasis. Although LPO is needed for NREM sleep, we found that calcium signals were, surprisingly, highest in REM sleep. Furthermore, an…
View article: Hypothalamic NMDA receptors stabilize NREM sleep and are essential for REM sleep
Hypothalamic NMDA receptors stabilize NREM sleep and are essential for REM sleep Open
SUMMARY The preoptic hypothalamus regulates both NREM and REM sleep. We found that calcium levels in mouse lateral preoptic (LPO) neurons were highest during REM. Deleting the core GluN1 subunit of NMDA receptors from LPO neurons abolished…
View article: Sleep deprivation triggers somatostatin neurons in prefrontal cortex to initiate nesting and sleep via the preoptic and lateral hypothalamus
Sleep deprivation triggers somatostatin neurons in prefrontal cortex to initiate nesting and sleep via the preoptic and lateral hypothalamus Open
Animals undertake specific behaviors before sleep. Little is known about whether these innate behaviors, such as nest building, are actually an intrinsic part of the sleep-inducing circuitry. We found, using activity-tagging genetics, that…
View article: Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation
Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation Open
Our urge to sleep increases with time spent awake, until sleep becomes inescapable. The sleep following sleep deprivation is longer and deeper, with an increased power of delta (0.5-4 Hz) oscillations, a phenomenon termed sleep homeostasis…
View article: Galanin neurons in the hypothalamus link sleep homeostasis, body temperature and actions of the α2 adrenergic agonist dexmedetomidine
Galanin neurons in the hypothalamus link sleep homeostasis, body temperature and actions of the α2 adrenergic agonist dexmedetomidine Open
Sleep deprivation induces a characteristic rebound in NREM sleep accompanied by an immediate increase in the power of delta (0.5 - 4 Hz) oscillations, proportional to the prior time awake. To test the idea that galanin neurons in the mouse…
View article: Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation
Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation Open
The lateral habenula has been widely studied for its contribution in generating reward-related behaviors [1, 2]. We have found that this nucleus plays an unexpected role in the sedative actions of the general anesthetic propofol. The later…