Giulia Murtas
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View article: Correlation between active regions’ spectra at high radio frequencies and solar flare occurrences
Correlation between active regions’ spectra at high radio frequencies and solar flare occurrences Open
High radio frequencies observations with the Italian network of large single-dish radio telescopes resulted in ∼450 solar images between 2018 and 2023 in K-band frequency range (18-26 GHz). Solar radio mapping at these frequencies allows t…
View article: Biochemical and cellular studies of three human 3‐phosphoglycerate dehydrogenase variants responsible for pathological reduced L‐serine levels
Biochemical and cellular studies of three human 3‐phosphoglycerate dehydrogenase variants responsible for pathological reduced L‐serine levels Open
In the brain, the non‐essential amino acid L‐serine is produced through the phosphorylated pathway (PP) starting from the glycolytic intermediate 3‐phosphoglycerate: among the different roles played by this amino acid, it can be converted …
View article: Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization
Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization Open
In humans, the phosphorylated pathway (PP) converts the glycolytic intermediate D-3-phosphoglycerate (3-PG) into L-serine through the enzymes 3-phosphoglycerate dehydrogenase, phosphoserine aminotransferase (PSAT) and phosphoserine phospha…
View article: Serine metabolism during differentiation of human <scp>iPSC</scp>‐derived astrocytes
Serine metabolism during differentiation of human <span>iPSC</span>‐derived astrocytes Open
Astrocytes are essential players in development and functions, being particularly relevant as regulators of brain energy metabolism, ionic homeostasis and synaptic transmission. They are also the major source of l ‐serine in the brain, whi…
View article: The human phosphorylated pathway: a multienzyme metabolic assembly for <scp>l</scp>‐serine biosynthesis
The human phosphorylated pathway: a multienzyme metabolic assembly for <span>l</span>‐serine biosynthesis Open
De novo l ‐serine biosynthesis in the mammalian astrocytes proceeds via a linear, three‐step pathway (the phosphorylated pathway) catalysed by 3‐phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserin…
View article: L‐serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase
L‐serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase Open
Organisms from all kingdoms of life synthesize L‐serine (L‐Ser) from 3‐phosphoglycerate through the phosphorylated pathway, a three‐step diversion of glycolysis. Phosphoserine aminotransferase (PSAT) catalyzes the intermediate step, the py…
View article: D-Amino Acids and Cancer: Friends or Foes?
D-Amino Acids and Cancer: Friends or Foes? Open
α-amino acids exist in two configurations, named D-(dextro) and L-(levo) enantiomers. L-amino acids are used in protein synthesis and play a central role in cell metabolism. The effects of the L-amino acid composition of foods and the diet…
View article: Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus
Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus Open
Healthy aging is an ambitious aspiration for humans, but neurodegenerative disorders, such as Alzheimer's disease (AD), strongly affect quality of life. Using an integrated omics approach, we investigate alterations in the molecular compos…
View article: Biochemical Properties and Physiological Functions of pLG72: Twenty Years of Investigations
Biochemical Properties and Physiological Functions of pLG72: Twenty Years of Investigations Open
In 2002, the novel human gene G72 was associated with schizophrenia susceptibility. This gene encodes a small protein of 153 amino acids, named pLG72, which represents a rare case of primate-specific protein. In particular, the rs2391191 s…
View article: Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism
Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism Open
In recent years, the D-enantiomers of amino acids have been recognized as natural molecules present in all kingdoms, playing a variety of biological roles. In humans, d -serine and d -aspartate attracted attention for their presence in the…
View article: Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase
Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase Open
The human enzyme D-3-phosphoglycerate dehydrogenase (hPHGDH) catalyzes the reversible dehydrogenation of 3-phosphoglycerate (3PG) into 3-phosphohydroxypyruvate (PHP) using the NAD+/NADH redox cofactor, the first step in the phosphorylated …
View article: Antimicrobial d-amino acid oxidase-derived peptides specify gut microbiota
Antimicrobial d-amino acid oxidase-derived peptides specify gut microbiota Open
The flavoenzyme d -amino acid oxidase (DAAO) is deputed to the degradation of d -enantiomers of amino acids. DAAO plays various relevant physiological roles in different organisms and tissues. Thus, it has been recently suggested that the …
View article: Substitution of Arginine 120 in Human D-Amino Acid Oxidase Favors FAD-Binding and Nuclear Mistargeting
Substitution of Arginine 120 in Human D-Amino Acid Oxidase Favors FAD-Binding and Nuclear Mistargeting Open
The peroxisomal enzyme human D-amino acid oxidase (hDAAO) is attracting attention owing to its role in degrading D-serine, the main co-agonist of N-methyl D-aspartate receptors in brain, and its involvement in brain functions and diseases.…
View article: Human D-Amino Acid Oxidase: Structure, Function, and Regulation
Human D-Amino Acid Oxidase: Structure, Function, and Regulation Open
D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only exception being the acidic ones. This flavoenzyme plays different …
View article: Biochemical Properties of Human D-amino Acid Oxidase Variants and Their Potential Significance in Pathologies
Biochemical Properties of Human D-amino Acid Oxidase Variants and Their Potential Significance in Pathologies Open
The stereoselective flavoenzyme D-amino acid oxidase (DAAO) catalyzes the oxidative deamination of neutral and polar D-amino acids producing the corresponding α-keto acids, ammonia, and hydrogen peroxide. Despite its peculiar and atypical …
View article: Biochemical Properties of Human D-Amino Acid Oxidase
Biochemical Properties of Human D-Amino Acid Oxidase Open
D-amino acid oxidase catalyzes the oxidative deamination of D-amino acids. In the brain, the NMDA receptor coagonist D-serine has been proposed as its physiological substrate. In order to shed light on the mechanisms regulating D-serine co…