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View article: The <i>E. coli</i> CNF1 toxin induces fetal reprogramming of intestinal stem cells and a serrated colorectal cancer transcriptional signature in organoids
The <i>E. coli</i> CNF1 toxin induces fetal reprogramming of intestinal stem cells and a serrated colorectal cancer transcriptional signature in organoids Open
SUMMARY Mechanistic insights are essential to understand how gut microbiota pathobionts contribute to tumorigenesis, given the mounting evidence linking them to colorectal cancer. We report a higher prevalence of the Rho GTPases-targeting …
View article: Bone Health in Metabolic Syndrome—Is It a Neglected Aspect of Dysmetabolic-Related Diseases?
Bone Health in Metabolic Syndrome—Is It a Neglected Aspect of Dysmetabolic-Related Diseases? Open
Due to their widespread prevalence and the aging global population, metabolic syndrome (MetS) and osteoporosis represent significant public health challenges. Clinical interest in MetS is currently primarily focused on cardiovascular risks…
View article: Publisher Correction: Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid
Publisher Correction: Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid Open
View article: Hypothalamic–pituitary–adrenal axis in anorexia nervosa; an underestimated endocrine dysfunction among adolescents
Hypothalamic–pituitary–adrenal axis in anorexia nervosa; an underestimated endocrine dysfunction among adolescents Open
In patients affected by anorexia nervosa (AN) different endocrine abnormalities have been described, but, among them, hypothalamic–pituitary–adrenal (HPA) dysfunction, although associated to important side effects, is underestimated and ha…
View article: CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming
CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming Open
Colorectal cancer (CRC) progression is shaped by the tumor microenvironment, particularly tumor-associated macrophages (TAMs), which often adopt immunosuppressive functions. CD300e, a myeloid receptor involved in immune regulation, has an …
View article: Author Correction: Global proteomic identifies multiple cancer-related signaling pathways altered by a gut pathobiont associated with colorectal cancer
Author Correction: Global proteomic identifies multiple cancer-related signaling pathways altered by a gut pathobiont associated with colorectal cancer Open
View article: <i>Parvimonas micra</i> , an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes
<i>Parvimonas micra</i> , an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes Open
Recently, an intestinal dysbiotic microbiota with enrichment in oral cavity bacteria has been described in colorectal cancer (CRC) patients. Here, we characterize and investigate one of these oral pathobionts, the Gram-positive anaerobic c…
View article: Global proteomic identifies multiple cancer-related signaling pathways altered by a gut pathobiont associated with colorectal cancer
Global proteomic identifies multiple cancer-related signaling pathways altered by a gut pathobiont associated with colorectal cancer Open
View article: The oncogenic role of<i>Streptococcus gallolyticus subsp</i>.<i>gallolyticus</i>is linked to activation of multiple cancer-related signaling pathways
The oncogenic role of<i>Streptococcus gallolyticus subsp</i>.<i>gallolyticus</i>is linked to activation of multiple cancer-related signaling pathways Open
Streptococcus gallolyticus subsp. gallolyticus (SGG) , an opportunistic gram-positive pathogen responsible for septicemia and endocarditis in the elderly, is often associated with colon cancer (CRC). In this work, we investigated the oncog…
View article: <i>Parvimonas micra</i>, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human primary intestinal epithelial cells
<i>Parvimonas micra</i>, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human primary intestinal epithelial cells Open
Summary Recently, an intestinal dysbiotic microbiota with enrichment in oral cavity bacteria has been described in colorectal cancer (CRC) patients. Here we characterized and investigated one of these oral pathobionts, the Gram-positive an…
View article: PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms Open
View article: A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection Open
View article: Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe Open
Reactive oxygen species (ROS) play essential roles in intestinal homeostasis. ROS are natural by-products of cell metabolism. They are produced in response to infection or injury at the mucosal level as they are involved in antimicrobial r…
View article: A virus-encoded microRNA contributes to evade innate immune response during SARS-CoV-2 infection
A virus-encoded microRNA contributes to evade innate immune response during SARS-CoV-2 infection Open
SARS-CoV-2 infection results in impaired interferon response in severe COVID-19 patients. However, how SARS-CoV-2 interferes with host immune response is incompletely understood. Here, we sequenced small RNAs from SARS-CoV-2-infected human…
View article: Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism
Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism Open
View article: Innate immune receptor NOD2 mediates LGR5 <sup>+</sup> intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation
Innate immune receptor NOD2 mediates LGR5 <sup>+</sup> intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation Open
The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) + intestin…
View article: DNA Hypermethylation Downregulates Telomerase Reverse Transcriptase (TERT) during <i>H. pylori</i>-Induced Chronic Inflammation
DNA Hypermethylation Downregulates Telomerase Reverse Transcriptase (TERT) during <i>H. pylori</i>-Induced Chronic Inflammation Open
Helicobacter pylori infection causes chronic gastritis and is the major risk factor of gastric cancer. H. pylori induces a chronic inflammation-producing reactive oxygen species (ROS) which is a source of chromosome instabilities and contr…
View article: Intracellular offspring released from SFB filaments are flagellated
Intracellular offspring released from SFB filaments are flagellated Open
View article: Decrypting the communication between microbes and the intestinal mucosa—A brief review on Pathogénie Microbienne Moléculaire's latest research
Decrypting the communication between microbes and the intestinal mucosa—A brief review on Pathogénie Microbienne Moléculaire's latest research Open
Over the past 10 years, the "Pathogénie Microbienne Moléculaire" unit of Professor Philippe Sansonetti has studied the molecular cross talk between the intestinal microbiota and the gut epithelium, aiming to better understand how this mutu…
View article: The bacterial receptor NOD2 mediates LGR5+ intestinal stem cells protection against irradiation via mitophagy activation
The bacterial receptor NOD2 mediates LGR5+ intestinal stem cells protection against irradiation via mitophagy activation Open
View article: Mapping of <i>Shigella flexneri</i>’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs
Mapping of <i>Shigella flexneri</i>’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs Open
Shigella spp. are bacterial pathogens that invade the human colonic mucosa using a type III secretion apparatus (T3SA), a proteinaceous device activated upon contact with host cells. Active T3SAs translocate proteins that carve the intrace…
View article: Innate immune recognition of a bacterial MAMP leads to conditional activation of pro- or anti-inflammatory responses
Innate immune recognition of a bacterial MAMP leads to conditional activation of pro- or anti-inflammatory responses Open
Summary Microbe-associated molecular patterns (MAMPs) are recognized by pattern recognition receptors (PRRs) of the innate immune system. Flagellin, the primary component of bacterial flagella, is recognized by membrane TLR5 and cytoplasmi…
View article: <i>Shigella</i>promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport
<i>Shigella</i>promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport Open
Intracellular trafficking pathways in eukaryotic cells are essential to maintain organelle identity and structure, and to regulate cell communication with its environment. Shigella flexneri invades and subverts the human colonic epithelium…
View article: Stress‐induced host membrane remodeling protects from infection by non‐motile bacterial pathogens
Stress‐induced host membrane remodeling protects from infection by non‐motile bacterial pathogens Open
View article: Disentangling Host-Microbiota Regulation of Lipid Secretion by Enterocytes: Insights from Commensals <i>Lactobacillus paracasei</i> and <i>Escherichia coli</i>
Disentangling Host-Microbiota Regulation of Lipid Secretion by Enterocytes: Insights from Commensals <i>Lactobacillus paracasei</i> and <i>Escherichia coli</i> Open
The specific contribution of each bacterial species within a complex microbiota to the regulation of host lipid metabolism remains largely unknown. Using two model commensal microorganisms, L. paracasei and E. coli , we demonstrated that b…
View article: MUB40 Binds to Lactoferrin and Stands as a Specific Neutrophil Marker
MUB40 Binds to Lactoferrin and Stands as a Specific Neutrophil Marker Open
View article: Colorectal cancer specific conditions promote<i>Streptococcus gallolyticus</i>gut colonization
Colorectal cancer specific conditions promote<i>Streptococcus gallolyticus</i>gut colonization Open
Significance Growing evidence indicates a correlation between colorectal cancer and intestinal dysbiosis or colonization by single bacterial species such as Streptococcus gallolyticus subsp. gallolyticus (SGG), yet a causality link remains…
View article: Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation
Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation Open
Disruption of the sumoylation/desumoylation equilibrium is associated with several disease states such as cancer and infections, however the mechanisms regulating the global SUMO balance remain poorly defined. Here, we show that infection …
View article: Author response: Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation
Author response: Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation Open
View article: Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation Balance
Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation Balance Open
We identified a crypt-specific core microbiota (CSCM) dominated by strictly aerobic, nonfermentative bacteria in murine cecal and proximal colonic (PC) crypts and hypothesized that, among its possible functions, it may affect epithelial re…