Giulia Pinton
YOU?
Author Swipe
View article: EZH2 Inhibition in Mesothelioma Cells Increases the Release of Extracellular Vesicles That Skew Neutrophils Toward a Protumor Phenotype
EZH2 Inhibition in Mesothelioma Cells Increases the Release of Extracellular Vesicles That Skew Neutrophils Toward a Protumor Phenotype Open
We previously demonstrated that in BAP1-proficient pleural mesothelioma cells, CDKN2A is critical for mediating the response to selective EZH2 inhibition and highlighted a complex interplay between epigenetic regulation and the tumor immun…
View article: EZH2-Mediated H3K27 Trimethylation in the Liver of Mice Is an Early Epigenetic Event Induced by High-Fat Diet Exposure
EZH2-Mediated H3K27 Trimethylation in the Liver of Mice Is an Early Epigenetic Event Induced by High-Fat Diet Exposure Open
Background/Objectives: Methyltransferase EZH2-mediated H3K27me3 is involved in liver inflammation and fibrosis, but its role in hepatic metabolic derangements is not yet clearly defined. We investigated if a high-fat diet (HFD) induced ear…
View article: A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers
A New Vista of Aldehyde Dehydrogenase 1A3 (ALDH1A3): New Specific Inhibitors and Activity-Based Probes Targeting ALDH1A3 Dependent Pathways in Glioblastoma, Mesothelioma and Other Cancers Open
Aldehyde dehydrogenases of the subfamily 1A (ALDH1A) are enzymes necessary for the oxidation of all-trans or 9-cis retinal to retinoic acid (RA). Retinoic acid and its derivatives are important for normal development and maintenance of epi…
View article: Melanoma Cells Inhibit iNKT Cell Functions via PGE2 and IDO1
Melanoma Cells Inhibit iNKT Cell Functions via PGE2 and IDO1 Open
Invariant natural killer T (iNKT) cells are a distinct group of immune cells known for their immunoregulatory and cytotoxic activities, which are crucial in immune surveillance against tumors. They have been extensively investigated as a p…
View article: A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment
A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment Open
Aldehyde dehydrogenase 1A3 (ALDH1A3), one of the three members of the aldehyde dehydrogenase 1A subfamily, has been associated with increased progression and drug resistance in various types of solid tumours. Recently, it has been reported…
View article: Benefits and Challenges of Inhibiting EZH2 in Malignant Pleural Mesothelioma
Benefits and Challenges of Inhibiting EZH2 in Malignant Pleural Mesothelioma Open
Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer that is mainly associated with prior exposure to asbestos fibers. Despite being a rare cancer, its global rate is increasing and the prognosis remains extremely poor. Ov…
View article: Epigenetic Insights on PARP-1 Activity in Cancer Therapy
Epigenetic Insights on PARP-1 Activity in Cancer Therapy Open
The regulation of chromatin state and histone protein eviction have been proven essential during transcription and DNA repair. Poly(ADP-ribose) (PAR) polymerase 1 (PARP-1) and poly(ADP-ribosyl)ation (PARylation) are crucial mediators of th…
View article: Corrigendum: CDKN2A determines mesothelioma cell fate to EZH2 inhibition
Corrigendum: CDKN2A determines mesothelioma cell fate to EZH2 inhibition Open
[This corrects the article DOI: 10.3389/fonc.2021.678447.].
View article: The Strange Case: The Unsymmetric Cisplatin‐Based Pt(IV) Prodrug [Pt(CH<sub>3</sub>COO)Cl<sub>2</sub>(NH<sub>3</sub>)<sub>2</sub>(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier‐Mediated Cellular Uptake
The Strange Case: The Unsymmetric Cisplatin‐Based Pt(IV) Prodrug [Pt(CH<sub>3</sub>COO)Cl<sub>2</sub>(NH<sub>3</sub>)<sub>2</sub>(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier‐Mediated Cellular Uptake Open
The biological behavior of the axially unsymmetric antitumor prodrug ( OC ‐6‐44)‐acetatodiamminedichloridohydroxidoplatinum(IV), 2 , was deeply investigated and compared with that of analogous symmetric Pt(IV) complexes, namely, dihydroxid…
View article: Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines
Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines Open
Cisplatin is widely employed as a first-line chemotherapeutic agent for many solid tumors, including malignant pleural mesothelioma (MPM). However, its clinical use is limited by heavy side effects and acquired resistance, the latter being…
View article: CDKN2A Determines Mesothelioma Cell Fate to EZH2 Inhibition
CDKN2A Determines Mesothelioma Cell Fate to EZH2 Inhibition Open
Malignant pleural mesothelioma is an aggressive cancer, heterogeneous in its presentation and behaviour. Despite an increasing knowledge about molecular markers and their diagnostic and prognostic value, they are not used as much as they m…
View article: Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids
Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids Open
Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a long latency period and dismal prognosis. Recently, tazemetostat (EPZ-6438), an inhibitor of the histone methyltransferase EZH2, has entered clinical trials due to t…
View article: Expression and clinical implications of estrogen receptors in thoracic malignancies: a narrative review
Expression and clinical implications of estrogen receptors in thoracic malignancies: a narrative review Open
Thoracic malignancies represent a significant global health burden with incidence and mortality increasing year by year. Thoracic cancer prognosis and treatment options depend on several factors, including the type and size of the tumor, i…
View article: Specific low-frequency electromagnetic fields induce expression of active KDM6B associated with functional changes in U937 cells
Specific low-frequency electromagnetic fields induce expression of active KDM6B associated with functional changes in U937 cells Open
In this study, we investigated the effects of specific low-frequency electromagnetic field sequences on U937 cells, an in vitro model of human monocyte/macrophage differentiation. U937 cells were exposed to electromagnetic stimulati…
View article: Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition
Transglutaminase 2 maintains a colorectal cancer stem phenotype by regulating epithelial-mesenchymal transition Open
Transglutaminase 2 (TG2), a multifunctional protein, is reported in regulating the cancer stem cell (CSC) phenotype in various cancers. Our previous work suggested the link between TG2 and Epithelial-Mesenchymal Transition (EMT) in colorec…
View article: Specific low frequency electromagnetic fields induce epigenetic and\n functional changes in U937 cells
Specific low frequency electromagnetic fields induce epigenetic and\n functional changes in U937 cells Open
In this study, we investigated the effects of specific low frequency\nelectromagnetic fields sequences on U937 cells, an in vitro model of human\nmonocyte/macrophage differentiation. U937 cells were exposed to electromagnetic\nstimulation …
View article: Specific low frequency electromagnetic fields induce epigenetic and functional changes in U937 cells
Specific low frequency electromagnetic fields induce epigenetic and functional changes in U937 cells Open
In this study, we investigated the effects of specific low frequency electromagnetic fields sequences on U937 cells, an in vitro model of human monocyte/macrophage differentiation. U937 cells were exposed to electromagnetic stimulation by …
View article: Targeting estrogen receptor beta (ERβ) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ERβ expression and functionality
Targeting estrogen receptor beta (ERβ) for treatment of ovarian cancer: importance of KDM6B and SIRT1 for ERβ expression and functionality Open
View article: Expression and Therapeutic Significance of Estrogen Receptor β in Malignant Pleural Mesothelioma
Expression and Therapeutic Significance of Estrogen Receptor β in Malignant Pleural Mesothelioma Open
View article: Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia
Tissue transglutaminase (TG2) enables survival of human malignant pleural mesothelioma cells in hypoxia Open
View article: RETRACTED ARTICLE: KDM6B Histone Demethylase is an Epigenetic Regulator of Estrogen Receptor β Expression in Human Pleural Mesothelioma
RETRACTED ARTICLE: KDM6B Histone Demethylase is an Epigenetic Regulator of Estrogen Receptor β Expression in Human Pleural Mesothelioma Open
We report a strong positive correlation between the expression of KDM6B and ERβ in MPM tumors and cell lines. We describe that, in hypoxia, the HIF2α-KDM6B axis induces an epithelioid morphology and ERβ expression in biphasic MPM cells wit…
View article: SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells
SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells Open
In this report, we show that malignant pleural mesothelioma (MPM) patients whose tumors express high levels of AKT1 exhibit a significantly worse prognosis, whereas no significant correlation with AKT3 expression is observed. We provide da…
View article: Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells
Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells Open
Biphasic malignant pleural mesothelioma (MPM) is the second most common histotype of MPM. It is histologically characterized by the concomitant presence of epithelioid and sarcomatoid features, the latter associated with worse prognosis. I…