Giulia Renda
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View article: Revisiting type 2 myocardial infarction: Unmet clinical needs
Revisiting type 2 myocardial infarction: Unmet clinical needs Open
Cardiovascular disease is the most common cause of mortality and morbidity worldwide and acute coronary syndrome (ACS) is often the first clinical manifestation. Currently, the diagnosis of acute myocardial infarction (AMI) is based on the…
View article: Gender and Sex-related differences in Type 2 Myocardial Infarction: the undervalued side of a neglected disease
Gender and Sex-related differences in Type 2 Myocardial Infarction: the undervalued side of a neglected disease Open
Type 2 myocardial infarction (T2MI) occurs due to an imbalance between coronary blood supply and myocardial oxygen demand, leading to ischemia without the rupture of an atherosclerotic plaque, distinguishing it from Type 1 myocardial infar…
View article: Diagnostic and prognostic roles of endothelial- and platelet-derived extracellular vesicles in cardiovascular diseases
Diagnostic and prognostic roles of endothelial- and platelet-derived extracellular vesicles in cardiovascular diseases Open
Extracellular vesicles (EVs) are membrane-bound structures released by all cell types. They play a critical role in intercellular communication by transferring their cargo, comprising proteins, lipids, metabolites, RNAs, miRNAs, and DNA fr…
View article: Effect of hemodialysis membranes on endogenous thrombin potential in end stage renal disease patients
Effect of hemodialysis membranes on endogenous thrombin potential in end stage renal disease patients Open
Background Cardiovascular disease and thrombosis are the leading cause of death in chronic kidney disease (CKD) patients. The end stage renal disease patients undergoing hemodialysis (ESRD-HD) are predisposed to hemostatic dysfunction, als…
View article: Tracing Visual Expertise in <scp>ECG</scp> Interpretation: An Eye‐Tracking Pilot Study
Tracing Visual Expertise in <span>ECG</span> Interpretation: An Eye‐Tracking Pilot Study Open
Background Visual expertise is pivotal for accurate ECG interpretation. We aimed to identify and measure expertise‐based differences in visual search patterns, cognitive load, and diagnostic accuracy during ECG analysis using eye‐tracking …
View article: Practical guidance for management of atrial fibrillation in sports cardiology
Practical guidance for management of atrial fibrillation in sports cardiology Open
While regular physical activity generally confers cardiovascular benefits, prolonged intense exercise bouts may paradoxically increase the risk of AF. The evaluation and management of AF in athletes require a tailored, multidisciplinary ap…
View article: Hallmarks for Thrombotic and Hemorrhagic Risks in Chronic Kidney Disease Patients
Hallmarks for Thrombotic and Hemorrhagic Risks in Chronic Kidney Disease Patients Open
Chronic kidney disease (CKD) is a global health issue causing a significant health burden. CKD patients develop thrombotic and hemorrhagic complications, and cardiovascular diseases are associated with increased hospitalization and mortali…
View article: Current Antithrombotic Treatments for Cardiovascular Diseases: A Comprehensive Review
Current Antithrombotic Treatments for Cardiovascular Diseases: A Comprehensive Review Open
Antithrombotic therapies (ATT) play a pivotal role in the management of cardiovascular diseases, aiming to prevent ischemic events while maintaining a delicate balance with the patient’s bleeding risk. Typically, ATT can be classified into…
View article: Prevention of cardiotoxicity in childhood cancer survivors: In physical exercise, we trust
Prevention of cardiotoxicity in childhood cancer survivors: In physical exercise, we trust Open
In recent years, the mean survival rate of children after a cancer diagnosis has significantly improved. At the same time, a growing interest in short and long-term cardiovascular (CV) complications of cancer therapy, as well as long-term …
View article: Maternal-fetal dyad beyond the phenomenology of pregnancy: from primordial cardiovascular prevention on out, do not miss this boat!
Maternal-fetal dyad beyond the phenomenology of pregnancy: from primordial cardiovascular prevention on out, do not miss this boat! Open
Pregnancy represents a stress test for every woman's cardiovascular (CV) system, and a pre-existing maternal unfavorable cardio-metabolic phenotype can uncover both adverse pregnancy outcomes and the subsequent development of cardiovascula…
View article: Role of CES1 and ABCB1 Genetic Polymorphisms on Functional Response to Dabigatran in Patients with Atrial Fibrillation
Role of CES1 and ABCB1 Genetic Polymorphisms on Functional Response to Dabigatran in Patients with Atrial Fibrillation Open
Background: Dabigatran etexilate is a pro-drug hydrolyzed into dabigatran by carboxylesterases (CES) and is a substrate of the P-Glycoprotein encoded by the adenosine-triphosphate-binding cassette sub-family B member (ABCB)1 genes. We eval…
View article: NOT JUST A SIMPLE BIRTH: SPONTANEOUS CORONARY ARTERY DISSECTION IN A YOUNG MOTHER
NOT JUST A SIMPLE BIRTH: SPONTANEOUS CORONARY ARTERY DISSECTION IN A YOUNG MOTHER Open
A 33–year–old Caucasian woman with no cardiovascular history was admitted to the gynecology department due to a threat of preterm birth. During hospitalization, the patient experienced chest pain complicated by ventricular fibrillation. Re…
View article: A VERY COMPLEX CASE OF DORV TYPE FALLOT: A CASE REPORT
A VERY COMPLEX CASE OF DORV TYPE FALLOT: A CASE REPORT Open
Double outlet right ventricle (DORV) is a rare CHD characterized by ventriculoarterial connection in which both great arteries arise entirely or predominantly from the right ventricle. Its prevalence is 0.9% of all CHDs. Several chromosoma…
View article: STRESS–INDUCIBLE MYOCARDIAL ISCHEMIA DUE TO A VENTRICULO–CORONARY FISTULA: WHAT WE KNOW
STRESS–INDUCIBLE MYOCARDIAL ISCHEMIA DUE TO A VENTRICULO–CORONARY FISTULA: WHAT WE KNOW Open
Coronary fistulas represent communications that form between the coronary arteries and a heart chamber or a large vessel. The real incidence is not known as well as their real clinical impact. Typically congenital, they can also develop fo…
View article: PERMANENT JUNCTIONAL RECIPROCATING TACHYCARDIA: IT IS IMPORTANT TO KNOW HOW TO RECOGNIZE IT
PERMANENT JUNCTIONAL RECIPROCATING TACHYCARDIA: IT IS IMPORTANT TO KNOW HOW TO RECOGNIZE IT Open
Permanent junctional reciprocating tachycardia, also known as Coumel‘s tachycardia, is a rare form of supraventricular tachycardia that is usually incessant, characterised by retrograde conduction via an accessory pathway usually located i…
View article: A RARE GUCH AND PULMONARY HYPERTENSION: A SHORT STORY
A RARE GUCH AND PULMONARY HYPERTENSION: A SHORT STORY Open
A 44–year–old woman presented to emergency department with dyspnea and anasarca. No past history of cardiologic diseases. Physical exam was notable for jugular turgor, hepatomegaly, rales and tachy–arrhythmic tones. Laboratory tests showed…
View article: PERCUTANEOUS CORONARY INTERVENTIONS IN PATIENTS TREATED WITH ORAL ANTICOAGULANT THERAPY: BASELINE CLINICAL CHARACTERISTICS OF THE PERSEO REGISTRY
PERCUTANEOUS CORONARY INTERVENTIONS IN PATIENTS TREATED WITH ORAL ANTICOAGULANT THERAPY: BASELINE CLINICAL CHARACTERISTICS OF THE PERSEO REGISTRY Open
Background International guidelines recommend a dual antithrombotic therapy (DAT) with direct oral anticoagulant (DOAC) for patients on chronic oral anticoagulant therapy (OAT) undergoing percutaneous coronary intervention with stent impla…
View article: MYOCARDIAL INFARCTION DUE TO LEFT CIRCUMFLEX ARTERY OCCLUSION: A SUBTLE TROJAN HORSE
MYOCARDIAL INFARCTION DUE TO LEFT CIRCUMFLEX ARTERY OCCLUSION: A SUBTLE TROJAN HORSE Open
A 47–year–old man presented to the emergency department complaining of recurrent chest pain (CP) since the previous day. His medical history included active smoking and dyslipidemia. The ECG revealed sinus bradycardia (56 bpm) with widespr…
View article: A RARE CASE OF TYPE A AORTIC DISSECTION PRESENTING AS ACUTE STROKE: A DIAGNOSTIC CHALLENGE
A RARE CASE OF TYPE A AORTIC DISSECTION PRESENTING AS ACUTE STROKE: A DIAGNOSTIC CHALLENGE Open
A 60–year–old woman presented to the emergency department with acute left hemiplegia, not chest pains. Past medical history was significant for family history of aortic aneurysm, arterial hypertension. At brain–CT was reported hypodensity …
View article: A 20–YEAR FOLLOW–UP OF SUCCESSFUL SURGICAL MANAGEMENT OF DOUBLE–OUTLET RIGHT VENTRICLE WITH PULMONARY STENOSIS: A CASE REPORT
A 20–YEAR FOLLOW–UP OF SUCCESSFUL SURGICAL MANAGEMENT OF DOUBLE–OUTLET RIGHT VENTRICLE WITH PULMONARY STENOSIS: A CASE REPORT Open
A 25–year–old man, suffering from worsening exertional dyspnea for 4 months, was referred to our Cardiology Unit. The patient was previously diagnosed with a late diagnosis of double outlet right ventricle (DORV), as well as pulmonary sten…
View article: SEVERE MITRAL INSUFFICIENCY FROM RHEUMATIC DISEASE: A CASE REPORT
SEVERE MITRAL INSUFFICIENCY FROM RHEUMATIC DISEASE: A CASE REPORT Open
Acute rheumatic fever continues to be a major health problem in many parts of thw world. It’s more common in low–income or developing parts of the world. Antibiotics for bacterial infections may not be available in these areas. In develope…
View article: LEFT BUNDLE BRANCH BLOCK AND ACUTE CORONARY SYNDROME: WHAT IS THE ROLE OF MODIFIED SGARBOSSA–SMITH CRITERIA AND THE WELLENS‘ PATTERN?
LEFT BUNDLE BRANCH BLOCK AND ACUTE CORONARY SYNDROME: WHAT IS THE ROLE OF MODIFIED SGARBOSSA–SMITH CRITERIA AND THE WELLENS‘ PATTERN? Open
A 55–year–old man presented to the emergency room with intermittent chest pain that started the day before. His medical history included hypertension, and dyslipidemia. The initial electrocardiogram (ECG) showed sinus rhythm (75 bpm) with …
View article: Ex Vivo Antiplatelet Effects of Oral Anticoagulants
Ex Vivo Antiplatelet Effects of Oral Anticoagulants Open
Background: The impact of non-vitamin K antagonist oral anticoagulants (NOACs) on platelet function is still unclear. We conducted a comprehensive ex vivo study aimed at assessing the effect of the four currently marketed NOACs on platelet…