Giulia Trotta
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View article: Are reasons for first using cannabis associated with subsequent cannabis consumption (standard THC units) and psychopathology?
Are reasons for first using cannabis associated with subsequent cannabis consumption (standard THC units) and psychopathology? Open
Background Reasons for first using cannabis (RFUC) may influence later use patterns and mental health outcomes. However, limited research has explored self-medication versus social RFUCs in depth, and their associations with cannabis use p…
View article: Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and <scp>IQ</scp>: Findings From the <scp>EU</scp>‐<scp>GEI</scp> Multicentre Case–Control Study
Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and <span>IQ</span>: Findings From the <span>EU</span>‐<span>GEI</span> Multicentre Case–Control Study Open
Introduction Evidence suggests that childhood maltreatment affects cognitive performance in both patients with psychosis and community controls. However, the interplay between childhood maltreatment, post‐traumatic stress symptoms (PTSS), …
View article: Jumping to Conclusions and Facial Emotion Recognition in First-Episode Psychosis: Longitudinal Insights from the Gap Follow-Up Study.
Jumping to Conclusions and Facial Emotion Recognition in First-Episode Psychosis: Longitudinal Insights from the Gap Follow-Up Study. Open
These findings demonstrate that JTC and FER are stable in people with psychosis and controls. Therefore, they may serve as important treatment targets for early intervention in psychosis. Future research should integrate the potential role…
View article: Cannabis Use Cessation and the Risk of Psychotic Disorders: A Case–Control Analysis from the First Episode Case–Control EU-GEI WP2 Study: L’arrêt de l’utilisation du cannabis et le risque de troubles psychotiques: Une analyse cas-témoins tirée de l’étude cas-témoins EU-GEI WP2 centrée sur les premiers épisodes psychotiques
Cannabis Use Cessation and the Risk of Psychotic Disorders: A Case–Control Analysis from the First Episode Case–Control EU-GEI WP2 Study: L’arrêt de l’utilisation du cannabis et le risque de troubles psychotiques: Une analyse cas-témoins tirée de l’étude cas-témoins EU-GEI WP2 centrée sur les premiers épisodes psychotiques Open
Objectives To establish whether the risk of psychotic disorders in cannabis users changes with time following cannabis cessation using data from the European Network of National Networks studying Gene–Environment Interactions in Schizophre…
View article: The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach
The impact of childhood trauma and cannabis use on paranoia: a structural equation model approach Open
Background Childhood trauma is a well-established risk factor for psychosis, paranoia, and substance use, with cannabis being a modifiable environmental factor that exacerbates these vulnerabilities. This study examines the interplay betwe…
View article: A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders
A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders Open
Background Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to sup…
View article: Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study
Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study Open
Background Multiple genetic and environmental risk factors play a role in the development of both schizophrenia-spectrum disorders and affective psychoses. How they act in combination is yet to be clarified. Methods We analyzed 573 first e…
View article: The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies
The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies Open
Background The association between cannabis and psychosis is established, but the role of underlying genetics is unclear. We used data from the EU-GEI case-control study and UK Biobank to examine the independent and combined effect of heav…
View article: The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis
The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis Open
View article: Methylomic signature of current cannabis use in two first-episode psychosis cohorts
Methylomic signature of current cannabis use in two first-episode psychosis cohorts Open
The rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gai…
View article: Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents
Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents Open
Background The link between cannabis use and schizophrenia is well-established in epidemiological studies, especially among adolescents with early-onset use. However, this association in rodent models is less clear. This meta-analysis exam…
View article: The effect of polygenic risk score and childhood adversity experiences on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis
The effect of polygenic risk score and childhood adversity experiences on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis Open
Background Childhood adversity is associated with various clinical dimensions in psychosis; however, how genetic vulnerability shapes the adversity associated psychopathological signature is yet to be clarified. Methods Using data from the…
View article: Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study
Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study Open
Background Incidence of first-episode psychosis (FEP) varies substantially across geographic regions. Phenotypes of subclinical psychosis (SP), such as psychotic-like experiences (PLEs) and schizotypy, present several similarities with psy…
View article: Cannabis Use is Associated with Increased Risk of Violence; a Systematic Review and Meta-Analysis
Cannabis Use is Associated with Increased Risk of Violence; a Systematic Review and Meta-Analysis Open
View article: The role of interpersonal trauma and substance use in mental health: A large population-based study
The role of interpersonal trauma and substance use in mental health: A large population-based study Open
View article: Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents
Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents Open
Background The link between cannabis use and schizophrenia is well-established in epidemiological studies, especially among adolescents with early-onset use. However, this association in rodent models is less clear. This meta-analysis exam…
View article: What is the duration of untreated psychosis worldwide? – A meta-analysis of pooled mean and median time and regional trends and other correlates across 369 studies
What is the duration of untreated psychosis worldwide? – A meta-analysis of pooled mean and median time and regional trends and other correlates across 369 studies Open
Duration of untreated psychosis (DUP) has been associated with poor mental health outcomes. We aimed to meta-analytically estimate the mean and median DUP worldwide, evaluating also the influence of several moderating factors. This PRISMA/…
View article: Methylomic signature of current cannabis use in two first-episode psychosis cohorts
Methylomic signature of current cannabis use in two first-episode psychosis cohorts Open
The rising prevalence and legalization of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gai…
View article: The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study Open
View article: Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case–control study
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case–control study Open
Background Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been expl…
View article: The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case–control study
The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case–control study Open
Background While cannabis use is a well-established risk factor for psychosis, little is known about any association between reasons for first using cannabis (RFUC) and later patterns of use and risk of psychosis. Methods We used data from…
View article: Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis—findings from the EU-GEI study
Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis—findings from the EU-GEI study Open
View article: Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis – findings from the EU-GEI study
Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis – findings from the EU-GEI study Open
Studies conducted in psychotic disorders have shown that DNA-methylation (DNAm) is sensitive to the impact of Childhood Adversity (CA). However, whether it mediates the association between CA and psychosis is yet to be explored. Epigenome-…
View article: Association Between Childhood Adversity and Functional Outcomes in People With Psychosis: A Meta-analysis
Association Between Childhood Adversity and Functional Outcomes in People With Psychosis: A Meta-analysis Open
Background and Hypothesis Despite the accepted link between childhood adversity (CA) and psychotic disorders, evidence on the relationship between CA and poor functional outcome remains less consistent and has never been reviewed quantitat…
View article: Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study
Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study Open
Background Schizophrenia (SZ), bipolar disorder (BD) and depression (D) run in families. This susceptibility is partly due to hundreds or thousands of common genetic variants, each conferring a fractional risk. The cumulative effects of th…
View article: Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI)
Childhood Maltreatment, Educational Attainment, and IQ: Findings From a Multicentric Case-control Study of First-episode Psychosis (EU-GEI) Open
Background and hypothesis Evidence suggests that childhood maltreatment (ie, childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quot…
View article: Use of multiple Polygenic Risk Scores for distinguishing Schizophrenia-spectrum disorder and Affective psychosis categories; the EUGEI study
Use of multiple Polygenic Risk Scores for distinguishing Schizophrenia-spectrum disorder and Affective psychosis categories; the EUGEI study Open
Schizophrenia (SZ), Bipolar Disorder (BD) and Depression (D) run in families. This susceptibility is partly due to hundreds or thousands of common genetic variants, each conferring a fractional risk. The cumulative effects of the associate…
View article: Exploring the Interplay Between Adversity, Neurocognition, Social Cognition, and Functional Outcome in People With Psychosis: A Narrative Review
Exploring the Interplay Between Adversity, Neurocognition, Social Cognition, and Functional Outcome in People With Psychosis: A Narrative Review Open
History of adversity is associated with subsequent psychosis, and with a spectrum of cognitive alterations in individuals with psychosis. These cognitive features go from neurocognitive aspects as working memory and attention, to complex s…
View article: Association Between Specific Childhood Adversities and Symptom Dimensions in People With Psychosis: Systematic Review and Meta-Analysis
Association Between Specific Childhood Adversities and Symptom Dimensions in People With Psychosis: Systematic Review and Meta-Analysis Open
Despite the accepted link between childhood abuse and positive psychotic symptoms, findings between other adversities, such as neglect, and the remaining dimensions in people with psychosis have been inconsistent, with evidence not yet rev…
View article: Environmental Risk Factors in Bipolar Disorder and Psychotic Depression: A Systematic Review and Meta-Analysis of Prospective Studies
Environmental Risk Factors in Bipolar Disorder and Psychotic Depression: A Systematic Review and Meta-Analysis of Prospective Studies Open
Objective The aim of this systematic review and meta-analysis was to study the association between specific environmental risk factors (ERF) and later development of Bipolar disorder and Psychotic depression. Methods A systematic search of…