Giulio Berti
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View article: Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease
Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn's disease Open
Single cell RNA sequencing of human full thickness Crohn's disease (CD) small bowel resection specimens was used to identify potential therapeutic targets for stricturing (S) CD. Using an unbiased approach, 16 cell lineages were assigned w…
View article: Epigenetic and Metabolic Reprogramming of Fibroblasts in Crohn’s Disease Strictures Reveals Histone Deacetylases as Therapeutic Targets
Epigenetic and Metabolic Reprogramming of Fibroblasts in Crohn’s Disease Strictures Reveals Histone Deacetylases as Therapeutic Targets Open
Background and Aims No effective therapeutic intervention exists for intestinal fibrosis in Crohn’s disease [CD]. We characterized fibroblast subtypes, epigenetic and metabolic changes, and signalling pathways in CD fibrosis to inform futu…
View article: Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn’s disease
Single cell sequencing data identify distinct B cell and fibroblast populations in stricturing Crohn’s disease Open
We used human full thickness Crohn’s disease (CD) small bowel resection specimens and single cell RNA sequencing to identify potential therapeutic targets for stricturing (S)CD. Using an unbiased approach, 16 cell lineages were assigned wi…
View article: Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease
Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease Open
Intestinal fibrosis and stricture formation is an aggressive complication of Crohns disease (CD), linked to increased morbidity and costs. The present study investigates the contribution of Wingless-Int-1 (Wnt) signalling to intestinal fib…
View article: Immuno-<i>moodulin</i>: a new anxiogenic factor produced by autoimmune-prone T cells
Immuno-<i>moodulin</i>: a new anxiogenic factor produced by autoimmune-prone T cells Open
Patients suffering from autoimmune diseases are more susceptible to mental disorders yet, the existence of specific cellular and molecular mechanisms behind the co-morbidity of these pathologies is far from being fully elucidated. By gener…
View article: DOP20 Drugs that modulate histone acetylation disrupt TGF-β-signalling and reduce collagen I expression in models of stricturing Crohn’s disease
DOP20 Drugs that modulate histone acetylation disrupt TGF-β-signalling and reduce collagen I expression in models of stricturing Crohn’s disease Open
Stricturing Crohn’s disease (SCD) is associated with excess deposition of extracellular collagen, is not reversed by current medical therapies, and is a frequent indication for surgery. Acetylation of histone proteins is an important epige…
View article: P035 Pharmacological inhibition of the canonical WNT signalling pathway represents a potential novel therapy for fibrosis in Crohn’s disease
P035 Pharmacological inhibition of the canonical WNT signalling pathway represents a potential novel therapy for fibrosis in Crohn’s disease Open
Intestinal fibrosis and subsequent stricturing does not respond to current therapies and is the main indication for surgery in Crohn’s disease (CD). Complete understanding of the underlying molecular mechanisms of fibrosis is required to u…