Giuseppe Blasi
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View article: Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis
Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis Open
Importance Inflammation is increasingly implicated in the pathophysiology of mood and psychotic disorders. Integrating blood biomarkers and brain imaging may help uncover mechanistic pathways and guide targeted interventions. Objective To …
View article: Digital mental health in Italy: findings from the multicentric DIGIT-PSY study
Digital mental health in Italy: findings from the multicentric DIGIT-PSY study Open
Introduction Despite an increasing interest in upscaling the digitalization process in mental health care services, there is still a gap in a deeper knowledge of the main barriers and facilitators allowing a capillary and consolidated impl…
View article: Development and validation of genomic biotypes for schizophrenia susceptibility from multiple polygenic scores
Development and validation of genomic biotypes for schizophrenia susceptibility from multiple polygenic scores Open
Understanding the genetic architecture of schizophrenia (SCZ) is invaluable for the development of personalized treatment. In three independent cohorts, using an automated pipeline, we calculated 413 psychiatry-relevant polygenic scores. U…
View article: Altered Brain‐Behavior Association During Resting State is a Potential Psychosis Risk Marker
Altered Brain‐Behavior Association During Resting State is a Potential Psychosis Risk Marker Open
Alterations in cognitive and neuroimaging measures in psychosis may reflect altered brain‐behavior interactions patterns accompanying the symptomatic manifestation of the disease. Using graph connectivity‐based approaches, we tested the br…
View article: Illness-related variables and abnormalities of resting-state brain activity in schizophrenia
Illness-related variables and abnormalities of resting-state brain activity in schizophrenia Open
Background The development of neuroimaging biomarkers in patients with schizophrenia (SCZ) requires a refined clinical characterization. A limitation of the neuroimaging literature is the partial uptake of progress in characterizing diseas…
View article: Blunted brain responses to neutral faces in healthy first-degree relatives of patients with schizophrenia: an image-based fMRI meta-analysis
Blunted brain responses to neutral faces in healthy first-degree relatives of patients with schizophrenia: an image-based fMRI meta-analysis Open
Schizophrenia is characterized by the misattribution of emotional significance to neutral faces, accompanied by overactivations of the limbic system. To understand the disorder’s genetic and environmental contributors, investigating health…
View article: The interplay between mentalization, personality traits and burnout in psychiatry training: Results from a large multicenter controlled study
The interplay between mentalization, personality traits and burnout in psychiatry training: Results from a large multicenter controlled study Open
Background A better characterization of educational processes during psychiatry training is needed, both to foster personal resilience and occupational proficiency. Methods An adequate coverage of medical residents at the national level wa…
View article: A miR-137–Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing
A miR-137–Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing Open
The functional translation of miR-137 target gene expression linked with schizophrenia involves the neural substrates of emotion processing.
View article: Heritability of amygdala reactivity to angry faces and its replicable association with the schizophrenia risk locus of <i>miR-137</i>
Heritability of amygdala reactivity to angry faces and its replicable association with the schizophrenia risk locus of <i>miR-137</i> Open
Background: Among healthy participants, the interindividual variability of brain response to facial emotions is associated with genetic variation, including common risk variants for schizophrenia, a heritable brain disorder characterized b…
View article: Effect of anticholinergic burden on brain activity during Working Memory and real-world functioning in patients with schizophrenia
Effect of anticholinergic burden on brain activity during Working Memory and real-world functioning in patients with schizophrenia Open
Cognitive impairment has been associated with poor real-world functioning in patients with Schizophrenia. Previous studies have shown that pharmacological treatment with anticholinergic properties may contribute to cognitive impairment in …
View article: Changes in patterns of age-related network connectivity are associated with risk for schizophrenia
Changes in patterns of age-related network connectivity are associated with risk for schizophrenia Open
Alterations in fMRI-based brain functional network connectivity (FNC) are associated with schizophrenia (SCZ) and the genetic risk or subthreshold clinical symptoms preceding the onset of SCZ, which often occurs in early adulthood. Thus, a…
View article: Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions Open
Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with shifting clinical phenomena across the life span. We investigated the convergence of putative schizophrenia risk genes in brain coexpression network…
View article: Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study
Resting-State Brain Activity Dysfunctions in Schizophrenia and Their Associations with Negative Symptom Domains: An fMRI Study Open
The aim of the present study was to examine the neurobiological correlates of the two negative symptom domains of schizophrenia, the Motivational Deficit domain (including avolition, anhedonia, and asociality) and the Expressive Deficit do…
View article: Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-based fMRI Meta-analysis
Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-based fMRI Meta-analysis Open
Background Impaired emotion processing constitutes a key dimension of schizophrenia and a possible endophenotype of this illness. Empirical studies consistently report poorer emotion recognition performance in patients with schizophrenia a…
View article: Age-related network connectivity pattern changes are associated with risk for psychosis
Age-related network connectivity pattern changes are associated with risk for psychosis Open
Introduction Psychosis onset typically occurs during adolescence or early adulthood, coinciding with the latest stage of brain maturation. Alterations in brain functional connectivity (FC) accompany the emergence of psychiatric symptoms an…
View article: Using combined environmental–clinical classification models to predict role functioning outcome in clinical high-risk states for psychosis and recent-onset depression
Using combined environmental–clinical classification models to predict role functioning outcome in clinical high-risk states for psychosis and recent-onset depression Open
Background Clinical high-risk states for psychosis (CHR) are associated with functional impairments and depressive disorders. A previous PRONIA study predicted social functioning in CHR and recent-onset depression (ROD) based on structural…
View article: Rare schizophrenia risk variant burden is conserved in diverse human populations
Rare schizophrenia risk variant burden is conserved in diverse human populations Open
Schizophrenia is a chronic mental illness that is amongst the most debilitating conditions encountered in medical practice. A recent landmark schizophrenia study of the protein-coding regions of the genome identified a causal role for ten …
View article: Resting-state functional connectivity of the ventral tegmental area and negative symptom domains in subjects with schizophrenia
Resting-state functional connectivity of the ventral tegmental area and negative symptom domains in subjects with schizophrenia Open
Introduction Negative symptoms (NS) represent a core aspect of schizophrenia with a huge impact on real life functioning. Dysfunctions within the dopaminergic cortico-striatal circuits have been documented in subjects with schizophrenia (S…