Giuseppe Paolicelli
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View article: A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis
A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis Open
Multiple sclerosis is a debilitating autoimmune disease, characterized by chronic inflammation of the central nervous system. While the significance of the gut microbiome on multiple sclerosis pathogenesis is established, the underlining m…
View article: Aspergillus fumigatus tryptophan metabolic route differently affects host immunity
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity Open
View article: Using Lung Organoids to Investigate Epithelial Barrier Complexity and IL-17 Signaling During Respiratory Infection
Using Lung Organoids to Investigate Epithelial Barrier Complexity and IL-17 Signaling During Respiratory Infection Open
OPINION article Front. Immunol., 28 February 2019Sec. Microbial Immunology Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.00323
View article: Mast Cells Respond to Candida albicans Infections and Modulate Macrophages Phagocytosis of the Fungus
Mast Cells Respond to Candida albicans Infections and Modulate Macrophages Phagocytosis of the Fungus Open
Mast cells (MCs) are long-lived immune cells widely distributed at mucosal surfaces and are among the first immune cell type that can get in contact with the external environment. This study aims to unravel the mechanisms of reciprocal inf…
View article: The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface
The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface Open
Mast cells are increasingly being recognized as crucial cells in the response of the organism to environmental agents. Interestingly, the ability of mast cells to sense and respond to external cues is modulated by the microenvironment that…
View article: IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut
IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut Open
View article: Leucine-Rich Repeat Kinase 2 Controls the Ca2+/Nuclear Factor of Activated T Cells/IL-2 Pathway during Aspergillus Non-Canonical Autophagy in Dendritic Cells
Leucine-Rich Repeat Kinase 2 Controls the Ca2+/Nuclear Factor of Activated T Cells/IL-2 Pathway during Aspergillus Non-Canonical Autophagy in Dendritic Cells Open
The Parkinson's disease-associated protein, Leucine-rich repeat kinase 2 (LRRK2), a known negative regulator of nuclear factor of activated T cells (NFAT), is expressed in myeloid cells such as macrophages and dendritic cells (DCs) and is …
View article: Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis
Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis Open
Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome. Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act…
View article: Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics
Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics Open
Phagocytes fight fungi using canonical and noncanonical, also called LC3-associated phagocytosis (LAP), autophagy pathways. However, the outcomes of autophagy/LAP in shaping host immune responses appear to greatly vary depending on fungal …
View article: IL-9 and Mast Cells Are Key Players of Candida Albicans Commensalism and Pathogenesis in the Gut
IL-9 and Mast Cells Are Key Players of Candida Albicans Commensalism and Pathogenesis in the Gut Open
View article: The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways
The IL-17F/IL-17RC Axis Promotes Respiratory Allergy in the Proximal Airways Open
The interleukin 17 (IL-17) cytokine and receptor family is central to antimicrobial resistance and inflammation in the lung. Mice lacking IL-17A, IL-17F, or the IL-17RA subunit were compared with wild-type mice for susceptibility to airway…
View article: A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis
A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis Open