Giuseppe Seminara
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View article: Psychological and Physical Correlates After Gender-Affirming Mastectomy: Insights from a Case Report and Review of the Literature
Psychological and Physical Correlates After Gender-Affirming Mastectomy: Insights from a Case Report and Review of the Literature Open
Gender dysphoria stems from incongruence between gender identity and assigned sex, often causing significant distress related to breast anatomy in transmasculine individuals. Gender-affirming hormone therapy typically precedes mastectomy, …
View article: Obesity Is Associated with Larger Thyroid Nodules but Not with Malignant Cytology
Obesity Is Associated with Larger Thyroid Nodules but Not with Malignant Cytology Open
Background: Obesity has been proposed as a risk factor for differentiated thyroid carcinoma (DTC), though findings in the literature remain conflicting. While some studies suggest an association between elevated body mass index (BMI) and t…
View article: Field cancerization in women without conventional risk factors: insights from a case-cohort study
Field cancerization in women without conventional risk factors: insights from a case-cohort study Open
Background Field cancerization (FC) is a well-documented phenomenon in oral squamous cell carcinoma (OSCC), typically reported in patients with known risk habits such as tobacco and alcohol use. To date, limited evidence exists regarding F…
View article: Psychological Correlates after Gender-Affirming Mastectomy: Insights from a Case Report and Review of the Literature
Psychological Correlates after Gender-Affirming Mastectomy: Insights from a Case Report and Review of the Literature Open
Gender dysphoria stems from incongruence between gender identity and assigned sex, often causing significant distress related to breast anatomy in transmasculine individuals. Gender-affirming hormone therapy typically precedes mastectomy, …
View article: Oral squamous cell carcinoma vs. medication-related osteonecrosis of the jaw in patients assuming bone-modifying agents: a diagnostic challenge in a multi-hospital case series
Oral squamous cell carcinoma vs. medication-related osteonecrosis of the jaw in patients assuming bone-modifying agents: a diagnostic challenge in a multi-hospital case series Open
Background Despite advances in the diagnosis of oral squamous cell carcinoma (OSCC), most cases are diagnosed in advanced stages, influencing negatively the patient's prognosis. The absence of specific signs and symptoms contributes to the…
View article: Identification of Novel Genetic Variants in a Cohort of Congenital Hypogonadotropic Hypogonadism: Computational Analysis of Pathogenicity Predictions
Identification of Novel Genetic Variants in a Cohort of Congenital Hypogonadotropic Hypogonadism: Computational Analysis of Pathogenicity Predictions Open
Congenital hypogonadotropic hypogonadism (CHH) is a rare and heterogeneous genetic disorder with variable penetrance caused by GnRH deficiency, leading to delayed puberty and infertility. In 50–60% of cases, CHH is associated with non-repr…
View article: Oropharyngeal adverse drug reactions: knowledge, attitudes, and practice (KAP) among Italian healthcare professionals and students
Oropharyngeal adverse drug reactions: knowledge, attitudes, and practice (KAP) among Italian healthcare professionals and students Open
Introduction Pharmacovigilance plays a vital role in ensuring drug safety and protecting public health. Oropharyngeal adverse drug reactions (O-ADRs) are found to be under-reported, especially by oral health professionals, limiting the ide…
View article: Diagnosis and management of infertility in patients with polycystic ovary syndrome (PCOS): guidelines from the Italian Society of Human Reproduction (SIRU) and the Italian Centers for the Study and Conservation of Eggs and Sperm (CECOS Italy)
Diagnosis and management of infertility in patients with polycystic ovary syndrome (PCOS): guidelines from the Italian Society of Human Reproduction (SIRU) and the Italian Centers for the Study and Conservation of Eggs and Sperm (CECOS Italy) Open
The polycystic ovary syndrome (PCOS) is a multifaced disease of the reproductive age associated with several comorbidities including infertility. Very few documents regarding the management of the infertility in women with PCOS, including …
View article: Association Between Euthyroidism and Muscular Parameters in Adults with an Excess of Fat Mass: A Preliminary Study
Association Between Euthyroidism and Muscular Parameters in Adults with an Excess of Fat Mass: A Preliminary Study Open
Background/Objectives: Thyroid hormones (THs) are correlated with body composition regardless of the presence of thyroid dysfunctions, whereas little is known regarding THs’ influence on muscular fitness components. This cross-sectional st…
View article: Chemerin and Polycystic Ovary Syndrome: A Comprehensive Review of Its Role as a Biomarker and Therapeutic Target
Chemerin and Polycystic Ovary Syndrome: A Comprehensive Review of Its Role as a Biomarker and Therapeutic Target Open
Background: Chemerin, an adipokine implicated in inflammatory, metabolic, and adipogenic processes, has been detected in high serum concentration in women with polycystic ovary syndrome (PCOS) and seems to play a role in PCOS pathogenesis.…
View article: Adult-Onset Case of Female Idiopathic Hypogonadotropic Hypogonadism and Ataxia: Genetic Background
Adult-Onset Case of Female Idiopathic Hypogonadotropic Hypogonadism and Ataxia: Genetic Background Open
Adult-onset cases of idiopathic hypogonadotropic hypogonadism (IHH) are characterized by partial or normal puberty development until adolescence and by the impairment of the hypothalamic–pituitary–gonadal (HPG) axis in adulthood. WDR11 and…
View article: De La Chapelle Syndrome: Clinical and Physical Performance Implications
De La Chapelle Syndrome: Clinical and Physical Performance Implications Open
Gynecomastia in adolescence is a benign condition that mostly disappears spontaneously within approximately two years from onset. When it is associated with hypogonadism, it may suggest a disorder of sexual differentiation. We report the c…
View article: How histopathological diagnosis interacts with kidney ultrasound parameters to predict glomerular filtration rate
How histopathological diagnosis interacts with kidney ultrasound parameters to predict glomerular filtration rate Open
Background eGFR evaluation is a pivotal staging step in patients with chronic kidney disease (CKD), and renal ultrasound plays an important role in diagnosis, prognosis and progression of CKD. The role of the interaction between histopatho…
View article: Gynecomastia and Leydigioma: An Unexpected Case Report Outcome
Gynecomastia and Leydigioma: An Unexpected Case Report Outcome Open
We report a case of a 19-year-old male referred to the Endocrine Unit because of gynecomastia. Initial investigation revealed elevated levels of estradiol (E2) along with secondary hypogonadism (hypotestosteronemia and severe oligoasthenot…
View article: Oro-Dental Pharmacovigilance in the Digital Age: Promoting Knowledge, Awareness, and Practice in Italy through a Smart Combined System—A Conference at the 30th National Congress of the Italian College of University Professors of Dental Disciplines
Oro-Dental Pharmacovigilance in the Digital Age: Promoting Knowledge, Awareness, and Practice in Italy through a Smart Combined System—A Conference at the 30th National Congress of the Italian College of University Professors of Dental Disciplines Open
Adverse drug reactions (ADRs) represent a significant threat to patients’ safety in dentistry, necessitating proactive measures for prevention and treatment. However, identifying ADRs of dental and oral interest can be challenging, and und…
View article: Positive effects of dietary supplementation with nutraceuticals on male subclinical hypogonadism: a pilot study
Positive effects of dietary supplementation with nutraceuticals on male subclinical hypogonadism: a pilot study Open
The combination of unsupervised PA and nutraceutical supplement improves body composition, insulin sensitivity and TE production in overweight-obese men with metabolic hypogonadism. Further controlled studies in the long-term are warranted…
View article: Management of Persistent Erectile Dysfunction after COVID-19 Infection: An 18-Month Follow-Up Case Report
Management of Persistent Erectile Dysfunction after COVID-19 Infection: An 18-Month Follow-Up Case Report Open
The coronavirus disease 2019 (COVID-19) is an emerging pandemic caused by a novel coronavirus (SARS-CoV-2). Since December 2019 the new virus has spread all over the world and has become a major health problem also because of the public me…
View article: Clinical scoring systems for the risk of cardiovascular autonomic neuropathy in type 1 and type 2 diabetes: A simple tool
Clinical scoring systems for the risk of cardiovascular autonomic neuropathy in type 1 and type 2 diabetes: A simple tool Open
This study was aimed at developing a clinical risk score for cardiovascular autonomic neuropathy (CAN) for type 1 and type 2 diabetes. In a retrospective cross‐sectional one‐centre study in an unselected population, 115 participants with t…
View article: The risks associated with percutaneous native kidney biopsies: a prospective study
The risks associated with percutaneous native kidney biopsies: a prospective study Open
Background The known risks and benefits of native kidney biopsies are mainly based on the findings of retrospective studies. The aim of this multicentre prospective study was to evaluate the safety of percutaneous renal biopsies and quanti…
View article: Dalla medicina reattiva alla medicina di precisione
Dalla medicina reattiva alla medicina di precisione Open
In recent years, there has been increased awareness of a concept of medicine based on individual differences taking into consideration genetic variability, environment, characteristics of the microbiome and individual lifestyles. It makes …
View article: Nutrizione parenterale intradialitica in pazienti con malnutrizione moderata-severa: studio prospettico osservazionale multicentrico
Nutrizione parenterale intradialitica in pazienti con malnutrizione moderata-severa: studio prospettico osservazionale multicentrico Open
Dialysis patients have a wide range of pathologies that contribute to their frailty. Maintaining a good nutritional status is useful to prevent and treat the so-called Protein-Energy Wasting (PEW), a complex clinical-laboratory condition i…
View article: MP185CLINICAL-PATHOLOGICAL CORRELATIONS AND PROGNOSTIC FACTORS IN A SICILIAN COHORT OF IGAN PATIENTS: A MULTICENTER RETROSPECTIVE ANALYSIS
MP185CLINICAL-PATHOLOGICAL CORRELATIONS AND PROGNOSTIC FACTORS IN A SICILIAN COHORT OF IGAN PATIENTS: A MULTICENTER RETROSPECTIVE ANALYSIS Open
CONCLUSIONS: HBSP could upregulate the expression of GDNF in vivo.Persistent activation of the RAS/ERK signaling pathway might be involved in the renoprotection of GDNF, which might take effect in an autocrine mode.HBSP could also alleviat…