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View article: DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc <sub>1</sub>
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc <sub>1</sub> Open
New drugs for visceral leishmaniasis that are safe, low cost, and adapted to the field are urgently required. Despite concerted efforts over the last several years, the number of new chemical entities that are suitable for clinical develop…
View article: Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines Open
Novel 3,3'-disubstituted-5,5'-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites were recently discovered. To improve the pharmacokinetic properties of the triazine derivatives, a new structu…
View article: Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice
Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice Open
The mesenteric lymph nodes (MLN) are a key site for the generation of adaptive immune responses to gut-derived antigenic material and immune cells within the MLN contribute to the pathophysiology of a range of conditions including inflamma…
View article: Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans
Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans Open
The intestinal lymphatic system transports fluid, immune cells, dietary lipids, and highly lipophilic drugs from the intestine to the systemic circulation. These transport functions are important to health and when dysregulated contribute …
View article: Lymphatic Uptake of Liposomes after Intraperitoneal Administration Primarily Occurs via the Diaphragmatic Lymphatics and is Dependent on Liposome Surface Properties
Lymphatic Uptake of Liposomes after Intraperitoneal Administration Primarily Occurs via the Diaphragmatic Lymphatics and is Dependent on Liposome Surface Properties Open
Drugs are commonly administered via the intraperitoneal (IP) route to treat localized infections and cancers in patients and to test drug efficacy and toxicity in preclinical studies. Despite this, there remain large gaps in our understand…
View article: An examination of lymphatic drug delivery to treat acute and critical illnesses
An examination of lymphatic drug delivery to treat acute and critical illnesses Open
Acute diseases are characterised by a rapid onset of symptoms resulting in the need for intensive care. Globally ~20 million people per year are diagnosed with an acute disease and of these 30% die. Death results from a progression to orga…