Gláucia C. Furtado
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View article: Mechanisms of CD4-help that enhance anti-tumor responses 3246
Mechanisms of CD4-help that enhance anti-tumor responses 3246 Open
Description CD8 T cells are crucial in cancer immunotherapy, but CD4 T cells also impact outcomes. Our studies in hepatocellular carcinoma (HCC) patients suggested that response to PD-1 blockade was driven by the intratumoral expansion of …
View article: Prolonged antigen presentation in absence of CD4 T cells promotes reversible defects of helpless CD8 memory T cells across multiple host-pathogen systems 4320
Prolonged antigen presentation in absence of CD4 T cells promotes reversible defects of helpless CD8 memory T cells across multiple host-pathogen systems 4320 Open
Description Generation of functional CD8 T cell memory typically requires engagement of CD4 T cells. However, in certain scenarios, such as acutely-resolving infections, effector (TE) and subsequent memory (TM) CD8 T cell formation may app…
View article: Heterozygosity for Crohn’s Disease Risk Allele of<i>ATG16L1</i>Protects against Bacterial Infection
Heterozygosity for Crohn’s Disease Risk Allele of<i>ATG16L1</i>Protects against Bacterial Infection Open
The T300A substitution in ATG16L1 associated with Crohn’s Disease impairs autophagy, yet up to 50% of humans are heterozygous for this allele. Here we demonstrate that heterozygosity for the analogous substitution in mice ( Atg16L1 T316A )…
View article: Functional impairment of “helpless” CD8<sup>+</sup>memory T cells is transient and driven by prolonged but finite cognate antigen presentation
Functional impairment of “helpless” CD8<sup>+</sup>memory T cells is transient and driven by prolonged but finite cognate antigen presentation Open
SUMMARY Generation of functional CD8 + T cell memory typically requires engagement of CD4 + T cells. However, in certain scenarios, such as acutely-resolving viral infections, effector (T E ) and subsequent memory (T M ) CD8 + T cell forma…
View article: Functional Impairment of 'Helpless' CD8 &nbsp;Memory T Cells is Transient and Driven by Prolonged But Finite Cognate Antigen Presentation
Functional Impairment of 'Helpless' CD8 Memory T Cells is Transient and Driven by Prolonged But Finite Cognate Antigen Presentation Open
View article: Stress-activated brain-gut circuits disrupt intestinal barrier integrity and social behaviour
Stress-activated brain-gut circuits disrupt intestinal barrier integrity and social behaviour Open
Chronic stress underlies the etiology of both major depressive disorder (MDD) and irritable bowel syndrome (IBS), two highly prevalent and debilitating conditions with high rates of co-morbidity. However, it is not fully understood how the…
View article: P061 Response to anti-α4β7 therapy in Ulcerative colitis is associated with lymphoid aggregate attrition through impaired recruitment of naïve lymphocytes
P061 Response to anti-α4β7 therapy in Ulcerative colitis is associated with lymphoid aggregate attrition through impaired recruitment of naïve lymphocytes Open
Background Vedolizumab (VDZ) is a frontline drug for Ulcerative colitis (UC) and Crohn’s disease (CD) that targets integrin α4β7, a gut-homing receptor. Despite significant use, the mechanism(s) of action (MOA) of VDZ remain unclear. Metho…
View article: IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40
IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40 Open
The food colorant Red 40 is an environmental risk factor for colitis development in mice with increased expression of interleukin (IL)-23. This immune response is mediated by CD4 + T cells, but mechanistic insights into how these CD4 + T c…
View article: Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity Open
View article: Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections
Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections Open
View article: Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23 Open
View article: Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections
Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections Open
The enteric nervous system (ENS) controls several intestinal functions including motility and nutrient handling, which can be disrupted by infection-induced neuropathies or neuronal cell death. We investigated possible tolerance mechanisms…
View article: Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia
Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia Open
The Notch pathway is highly active in almost all patients with T-cell acute lymphoblastic leukemia (T-ALL), but the implication of Notch ligands in T-ALL remains underexplored. Methods: We used a genetic mouse model of Notch ligand …
View article: Skin expression of IL-23 drives the development of psoriasis and psoriatic arthritis in mice
Skin expression of IL-23 drives the development of psoriasis and psoriatic arthritis in mice Open
Psoriasis (PS) is a chronic skin inflammation. Up to 30% of the patients with PS develop psoriatic arthritis (PsA), a condition characterized by inflammatory arthritis that affects joints or entheses. Although there is mounting evidence fo…
View article: Intratumoral heterogeneity and clonal evolution in liver cancer
Intratumoral heterogeneity and clonal evolution in liver cancer Open
View article: Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23 Open
Neonatal inflammatory diseases are associated with severe morbidity, but the inflammatory factors underlying them and their potential effector mechanisms are poorly defined. Here we show that necrotizing enterocolitis in neonate mice is ac…
View article: Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of Epidermal Growth Factor Receptor–Dependent Serrated Polyps in Mouse Cecum
Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of Epidermal Growth Factor Receptor–Dependent Serrated Polyps in Mouse Cecum Open
View article: Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals Open
Anti-α4β7 integrin therapy results in attrition of lymphoid aggregates within the gastrointestinal tract of HIV-1–infected individuals with IBD.
View article: Interleukin 33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization
Interleukin 33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization Open
View article: Diet Modifies Colonic Microbiota and CD4+ T-Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-Cell Expression of Interleukin 23
Diet Modifies Colonic Microbiota and CD4+ T-Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-Cell Expression of Interleukin 23 Open
View article: Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals Open
Herein, we present the first human study of anti-α4β7 therapy in a cohort of HIV-1 infected subjects with mild inflammatory bowel disease. α4β7 + gut homing CD4 + T cells are early viral targets and contribute to HIV-1 pathogenesis, likely…
View article: Interleukin 22 mediates interleukin 23-induced pathology in newborn mice by disrupting the function of pancreatic and intestinal cells
Interleukin 22 mediates interleukin 23-induced pathology in newborn mice by disrupting the function of pancreatic and intestinal cells Open
Mice expressing IL-23 constitutively in the intestine or skin fail to grow and die prematurely. These phenotypes are associated with marked changes in the levels of circulating cytokines and with changes in the transcriptome of the pancrea…
View article: Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host Open
View article: IL-33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization
IL-33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization Open
IL-33 is a cytokine found in the extracellular space (mature IL-33) or in the cell nucleus (full-length IL-33). Nuclear accumulation of IL-33 has been reported in intestinal epithelial cells (IEC) during intestinal inflammation and cancer,…
View article: Diet Modifies Colonic Microbiota and CD4<sup>+</sup> T Cell Repertoire to Trigger Flares in a Novel Model of Colitis Induced by IL-23
Diet Modifies Colonic Microbiota and CD4<sup>+</sup> T Cell Repertoire to Trigger Flares in a Novel Model of Colitis Induced by IL-23 Open
A wealth of experimental data points to immunological and environmental factors in the pathogenesis of inflammatory bowel disease (IBD). Here we study the role of IL-23, the microbiome, and the diet in the development of colitis. To promot…
View article: Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice
Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice Open
Increased expression of Interleukin (IL)-33 has been detected in intestinal samples of patients with ulcerative colitis, a condition associated with increased risk for colon cancer, but its role in the development of colorectal cancer has …
View article: Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs
Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs Open
View article: CXCL1, but not IL-6, significantly impacts intraocular inflammation during infection
CXCL1, but not IL-6, significantly impacts intraocular inflammation during infection Open
During intraocular bacterial infections, the primary innate responders are neutrophils, which may cause bystander damage to the retina or perturb the clarity of the visual axis. We hypothesized that cytokine IL-6 and chemokine CXCL1 contri…
View article: Host and microbiota interactions are critical for development of murine Crohn's-like ileitis
Host and microbiota interactions are critical for development of murine Crohn's-like ileitis Open