Gláucio Valdameri
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View article: Machine Learning Models to Discriminate COVID-19 Severity with Biomarkers Available in Brazilian Public Health
Machine Learning Models to Discriminate COVID-19 Severity with Biomarkers Available in Brazilian Public Health Open
Despite advances in vaccination and treatment, the emergence of Long COVID cases has highlighted the continued public health concern posed by the disease. Studies on the early prediction of COVID-19 severity and the identification of assoc…
View article: Correction: Al-Lahham et al. Reference Interval for Glycated Albumin, 1,5-AG/GA, and GA/HbA1c Ratios and Cut-Off Values for Type 1, Type 2, and Gestational Diabetes: A Cross-Sectional Study. Biomedicines 2024, 12, 2651
Correction: Al-Lahham et al. Reference Interval for Glycated Albumin, 1,5-AG/GA, and GA/HbA1c Ratios and Cut-Off Values for Type 1, Type 2, and Gestational Diabetes: A Cross-Sectional Study. Biomedicines 2024, 12, 2651 Open
In the original publication [...]
View article: Effects of Cholesterol on the Breast Cancer Resistance Protein: Studies through the Synthesis and Biological Evaluation of Chemical Tools
Effects of Cholesterol on the Breast Cancer Resistance Protein: Studies through the Synthesis and Biological Evaluation of Chemical Tools Open
The breast cancer resistance protein (BCRP/ABCG2) plays a major role in the multidrug resistance of cancers toward chemotherapeutic treatments. It was demonstrated that cholesterol regulates the ABCG2 activity, suggesting that lower levels…
View article: Effective Mixed-Type Tissue Crusher and Simultaneous Isolation of RNA, DNA, and Protein from Solid Tissues Using a TRIzol-Based Method
Effective Mixed-Type Tissue Crusher and Simultaneous Isolation of RNA, DNA, and Protein from Solid Tissues Using a TRIzol-Based Method Open
One of the major challenges of studying biomarkers in tumor samples is the low quantity and quality of isolated RNA, DNA, and proteins. Additionally, the extraction methods ideally should obtain macromolecules from the same tumor biopsy, a…
View article: Polymorphisms in the SUMO4 Gene Region and Type 1 Diabetes Mellitus in Non-Asian Populations: A Scoping Review
Polymorphisms in the SUMO4 Gene Region and Type 1 Diabetes Mellitus in Non-Asian Populations: A Scoping Review Open
Type 1 diabetes mellitus (T1D) is a complex autoimmune disease resulting from pancreatic insulin-producing cell destruction. Numerous studies have investigated the association between the Small Ubiquitin-like Modifier 4 (SUMO4) gene and th…
View article: Reference Interval for Glycated Albumin, 1,5-AG/GA, and GA/HbA1c Ratios and Cut-Off Values for Type 1, Type 2, and Gestational Diabetes: A Cross-Sectional Study
Reference Interval for Glycated Albumin, 1,5-AG/GA, and GA/HbA1c Ratios and Cut-Off Values for Type 1, Type 2, and Gestational Diabetes: A Cross-Sectional Study Open
Background/Objectives: Glycated albumin (GA) serves as a biomarker for short-term glycemic control (2–3 weeks), playing a role in diabetes management. Our goal was to establish reference intervals (RIs) for serum GA, and the ratios of 1,5-…
View article: Evaluation of the pharmacognostic parameters, qualitative phytochemical profile and investigation of the toxicity of Sacoglottis ceratocarpa Ducke containing Bergenin, a gallic acid derivative
Evaluation of the pharmacognostic parameters, qualitative phytochemical profile and investigation of the toxicity of Sacoglottis ceratocarpa Ducke containing Bergenin, a gallic acid derivative Open
Trunk barks of Sacoglottis ceratocarpaDucke (ScTB) are used in Amazonian folk medicine against hyperglycemia and dyslipidemia, although scientific information on efficacy and quality control is lacking. Thus, pharmacognostic parameters, qu…
View article: G-CoV.2: A computational system for geolocation of patients diagnosed with COVID-19
G-CoV.2: A computational system for geolocation of patients diagnosed with COVID-19 Open
Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2). In the current scenario of COVID-19, more than 6 million people have died worldwide, and near seven hu…
View article: A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats
A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats Open
Diabetes mellitus (DM) complications are a burden to health care systems due to the associated consequences of poor glycemic control and the side effects of insulin therapy. Recently. adjuvant therapies, such as vanadium compounds, have ga…
View article: Serum profile of the anti-müllerian hormone of Nelore bulls in the peripuberty
Serum profile of the anti-müllerian hormone of Nelore bulls in the peripuberty Open
This study aimed to investigate the profile of AMH serum concentrations during the period of prepuberty in young bulls. The bulls were selected and evaluated for 150 days to assess their sexual development. The semen and blood collection, …
View article: Structural and molecular characterization of lopinavir and ivermectin as breast cancer resistance protein (BCRP/ABCG2) inhibitors
Structural and molecular characterization of lopinavir and ivermectin as breast cancer resistance protein (BCRP/ABCG2) inhibitors Open
A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the most important ABC transporters implicated in MDR and the use of …
View article: Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery
Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery Open
Inhibition of ABC transporters is a promising approach to overcome multidrug resistance in cancer. Herein, we report the characterization of a potent ABCG2 inhibitor, namely, chromone 4a (C4a). Molecular docking and in vitro assays using A…
View article: Data from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Data from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
The emergence of tumor resistance to conventional microtubule-targeting drugs restricts their clinical use. Using a cell-based assay that recognizes microtubule polymerization status to screen for chemicals that interact with regulators of…
View article: Supplementary Figure 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 212K, Effect of Pyr1 treatment on the number and on the size of EB1 comets in HeLa cells
View article: Supplementary Figure 4 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 4 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 252K, Effect of Pyr1 on NEK11 and MLK1 activity
View article: Supplementary Figure 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 212K, Effect of Pyr1 treatment on the number and on the size of EB1 comets in HeLa cells
View article: Supplementary Figure 5 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 5 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 487K, Effects of Pyr1 structural analogues on F-actin organization, on Detyr-microtubules generation, and on in cellulo cofilin phosphorylation
View article: Supplementary Figure 5 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 5 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 487K, Effects of Pyr1 structural analogues on F-actin organization, on Detyr-microtubules generation, and on in cellulo cofilin phosphorylation
View article: Supplementary Figure 4 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 4 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 252K, Effect of Pyr1 on NEK11 and MLK1 activity
View article: Supplementary Tables 1-9, Movie Legend, Methods from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Tables 1-9, Movie Legend, Methods from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 253K
View article: Supplementary Video 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Video 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
MOV file - 6MB, Effect of Pyr1 on microtubule dynamic instability - Time-lapse microscopy after 2 hours of incubation, on GFP-EB3 HeLa cells treated with DMSO (control), 5 muM, 10 muM or 25 muM Pyr1, as indicated. 4.Supplementary informati…
View article: Supplementary Figure 6 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 6 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 173K, Effect of LIMK down regulation on Detyr-tubulin levels
View article: Supplementary Figure 2 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 2 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 486K, Analysis of the consequence of actin filaments depolymerization on Pyr1 -induced formation of Detyr-microtubules
View article: Data from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Data from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
The emergence of tumor resistance to conventional microtubule-targeting drugs restricts their clinical use. Using a cell-based assay that recognizes microtubule polymerization status to screen for chemicals that interact with regulators of…
View article: Supplementary Video 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Video 1 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
MOV file - 6MB, Effect of Pyr1 on microtubule dynamic instability - Time-lapse microscopy after 2 hours of incubation, on GFP-EB3 HeLa cells treated with DMSO (control), 5 muM, 10 muM or 25 muM Pyr1, as indicated. 4.Supplementary informati…
View article: Supplementary Figure 3 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 3 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 173K, Characterization of Pyr1 (Pyr1) effects on the inhibition of LIMKs activity in vitro
View article: Supplementary Figure 2 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 2 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 486K, Analysis of the consequence of actin filaments depolymerization on Pyr1 -induced formation of Detyr-microtubules
View article: Supplementary Figure 6 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Supplementary Figure 6 from Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth Open
PDF file - 173K, Effect of LIMK down regulation on Detyr-tubulin levels