Glen E. Kellogg
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View article: Cholesterol-dependent enzyme activity of human TSPO1
Cholesterol-dependent enzyme activity of human TSPO1 Open
The amino acid sequence of the tryptophan-rich sensory proteins (TSPO) is substantially conserved throughout all kingdoms of life. Human mitochondrial TSPO1 ( Hs TSPO1) binds to porphyrins and steroids, although its interactions with these…
View article: A BPTF Inhibitor That Interferes with the Multidrug Resistance Pump to Sensitize Murine Triple-Negative Breast Cancer Cells to Chemotherapy
A BPTF Inhibitor That Interferes with the Multidrug Resistance Pump to Sensitize Murine Triple-Negative Breast Cancer Cells to Chemotherapy Open
Triple-negative breast cancer (TNBC) is associated with a generally poor prognosis due to its highly aggressive and metastatic nature, lack of targetable receptors, as well as the frequent development of resistance to chemotherapy. We prev…
View article: Three-Dimensional Interaction Homology: Deconstructing Residue–Residue and Residue–Lipid Interactions in Membrane Proteins
Three-Dimensional Interaction Homology: Deconstructing Residue–Residue and Residue–Lipid Interactions in Membrane Proteins Open
A method is described to deconstruct the network of hydropathic interactions within and between a protein’s sidechain and its environment into residue-based three-dimensional maps. These maps encode favorable and unfavorable hydrophobic an…
View article: A Bptf Inhibitor That Interferes with the Multidrug Resistance Pump to Sensitize Triple Negative Breast Cancer Cells to Chemotherapy
A Bptf Inhibitor That Interferes with the Multidrug Resistance Pump to Sensitize Triple Negative Breast Cancer Cells to Chemotherapy Open
Triple negative breast cancer (TNBC) is associated with a generally poor prognosis due to its highly aggressive and metastatic nature, lack of targetable receptors, as well as the frequent development of resistance to chemotherapy. We prev…
View article: Editorial: Computational methods for protein characterization: in memoriam of Donald Abraham
Editorial: Computational methods for protein characterization: in memoriam of Donald Abraham Open
EDITORIAL article Front. Mol. Biosci., 15 September 2023Sec. Protein Biochemistry for Basic and Applied Sciences Volume 10 - 2023 | https://doi.org/10.3389/fmolb.2023.1289441
View article: Nicotinamide riboside activates SIRT5 deacetylation
Nicotinamide riboside activates SIRT5 deacetylation Open
Human sirtuins play important roles in various cellular events including DNA repair, gene silencing, mitochondrial biogenesis, insulin secretion and apoptosis. They regulate a wide array of protein and enzyme targets through their NAD + ‐d…
View article: HINT, a code for understanding the interaction between biomolecules: a tribute to Donald J. Abraham
HINT, a code for understanding the interaction between biomolecules: a tribute to Donald J. Abraham Open
A long-lasting goal of computational biochemists, medicinal chemists, and structural biologists has been the development of tools capable of deciphering the molecule–molecule interaction code that produces a rich variety of complex biomole…
View article: 3D interaction homology: The hydrophobic residues alanine, isoleucine, leucine, proline and valine play different structural roles in soluble and membrane proteins
3D interaction homology: The hydrophobic residues alanine, isoleucine, leucine, proline and valine play different structural roles in soluble and membrane proteins Open
The aliphatic hydrophobic amino acid residues—alanine, isoleucine, leucine, proline and valine—are among the most common found in proteins. Their structural role in proteins is seemingly obvious: engage in hydrophobic interactions to stabi…
View article: Elucidating the Interaction between Pyridoxine 5′-Phosphate Oxidase and Dopa Decarboxylase: Activation of B6-Dependent Enzyme
Elucidating the Interaction between Pyridoxine 5′-Phosphate Oxidase and Dopa Decarboxylase: Activation of B6-Dependent Enzyme Open
Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, serves as a cofactor for scores of B6-dependent (PLP-dependent) enzymes involved in many cellular processes. One such B6 enzyme is dopa decarboxylase (DDC), which is required for…
View article: ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response
ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response Open
Ataxia telangiectasia mutated (ATM) is a serine–threonine protein kinase and important regulator of the DNA damage response (DDR). One critical ATM target is the structural subunit A (PR65–S401) of protein phosphatase 2A (PP2A), known to r…
View article: From oncoproteins to spike proteins: the evaluation of intramolecular stability using hydropathic force field
From oncoproteins to spike proteins: the evaluation of intramolecular stability using hydropathic force field Open
Evaluation of the intramolecular stability of proteins plays a key role in the comprehension of their biological behavior and mechanism of action. Small structural alterations such as mutations induced by single nucleotide polymorphism can…
View article: From oncoproteins to spike proteins: the evaluation of intramolecular stability using hydropathic force field
From oncoproteins to spike proteins: the evaluation of intramolecular stability using hydropathic force field Open
Evaluation of the intramolecular stability of proteins plays a key role in the comprehension of their biological behavior and mechanism of action. Small structural alterations such as mutations induced by single nucleotide polymorphism can…
View article: Additional file 2 of Novel eIF4A1 inhibitors with anti‐tumor activity in lymphoma
Additional file 2 of Novel eIF4A1 inhibitors with anti‐tumor activity in lymphoma Open
Additional file 2: Supplemental Table 1. Sequence of the primers and probes used. Supplemental Table 2. Compounds screened, their corresponding Molport ID and IUPAC names (screen 1). Supplemental Table 3. Compounds screened, their correspo…
View article: 3D Interaction Homology: Computational Titration of Aspartic Acid, Glutamic Acid and Histidine Can Create pH-Tunable Hydropathic Environment Maps
3D Interaction Homology: Computational Titration of Aspartic Acid, Glutamic Acid and Histidine Can Create pH-Tunable Hydropathic Environment Maps Open
Aspartic acid, glutamic acid and histidine are ionizable residues occupying various protein environments and perform many different functions in structures. Their roles are tied to their acid/base equilibria, solvent exposure, and backbone…
View article: ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response
ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response Open
Ataxia telangiectasia mutated (ATM) is a serine-threonine protein kinase and important regulator of the DNA damage response (DDR). One critical ATM target is the structural subunit A (PR65) of protein phosphatase 2A (PP2A), known to regula…
View article: Systematized analysis of secondary structure dependence of key structural features of residues in soluble and membrane-bound proteins
Systematized analysis of secondary structure dependence of key structural features of residues in soluble and membrane-bound proteins Open
Knowledge of three-dimensional protein structure is integral to most modern drug discovery efforts. Recent advancements have highlighted new techniques for 3D protein structure determination and, where structural data cannot be collected e…
View article: Synthesis, structure–affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: Structural factors contributing to selectivity
Synthesis, structure–affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: Structural factors contributing to selectivity Open
Histamine H1 and serotonin 5-HT2A receptors present in the CNS have been implicated in various neuropsychiatric disorders. 9-Aminomethyl-9,10-dihydroanthracene (AMDA), a conformationally constrained diarylalkyl amine derivative, has affini…
View article: Characterization and Discovery of a Selective Small-Molecule Modulator of Mitochondrial Complex I Targeting a Unique Binding Site
Characterization and Discovery of a Selective Small-Molecule Modulator of Mitochondrial Complex I Targeting a Unique Binding Site Open
Mitochondrial dysfunction has been recognized as an essential contributor to many human diseases including neurodegenerative disorders. However, the exact pathological role of mitochondrial dysfunction, especially in mitochondrial reactive…
View article: Correction: Functional diversification of the chemical landscapes of yeast Sec14-like phosphatidylinositol transfer protein lipid-binding cavities.
Correction: Functional diversification of the chemical landscapes of yeast Sec14-like phosphatidylinositol transfer protein lipid-binding cavities. Open
VOLUME 294 (2019) PAGES 19081–19098 A secondary affiliation for Marta G. Lete was inadvertently omitted. The missing affiliation is Institute Biofisika (UPV/EHU, CSIC) and University of the Basque Country, Leioa, Spain.
View article: Correction: Functional diversification of the chemical landscapes of yeast Sec14-like phosphatidylinositol transfer protein lipid-binding cavities.
Correction: Functional diversification of the chemical landscapes of yeast Sec14-like phosphatidylinositol transfer protein lipid-binding cavities. Open
VOLUME 294 (2019) PAGES 19081–19098 A secondary affiliation for Marta G. Lete was inadvertently omitted. The missing affiliation is Institute Biofisika (UPV/EHU, CSIC) and University of the Basque Country, Leioa, Spain.