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View article: P-1758. Evaluation of Real-Life Application of Multi-plex PCR Pneumonia Film-array Panel as an Antibiotic Stewardship Tool, a Prospective Investigation
P-1758. Evaluation of Real-Life Application of Multi-plex PCR Pneumonia Film-array Panel as an Antibiotic Stewardship Tool, a Prospective Investigation Open
Background Selecting empiric antibiotics (abx) for community-acquired and hospital-acquired pneumonia (CAP, HAP) on admission can be challenging, given the variety of possible pathogens. Per IDSA guidelines, broad spectrum antibiotic(s) ar…
View article: 633. Eravacycline Use in Immunocompromised Patients: Multicenter Evaluation of Clinical and Safety Endpoints
633. Eravacycline Use in Immunocompromised Patients: Multicenter Evaluation of Clinical and Safety Endpoints Open
Background Infections caused by multidrug-resistant (MDR) bacteria are an increasingly common public health threat associated with worse outcomes in immunocompromised patients. Eravacycline (ERV) has potent in-vitro activity against MDR Gr…
View article: Clinical Outcomes of Eravacycline in Patients Treated Predominately for Carbapenem-Resistant Acinetobacter baumannii
Clinical Outcomes of Eravacycline in Patients Treated Predominately for Carbapenem-Resistant Acinetobacter baumannii Open
Acinetobacter baumannii , particularly when carbapenem resistant (CRAB), is one of the most challenging pathogens in the health care setting. This is complicated by the fact that there is no consensus guideline regarding management of A. b…
View article: 225. Risk Factors for Mortality in Stenotrophomonas Bacteremia: A Retrospective Study
225. Risk Factors for Mortality in Stenotrophomonas Bacteremia: A Retrospective Study Open
Background Stenotrophomonas is a gram-negative organism typically associated with nosocomial infections. It is an emerging multi-drug resistant pathogen associated with significant morbidity and mortality in hospitalized patients. Optimal …
View article: 1288. Evaluation of Predictors for Clinical Success in Patients Treated with Eravacycline for Various Infections
1288. Evaluation of Predictors for Clinical Success in Patients Treated with Eravacycline for Various Infections Open
Background Eravacycline (ERV) is approved in the United States (US) for the treatment of complicated intra-abdominal infections in adults. We aimed to evaluate the independent predictors of clinical success in patients treated with ERV for…
View article: Bacterial coinfections with coronavirus disease 2019 (COVID-19)
Bacterial coinfections with coronavirus disease 2019 (COVID-19) Open
Background: The pandemic caused by severe acute respiratory coronavirus virus 2 (SARS-CoV-2) has dramatically increased cheshospitalizations, and it is often difficult to determine whether there is a bacterial or fungal coinfection at time…
View article: 1577. Real-World, Multicenter Experience with Eravacycline for Various Infections
1577. Real-World, Multicenter Experience with Eravacycline for Various Infections Open
Background Eravacycline (ERV) is Food and Drug Administration approved in patients for the treatment of adults complicated intra-abdominal infections in 2018. Real-world data regarding the indications for ERV use are is limited. We evaluat…
View article: 696. <i>Bartonella quintana</i> Endocarditis, A Case Series
696. <i>Bartonella quintana</i> Endocarditis, A Case Series Open
Background Homelessness has been a growing issue in the United States and worldwide. Bartonella quintana, the causative agent of “Trench fever”, is a well known illness among homeless populations in urban centers. While many cases of B. qu…
View article: 1560. Microbiology of Necrotizing Fasciitis and Implications on Antimicrobial Stewardship
1560. Microbiology of Necrotizing Fasciitis and Implications on Antimicrobial Stewardship Open
Background Necrotizing fasciitis (NF) is a rare but deadly soft tissue infection. Early diagnosis, antibiotics, and surgical management are critical in treatment. Current IDSA guidelines recommend broad empiric antibiotics (eg, vancomycin …
View article: 1109. Valgancyclovir Dosing for Cytomegalovirus Prophylaxis in Heart Transplant Recipients
1109. Valgancyclovir Dosing for Cytomegalovirus Prophylaxis in Heart Transplant Recipients Open
Background Cytomegalovirus (CMV) is one of the most common infections after transplantation and continues to cause significant morbidity and mortality. Current guidelines recommend 3-6 months of post-transplant prophylaxis with 900mg daily…
View article: Infective Endocarditis Guidelines: The Challenges of Adherence—A Survey of Infectious Diseases Clinicians
Infective Endocarditis Guidelines: The Challenges of Adherence—A Survey of Infectious Diseases Clinicians Open
Background Guidelines exist to aid clinicians in managing patients with infective endocarditis (IE), but the degree of adherence with guidelines by Infectious Disease (ID) physicians is largely unknown. Methods An electronic survey assessi…
View article: Elevated Liver Biochemistries in Hospitalized Chinese Patients With Severe COVID‐19: Systematic Review and Meta‐analysis
Elevated Liver Biochemistries in Hospitalized Chinese Patients With Severe COVID‐19: Systematic Review and Meta‐analysis Open
Background and Aims Several recent studies have reported an abnormal liver chemistry profile among patients with coronavirus disease 2019 (COVID‐19), although its clinical significance remains unknown. Approach and Results This systematic …
View article: Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity
Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity Open
To evaluate lymphopenia as a marker for coronavirus disease severity, we conducted a meta-analysis of 10 studies. Severe illness was associated with lower lymphocyte and higher leukocyte counts. Using these markers for early identification…
View article: Early Experience With Eravacycline for Complicated Infections
Early Experience With Eravacycline for Complicated Infections Open
Eravacycline (ERV) was used in 35 patients for various infections. The most common pathogen was Klebsiella pneumoniae, and 30-day survival was 74%. Absence of 30-day recurrence and resolution of signs and symptoms of infection were 91% and…
View article: 153. A Review of Ten Cases of Pulmonic Valve Infective Endocarditis
153. A Review of Ten Cases of Pulmonic Valve Infective Endocarditis Open
Background Pulmonic valve (PV) infective endocarditis (IE) is a rare entity, accounting for ~1.5–2% of all cases of IE. As a result, published literature describing the diagnosis and management of patients with PVIE is limited. Methods A r…
View article: 1448. Prostate Abscess: Clinical Features, Management, and Outcomes of a “Stealth” Infection: A Case Series
1448. Prostate Abscess: Clinical Features, Management, and Outcomes of a “Stealth” Infection: A Case Series Open
Background Prostate abscess (PA) is uncommon and the diagnosis is often delayed or missed. Traditionally, PA has resulted from acute prostatitis or ascending genitourinary (GU) infection due to gram-negative bacilli but S. aureus is an eme…
View article: Repeat Infective Endocarditis in Persons Who Inject Drugs: “Take Another Little Piece of my Heart”*
Repeat Infective Endocarditis in Persons Who Inject Drugs: “Take Another Little Piece of my Heart”* Open
Background Injection drug use (IDU) is a major risk factor for infective endocarditis (IE). Few data exist on repeat IE (rIE) in persons who inject drugs (PWID). Methods Patients ≥18 years old seen at Wake Forest Baptist Medical Center fro…
View article: 1021. Repeat Infective Endocarditis (rIE) in Persons Who Inject Drugs (PWID)
1021. Repeat Infective Endocarditis (rIE) in Persons Who Inject Drugs (PWID) Open
Background Injection drug use (IDU) is a major risk factor for infective endocarditis (IE). Rates of IE have recently increased in the US concurrent with the opioid crisis. Although IDU-related IE is well described, few data exist on repea…
View article: Genomic Characterization of Recrudescent<i>Plasmodium malariae</i>after Treatment with Artemether/Lumefantrine
Genomic Characterization of Recrudescent<i>Plasmodium malariae</i>after Treatment with Artemether/Lumefantrine Open
Plasmodium malariae is the only human malaria parasite species with a 72-hour intraerythrocytic cycle and the ability to persist in the host for life. We present a case of a P. malariae infection with clinical recrudescence after directly …
View article: The Impact of Diagnostic Stewardship on Clostridium difficile Infections
The Impact of Diagnostic Stewardship on Clostridium difficile Infections Open
Background Clostridium difficile infections (CDI) pose a growing threat to hospitalized patients. This study assesses the impact of changing from a nucleic acid amplification test (NAAT) to a stepwise testing algorithm (STA) by using an en…
View article: Prolonged Detection of Japanese Encephalitis Virus in Urine and Whole Blood in a Returned Short-term Traveler
Prolonged Detection of Japanese Encephalitis Virus in Urine and Whole Blood in a Returned Short-term Traveler Open
We describe a fatal case of Japanese encephalitis virus infection following short-term travel to Thailand. Viral RNA was detected in urine and whole blood out to 26 and 28 days, respectively, after the onset of symptoms. Live virus was iso…