Explanipedia

Somatosensory evoked potentials versus magnetospinography and magnetoneurography: is there a need for a new diagnostic modality in brachial plexus, cervical roots and spinal cord neurophysiology? Open

Pegah Afra, Glenn D. R. Watson · 2025

The electrical signals that pass through neuronal structures generate electrical currents and magnetic fields that can be measured by different electrography and magnetography modalities. In this article, we briefly review the fundamentals…

Is there room in epilepsy for the claustrum? Open

Glenn D. R. Watson, Stefano Meletti, Anil Mahavadi, Pierre Besson, S. Kathleen Bandt , et al. · 2024

The function of the claustrum and its role in neurological disorders remains a subject of interest in the field of neurology. Given the claustrum’s susceptibility to seizure-induced damage, there is speculation that it could serve as a nod…

The role of the parafascicular thalamic nucleus in action initiation and steering Open

Isabella P. Fallon, Ryan N. Hughes, Francesco Paolo Ulloa Severino, Namsoo Kim, Clara M. Lawry , et al. · 2023

Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement Open

Elijah A. Petter, Isabella P. Fallon, Ryan N. Hughes, Glenn D. R. Watson, Warren H. Meck , et al. · 2023

Animals can learn to repeat behaviors to earn desired rewards, a process commonly known as reinforcement learning. While previous work has implicated the ascending dopaminergic projections to the basal ganglia in reinforcement learning, li…

Author response: Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement Open

Elijah A. Petter, Isabella P. Fallon, Ryan N. Hughes, Glenn D. R. Watson, Warren H. Meck , et al. · 2023

Editorial: All roads lead to Rome: Harnessing thalamic neuromodulation for difficult-to-treat neurological disorders Open

Glenn D. R. Watson, Brian H. Kopell · 2023

EDITORIAL article Front. Hum. Neurosci., 14 February 2023Sec. Brain Imaging and Stimulation Volume 17 - 2023 | https://doi.org/10.3389/fnhum.2023.1155605

Elucidating a locus coeruleus-hippocampal dopamine pathway for operant reinforcement Open

Elijah A. Petter, Isabella P. Fallon, Ryan N. Hughes, Glenn D. R. Watson, Warren H. Meck , et al. · 2022

Animals can learn to repeat behaviors to earn desired rewards, a process commonly known as reinforcement learning. While previous work has implicated the ascending dopaminergic projections to the basal ganglia in reinforcement learning, li…

Editorial: Thalamic Interactions With the Basal Ganglia: Thalamostriatal System and Beyond Open

Jared B. Smith, Yoland Smith, Laurent Venance, Glenn D. R. Watson · 2022

International audience

A journey into the unknown: An ethnographic examination of drug-resistant epilepsy treatment and management in the United States Open

Glenn D. R. Watson, Pegah Afra, Luca Bartolini, Daniel A. Graf, Sanjeev V. Kothare , et al. · 2021

Patients often recognize unmet needs that can improve patient-provider experiences in disease treatment management. These needs are rarely captured and may be hard to quantify in difficult-to-treat disease states such as drug-resistant epi…

Precise coordination of three-dimensional rotational kinematics by ventral tegmental area GABAergic neurons Open

Ryan N. Hughes, Glenn D. R. Watson, Elijah A. Petter, Namsoo Kim, Konstantin I. Bakhurin , et al. · 2021

Thalamic projections to the subthalamic nucleus contribute to movement initiation and rescue of parkinsonian symptoms Open

Glenn D. R. Watson, Ryan N. Hughes, Elijah A. Petter, Isabella P. Fallon, Namsoo Kim , et al. · 2021

Selective activation of Pf-STN pathway initiates actions in normal mice and restores movement in a mouse model of PD.

Hypothalamic-Extended Amygdala Circuit Regulates Temporal Discounting Open

Haofang E. Li, Mark A. Rossi, Glenn D. R. Watson, Harvey G. Moore, Min Cai , et al. · 2021

Choice behavior is characterized by temporal discounting, i.e., preference for immediate rewards given a choice between immediate and delayed rewards. Agouti-related peptide (AgRP)-expressing neurons located in the arcuate nucleus of the h…

Probing Causality of the Brainstem-Hypothalamic Murine Models of Sleep-Wake Regulation Open

Fatemeh Bahari, Myles W. Billard, John Kimbugwe, Carlos M. Curay, Glenn D. R. Watson , et al. · 2020

Sleep-wake regulation is thought to be governed by interactions among several nuclei in midbrain, pons, and hypothalamic regions. Determination of the causal role of these nuclei in state transitions requires simultaneous measurements from…

Ventral Tegmental Dopamine Neurons Control the Impulse Vector during Motivated Behavior Open

Ryan N. Hughes, Konstantin I. Bakhurin, Elijah A. Petter, Glenn D. R. Watson, Namsoo Kim , et al. · 2020

Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways Open

Konstantin I. Bakhurin, Xiaoran Li, Alexander Friedman, Nicholas A. Lusk, Glenn D. R. Watson , et al. · 2020

The basal ganglia have been implicated in action selection and timing, but the relative contributions of the striatonigral (direct) and striatopallidal (indirect) pathways to these functions remain unclear. We investigated the effects of o…

Author response: Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways Open

Konstantin I. Bakhurin, Xiaoran Li, Alexander Friedman, Nicholas A. Lusk, Glenn D. R. Watson , et al. · 2020

Ventral tegmental dopamine neurons control the impulse vector during motivated behavior Open

Ryan N. Hughes, Konstantin I. Bakhurin, Elijah A. Petter, Glenn D. R. Watson, Namsoo Kim , et al. · 2020

The Ventral Tegmental Area (VTA) is a major source of dopamine, especially to the limbic brain regions. Despite decades of research, the function of VTA dopamine neurons remains controversial. Here, using a novel head-fixed behavioral syst…

Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways Open

Konstantin I. Bakhurin, Xiaoran Li, Alexander Friedman, Nicholas A. Lusk, Glenn D. R. Watson , et al. · 2019

The basal ganglia have been implicated in action selection and timing, but the relative contributions of the striatonigral (direct) and striatopallidal (indirect) pathways to these functions remain unclear. We investigated the effects of o…

Precise Coordination of Three-Dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons Open

Ryan N. Hughes, Glenn D. R. Watson, Elijah A. Petter, Namsoo Kim, Konstantin I. Bakhurin , et al. · 2019

Precise Coordination of 3-dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons Open

Ryan N. Hughes, Glenn D. R. Watson, Elijah A. Petter, Namsoo Kim, Konstantin I. Bakhurin , et al. · 2019

Summary The Ventral Tegmental Area (VTA) is a midbrain region implicated in a variety of motivated behaviors. However, the function of VTA GABAergic (Vgat+) neurons remains poorly understood. Here, using 3D motion capture, in vivo electrop…

A striatal interneuron circuit for continuous target pursuit Open

Namsoo Kim, Haofang E. Li, Ryan N. Hughes, Glenn D. R. Watson, David A. Gallegos , et al. · 2019

Most adaptive behaviors require precise tracking of targets in space. In pursuit behavior with a moving target, mice use distance to target to guide their own movement continuously. Here, we show that in the sensorimotor striatum, parvalbu…

A Role for the Claustrum in Salience Processing? Open

Jared B. Smith, Glenn D. R. Watson, Zhifeng Liang, Yikang Liu, Nanyin Zhang , et al. · 2019

The claustrum (CLA) is a subcortical structure, present only in mammals, whose function remains uncertain. Previously, using resting-state functional magnetic resonance imaging (rs-fMRI) in awake head-fixed rats, we found evidence that the…

Hypothalamic-extended amygdala circuit regulates temporal discounting Open

Mark A. Rossi, Haofang E. Li, Glenn D. R. Watson, Harvey G. Moore, Min Cai , et al. · 2019

Choice behavior is characterized by temporal discounting, i.e., preference for immediate rewards over delayed rewards. Temporal discounting is often dysfunctional in psychiatric disorders, addiction, and eating disorders. However, the unde…

The relationship between the claustrum and endopiriform nucleus: A perspective towards consensus on cross‐species homology Open

Jared B. Smith, Kevin D. Alloway, Patrick R. Hof, Rena Orman, David H. Reser , et al. · 2018

With the emergence of interest in studying the claustrum, a recent special issue of the Journal of Comparative Neurology dedicated to the claustrum (Volume 525, Issue 6, pp. 1313–1513) brought to light questions concerning the relationship…

A diencephalic pathway for movement initiation and rescue of Parkinsonian symptoms Open

Glenn D. R. Watson, Ryan N. Hughes, Elijah A. Petter, Henry H. Yin · 2018

Summary The parafascicular nucleus (Pf) of the thalamus projects to the subthalamic nucleus (STN), a major target for deep brain stimulation (DBS) in Parkinson’s disease (PD), but the function of this projection remains unknown. Here, we u…

Nigrotectal Stimulation Stops Interval Timing in Mice Open

Koji Toda, Nicholas A. Lusk, Glenn D. R. Watson, Namsoo Kim, Dongye Lu , et al. · 2017

Sensory Processing in the Dorsolateral Striatum: The Contribution of Thalamostriatal Pathways Open

Kevin D. Alloway, Jared B. Smith, Todd M. Mowery, Glenn D. R. Watson · 2017

The dorsal striatum has two functionally-defined subdivisions: a dorsomedial striatum (DMS) region involved in mediating goal-directed behaviors that require conscious effort, and a dorsolateral striatum (DLS) region involved in the execut…

Simultaneous GCaMP6-based fiber photometry and fMRI in rats Open

Zhifeng Liang, Yuncong Ma, Glenn D. R. Watson, Nanyin Zhang · 2017

Simultaneous GCaMP6-based Fiber Photometry and fMRI in Rats Open

Zhifeng Liang, Yuncong Ma, Glenn D. R. Watson, Nanyin Zhang · 2017

Understanding the relationship between neural and vascular signals is essential for interpretation of functional MRI (fMRI) results with respect to underlying neuronal activity. Simultaneously measuring neural activity using electrophysiol…

Interhemispheric connections between the infralimbic and entorhinal cortices: The endopiriform nucleus has limbic connections that parallel the sensory and motor connections of the claustrum Open

Glenn D. R. Watson, Jared B. Smith, Kevin D. Alloway · 2016

We have previously shown that the claustrum is part of an interhemispheric circuit that interconnects somesthetic–motor and visual–motor cortical regions. The role of the claustrum in processing limbic information, however, is poorly under…

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