Explanipedia

Prostate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism Open

Shalender Bhasin, Thomas G. Travison, Karol M. Pencina, Michael P. O’Leary, Glenn R. Cunningham , et al. · 2023

Importance The effect of testosterone replacement therapy (TRT) on the risk of prostate cancer and other adverse prostate events is unknown. Objective To compare the effect of TRT vs placebo on the incidences of high-grade prostate cancers…

MEASUR - Manufacturing Energy Assessment Software for Utility Reduction Open

Gina Accawi, Robert Mark Root, Nick Blondheim, Dmitry Howard, Rachel Hernández , et al. · 2022

MEASUR your energy savings with the free DOE MEASUR software The Department of Energy (DOE), with Oak Ridge National Laboratory (ORNL), released version 1.0 of their energy efficiency software tool MEASUR (Manufacturing Energy Assessment S…

Effects of long-term testosterone treatment on cardiovascular outcomes in men with hypogonadism: Rationale and design of the TRAVERSE study Open

Shalender Bhasin, A. Michael Lincoff, Shehzad Basaria, Douglas C. Bauer, William E. Boden , et al. · 2021

The TRAVERSE study will determine the CV safety and long-term efficacy of testosterone treatment in middle-aged and older men with hypogonadism with or at increased risk of CV disease.

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease Open

Ajay Nehra, Graham Jackson, Martin Miner, Kevin L. Billups, Arthur L. Burnett , et al. · 2020

The Princeton Consensus (Expert Panel) Conference is a multispecialty collaborative tradition dedicated to optimizing sexual function and preserving cardiovascular health. The third Princeton Consensus met November 8 to 10, 2010, and had 2…

Biomarkers and Noncalcified Coronary Artery Plaque Progression in Older Men Treated With Testosterone Open

Kashif Shaikh, Susan S. Ellenberg, Rine Nakanishi, Peter J. Snyder, Juhwan Lee , et al. · 2019

Objective Recent results from the Cardiovascular Trial of the Testosterone Trials showed that testosterone treatment of older men with low testosterone was associated with greater progression of noncalcified plaque (NCP). We evaluated the …

Prostate-Specific Antigen Levels During Testosterone Treatment of Hypogonadal Older Men: Data from a Controlled Trial Open

Glenn R. Cunningham, Susan S. Ellenberg, Shalender Bhasin, Alvin M. Matsumoto, J. Kellogg Parsons , et al. · 2019

Context Prostate-specific antigen (PSA) changes during testosterone treatment of older hypogonadal men have not been rigorously evaluated. Design Double-blinded, placebo-controlled trial. Setting Twelve US academic medical centers. Partici…

Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials Open

Shalender Bhasin, Susan S. Ellenberg, Thomas W. Storer, Shehzad Basaria, Marco Pahor , et al. · 2018

Lessons From the Testosterone Trials Open

Peter J. Snyder, Shalender Bhasin, Glenn R. Cunningham, Alvin M. Matsumoto, Alisa J. Stephens‐Shields , et al. · 2018

The Testosterone Trials (TTrials) were a coordinated set of seven placebo-controlled, double-blind trials in 788 men with a mean age of 72 years to determine the efficacy of increasing the testosterone levels of older men with low testoste…

The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials Open

Emile R. Mohler, Susan S. Ellenberg, Cora E. Lewis, Nanette K. Wenger, Matthew J. Budoff , et al. · 2017

Context Studies of the possible cardiovascular risk of testosterone treatment are inconclusive. Objective To determine the effect of testosterone treatment on cardiovascular biomarkers in older men with low testosterone. Design Double-blin…

Quality of Life and Sexual Function Benefits of Long-Term Testosterone Treatment: Longitudinal Results From the Registry of Hypogonadism in Men (RHYME) Open

Raymond C. Rosen, Frederick C. W. Wu, Hermann M. Behre, Hartmut Porst, E.J.H. Meuleman , et al. · 2017

Background The benefits and risks of long-term testosterone administration have been a topic of much scientific and regulatory interest in recent years. Aim To assess long-term quality of life (QOL) and sexual function benefits of testoste…

Association of Testosterone Levels With Anemia in Older Men Open

Cindy N. Roy, Peter J. Snyder, Alisa J. Stephens‐Shields, Andrew Artz, Shalender Bhasin , et al. · 2017

clinicaltrials.gov Identifier: NCT00799617.

Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone Open

Peter J. Snyder, David L. Kopperdahl, Alisa J. Stephens‐Shields, Susan S. Ellenberg, Jane A. Cauley , et al. · 2017

clinicaltrials.gov Identifier: NCT00799617.

COGNITIVE ASSESSMENT IN THE REAL WORLD: UNOBTRUSIVE MEASUREMENT OF DRIVING BEHAVIOR IN OLDER ADULTS Open

Adriana Seelye, Nora Mattek, Nicole Sharma, Thomas Riley, B Davis-Bloom , et al. · 2016

risk' (n = 88) were less safe than those who were cognitively healthy (n = 216).Results: Of the cognitively healthy group, (12.5%) were assessed as unsafe drivers during an on-road test and likely to fail a formal driving test based on cri…

Testosterone treatment is not associated with increased risk of adverse cardiovascular events: results from the Registry of Hypogonadism in Men (RHYME) Open

Mario Maggi, Frederick C. W. Wu, T. Hugh Jones, Graham Jackson, Hermann M. Behre , et al. · 2016

Age and prior CV history, not TRT use, were predictors of new-onset CV events in this multi-national, prospective hypogonadism registry.

Testosterone treatment is not associated with increased risk of prostate cancer or worsening of lower urinary tract symptoms: prostate health outcomes in the Registry of Hypogonadism in Men Open

F.M.J. Debruyne, Hermann M. Behre, Claus G. Roehrborn, Mario Maggi, Frederick C. W. Wu , et al. · 2016

Objectives To evaluate the effects of testosterone‐replacement therapy ( TRT ) on prostate health indicators in hypogonadal men, including rates of prostate cancer diagnoses, changes in prostate‐specific antigen ( PSA ) levels and lower ur…

Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels Open

Glenn R. Cunningham, Alisa J. Stephens‐Shields, Raymond C. Rosen, Christina Wang, Shalender Bhasin , et al. · 2016

Context: The Testosterone Trials are a coordinated set of seven trials to determine the efficacy of T in symptomatic men ≥65 years old with unequivocally low T levels. Initial results of the Sexual Function Trial showed that T improved sex…

Effects of Testosterone Treatment in Older Men Open

Peter J. Snyder, Shalender Bhasin, Glenn R. Cunningham, Alvin M. Matsumoto, Alisa J. Stephens‐Shields , et al. · 2016

In symptomatic men 65 years of age or older, raising testosterone concentrations for 1 year from moderately low to the mid-normal range for men 19 to 40 years of age had a moderate benefit with respect to sexual function and some benefit w…

Comparison of interactive voice response (IVR) with paper administration of instruments to assess functional status, sexual function, and quality of life in elderly men Open

Raymond C. Rosen, Alisa J. Stephens‐Shields, Glenn R. Cunningham, Denise Cifelli, David Cella , et al. · 2015

Recruitment and Screening for the Testosterone Trials Open

Jane A. Cauley, Laura Fluharty, Susan S. Ellenberg, Thomas M. Gill, Kristine E. Ensrud , et al. · 2015

Despite the telephone screening to enrollment ratio of 65 to 1, we met the recruitment goals for each trial. Recruitment of symptomatic older men with low testosterone levels is difficult but feasible.

Erratum Open

Peter J. Snyder, Susan S. Ellenberg, Glenn R. Cunningham, Alvin M. Matsumoto, Shalender Bhasin , et al. · 2015

CLINICAL TRIALS DESIGN Clinical Trials 2014; 11: 362–375 The Testosterone Trials: Seven coordinated trials of testosterone treatment in elderly men Peter J Snyder a , Susan S Ellenberg b , Glenn R Cunningham c , Alvin M Matsumoto d , Shale…

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