Guanhui Wu
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View article: Cerebrovascular compromise and cognitive decline driven by chronic heart failure
Cerebrovascular compromise and cognitive decline driven by chronic heart failure Open
Objective This study investigated the effects of chronic heart failure with decreased LVEF on small cerebral vascular disease (CSVD) and associated cognitive impairment. Methods This study encompassed a cohort of 73 patients diagnosed with…
View article: Electroencephalography Alpha Traveling Waves as Early Predictors of Treatment Response in Major Depressive Episodes: Insights from Intermittent Photic Stimulation
Electroencephalography Alpha Traveling Waves as Early Predictors of Treatment Response in Major Depressive Episodes: Insights from Intermittent Photic Stimulation Open
Background: Early evaluation of treatment efficacy in adolescents and young adults with major depressive episodes (MDEs) remains a clinical challenge, often delaying timely therapeutic adjustments. Electroencephalography (EEG) alpha travel…
View article: Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication
Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication Open
Regulator of telomere length 1 (RTEL1) helicase facilitates telomere replication by disassembling DNA secondary structures, such as G-quadruplexes and telomeric loops (t-loops), at the ends of the chromosomes. The recruitment of RTEL1 to t…
View article: Functional MRI study of neurovascular coupling in patients with non-lesional epilepsy
Functional MRI study of neurovascular coupling in patients with non-lesional epilepsy Open
Objective The diagnosis of patients with non-lesional epilepsy (NLE) is relatively challenging because of the absence of a clear focus on imaging, and the underlying pathological mechanism remains unclear. The neuronal activity and functio…
View article: Euthyroid sick syndrome predicts the risk of ischemic stroke-associated pneumonia in the acute stage of ischemic stroke: a nested case-control study
Euthyroid sick syndrome predicts the risk of ischemic stroke-associated pneumonia in the acute stage of ischemic stroke: a nested case-control study Open
Objective Ischemic stroke-associated pneumonia (iSAP) affects about 10% of acute ischemic stroke patients during hospitalization. Current prediction scales for iSAP are insufficient. Identifying early biomarkers for stroke-associated pneum…
View article: Altered brain networks and connections in chronic heart failure patients complicated with cognitive impairment
Altered brain networks and connections in chronic heart failure patients complicated with cognitive impairment Open
Objective Accumulating evidence shows that cognitive impairment (CI) in chronic heart failure (CHF) patients is related to brain network dysfunction. This study investigated brain network structure and rich-club organization in chronic hea…
View article: Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients
Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients Open
Introduction Accumulating evidence shows that epilepsy is a disease caused by brain network dysfunction. This study explored changes in brain network structure in epilepsy patients based on graph analysis of diffusion tensor imaging data. …
View article: Study of brain network alternations in non-lesional epilepsy patients by BOLD-fMRI
Study of brain network alternations in non-lesional epilepsy patients by BOLD-fMRI Open
Objective To investigate the changes of brain network in epilepsy patients without intracranial lesions under resting conditions. Methods Twenty-six non-lesional epileptic patients and 42 normal controls were enrolled for BOLD-fMRI examina…
View article: A tract-based spatial statistics study of white matter integrity in epilepsy
A tract-based spatial statistics study of white matter integrity in epilepsy Open
Objective To investigate the changes of cerebral white matter diffusion tensor in epilepsy patients based on the method of tract-based spatial statistics (TBSS). Methods Twenty-six patients with epilepsy and 42 healthy volunteers matched f…
View article: Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson’s Disease
Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson’s Disease Open
Parkinson’s disease (PD) is the most common movement disorder and the second most prevalent neurodegenerative disease after Alzheimer’s disease. Despite decades of research, there is still no cure for PD and the complicated intricacies of …
View article: Effect of cognitive behavioral intervention on anxiety, depression, and quality of life in patients with epilepsy.
Effect of cognitive behavioral intervention on anxiety, depression, and quality of life in patients with epilepsy. Open
Increases in overall scores, seizure worry, cognitive functioning, and medication effect were better in the CBT group. CBT can improve anxiety, depression, and quality of life in patients with epilepsy. Women and combined-drug patients wit…
View article: RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes
RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes Open
Objective RNA helicase DDX5 is downregulated during HBV replication and poor prognosis HBV-related hepatocellular carcinoma (HCC). The objective of this study is to investigate the role of DDX5 in interferon (IFN) signalling. We provide ev…
View article: Clinical characteristics of the first known cases of death caused by COVID-19 pneumonia
Clinical characteristics of the first known cases of death caused by COVID-19 pneumonia Open
Severe pneumonia caused by COVID-19 has resulted in many deaths worldwide. Here, we analyzed the clinical characteristics of the first 17 reported cases of death due to COVID-19 pneumonia in Wuhan, China. Demographics, initial symptoms, co…
View article: RNA helicase DDX5 enables STAT1 mRNA translation and interferon signaling in hepatitis B virus replicating hepatocytes
RNA helicase DDX5 enables STAT1 mRNA translation and interferon signaling in hepatitis B virus replicating hepatocytes Open
Objective RNA helicase DDX5 is downregulated during hepatitis B virus (HBV) replication, and poor prognosis HBV-related hepatocellular carcinoma (HCC). The objective of this study is to understand the significance of DDX5 downregulation du…
View article: Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity
Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity Open
G-quadruplexes (G4) are considered new drug targets for human diseases such as cancer. More than 10,000 G4s have been discovered in human chromatin, posing challenges for assessing the selectivity of a G4-interactive ligand. 3,6-bis(1-Meth…
View article: Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes
Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes Open
Single-stranded DNA (ssDNA) containing four guanine repeats can form G-quadruplex (G4) structures. While cellular proteins and small molecules can bind G4s, it has been difficult to broadly assess their DNA-binding specificity. Here, we us…
View article: PDGFR-β Promoter Forms a Vacancy G-Quadruplex that Can Be Filled in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs
PDGFR-β Promoter Forms a Vacancy G-Quadruplex that Can Be Filled in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs Open
Aberrant expression of PDGFR-β is associated with a number of diseases. The G-quadruplexes (G4s) formed in PDGFR-β gene promoter are transcriptional modulators and amenable to small molecule targeting. The major G4 formed in the PDGFR-β ge…
View article: Protein and Ligand Interactions of <i>MYC</i> Promoter G-quadruplex
Protein and Ligand Interactions of <i>MYC</i> Promoter G-quadruplex Open
G-quadruplexes (G4s) are non-canonical secondary structures formed in single-stranded guanine-rich nucleic acid sequences, such as those found in oncogene promoters and telomeres. MYC, one of the most critical oncogenes, has a DNA G…
View article: Long-noncoding RNA Peg13 alleviates epilepsy progression in mice via the miR-490-3p/Psmd11 axis to inactivate the Wnt/β-catenin pathway.
Long-noncoding RNA Peg13 alleviates epilepsy progression in mice via the miR-490-3p/Psmd11 axis to inactivate the Wnt/β-catenin pathway. Open
Epilepsy, one of the most common neurological diseases with spontaneous recurrent seizures, is a severe health problem globally. The present study aimed to study the role and upstream mechanism of 26S proteasome non-ATPase regulatory subun…
View article: Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition
Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition Open
BMVC is the first fluorescent probe designed to detect G-quadruplexes (G4s) in vivo. The MYC oncogene promoter forms a G4 (MycG4) which acts as a transcription silencer. Here, we report the high-affinity and specific binding of BMVC to Myc…
View article: DDX5 helicase resolves G-quadruplex and is involved in <i>MYC</i> gene transcriptional activation
DDX5 helicase resolves G-quadruplex and is involved in <i>MYC</i> gene transcriptional activation Open
Significance G-quadruplexes (G4) are 4-stranded nucleic acid secondary structures. MYC is a critical oncogene with a G4 in its promoter (MycG4), which acts as a transcription silencer. MycG4 is very stable and the pathological activation o…
View article: Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the <i>MYC</i> Promoter G-Quadruplex and Downregulate <i>MYC</i>
Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the <i>MYC</i> Promoter G-Quadruplex and Downregulate <i>MYC</i> Open
MYC is one of the most important oncogenes and is overexpressed in the majority of cancers. G-Quadruplexes are noncanonical four-stranded DNA secondary structures that have emerged as attractive cancer-specific molecular targets for…
View article: Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres
Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres Open
G-quadruplex (G4) DNA secondary structures formed in human telomeres have been shown to inhibit cancer-specific telomerase and alternative lengthening of telomere (ALT) pathways. Thus, human telomeric G-quadruplexes are considered attracti…
View article: NMR structure of the 1:1 complex of a carbazole derivative BMVC bound to c-MYC G-quadruplex
NMR structure of the 1:1 complex of a carbazole derivative BMVC bound to c-MYC G-quadruplex Open
View article: Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes
Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes Open
View article: A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription
A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription Open
The abnormal overexpression of the BCL2 gene is associated with many human tumors. We found a new 28-mer G-quadruplex-forming sequence, P1G4, immediately upstream of the human BCL2 gene P1 promoter. The P1G4 is shown to be a transcription …