Explanipedia

Co-targeting menin and LSD1 dismantles oncogenic programs and restores differentiation in MLL-rearranged AML Open

Mina M. Tayari, Helena G. Dos Santos, Felipe Beckedorff, Tulasigeri M. Totiger, Adnan K. Mookhtiar , et al. · 2025

Acute myeloid leukemia (AML) harboring MLL ( MLL1, KMT2A ) rearrangement ( MLL-r ) remains a lethal subtype with limited durable responses to single-agent menin inhibition. To define rational combination strategies, we performed a high-thr…

Transposable Elements and Homotypic Niches Drive Immune Dynamics and Resistance in Melanoma Epigenetic-based immunotherapy Open

Erika Ciervo, Francesco Ceccarelli, Anna Maria Di Giacomo, Piera Grisolia, Alessia Covre , et al. · 2025

Melanoma plasticity drives immune evasion and therapy resistance through dynamic cell-state transitions beyond genetic alterations. Epigenetic remodeling critically influences such processes, yet its role in reshaping the tumor ecosystem u…

Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity Open

Hidehiro Itonaga, Adnan K. Mookhtiar, Sarah Greenblatt, Fan Liu, Concepción Martínez , et al. · 2024

697 Pulsed Electric Fields induces a stepwise activation of host anti-tumor immunity in patients with early-stage non-small cell lung cancer (NSCLC) Open

Marcelo F. Jiménez, José Fernández García-Hierro, Javier Flandes Aldeyturriaga, Erik H.F.M. van der Heijden, Calvin S.H. Ng , et al. · 2023

Background Enhancing anti-tumor immunity is a foundational therapeutic strategy against cancer.¹ The Aliya Pulsed Electric Fields (PEF) proprietary system has been shown to promote local and systemic anti-tumor immune activation…

Using a chat-based informed consent tool in large-scale genomic research Open

Sarah Savage, Jonathan LoTempio, Erica D. Smith, E. Hallie Andrew, Glòria Mas Martín , et al. · 2023

Objective We implemented a chatbot consent tool to shift the time burden from study staff in support of a national genomics research study. Materials and Methods We created an Institutional Review Board-approved script for automated chat-b…

The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression Open

Glòria Mas Martín, Na Man, Yuichiro Nakata, Concepcion Martinez-Caja, Daniel Karl , et al. · 2023

During emergency hematopoiesis, hematopoietic stem cells (HSCs) rapidly proliferate to produce myeloid and lymphoid effector cells, a response that is critical against infection or tissue injury. If unresolved, this process leads to sustai…

Increased diagnostic yield from negative whole genome‐slice panels using automated reanalysis Open

Seth Berger, Georgia Pitsava, Andrea J. Cohen, Emmanuèle C. Délot, Jonathan LoTempio , et al. · 2023

We evaluated the diagnostic yield using genome‐slice panel reanalysis in the clinical setting using an automated phenotype/gene ranking system. We analyzed whole genome sequencing (WGS) data produced from clinically ordered panels built as…

Data from ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia Open

Li Zhu, Qin Li, Stephen H.K. Wong, Min Huang, Brianna J. Klein , et al. · 2023

Numerous studies in multiple systems support that histone H3 lysine 36 dimethylation (H3K36me2) is associated with transcriptional activation; however, the underlying mechanisms are not well defined. Here, we show that the H3K36me2 chromat…

Supplementary Figures 1 - 5 from ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia Open

Zhu Li, Qin Li, Stephen H.K. Wong, Min Huang, Brianna J. Klein , et al. · 2023

Supplementary Figure 1 shows NMR and biochemical data in support of LEDGF nucleosome binding specificity. Supplementary Figure 2 shows chromatin IP data indicating requirement for LEDGF in MLL target gene localization. Supplementary Figure…

Supplementary Figures 1 - 5 from ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia Open

Zhu Li, Qin Li, Stephen H.K. Wong, Min Huang, Brianna J. Klein , et al. · 2023

Supplementary Figure 1 shows NMR and biochemical data in support of LEDGF nucleosome binding specificity. Supplementary Figure 2 shows chromatin IP data indicating requirement for LEDGF in MLL target gene localization. Supplementary Figure…

Data from ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia Open

Li Zhu, Li Qin, Stephen H.K. Wong, Min Huang, Brianna J. Klein , et al. · 2023

Numerous studies in multiple systems support that histone H3 lysine 36 dimethylation (H3K36me2) is associated with transcriptional activation; however, the underlying mechanisms are not well defined. Here, we show that the H3K36me2 chromat…

“Development and Implementation of Novel Chatbot-based Genomic Research Consent” Open

Erica D. Smith, Sarah Savage, E. Hallie Andrew, Glòria Mas Martín, Amanda Kahn-Kirby , et al. · 2023

Objective To conduct a retrospective analysis comparing traditional human-based consenting to an automated chat-based consenting process. Materials and Methods We developed a new chat-based consent using our IRB-approved consent forms. We …

Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity Open

Hidehiro Itonaga, Adnan K. Mookhtiar, Sarah Greenblatt, Fan Liu, Concepción Martínez , et al. · 2022

Coactivator-associated arginine methyltransferase 1 (CARM1) is overexpressed in cancer, and it has emerged as an important target in acute myeloid leukemia and other hematologic malignancies. Janus kinase 2 (JAK2), that is activated by mut…

Epigenetic and Transcriptional Regulation of Innate Immunity in Cancer. Open

Chuan Chen, Na Man, Glòria Mas Martín, Hidehiro Itonaga, Jun Sun , et al. · 2022

Innate immune cells participate in the detection of tumor cells via complex signaling pathways mediated by pattern-recognition receptors, such as Toll-like receptors and nucleotide-binding and oligomerization domain-like receptors. These p…

In vivo temporal resolution of acute promyelocytic leukemia progression reveals a role of <i>Klf4</i> in suppressing early leukemic transformation Open

Glòria Mas Martín, Fabio Santoro, Enrique Blanco, Gianni Paolo Gamarra Figueroa, François Le Dily , et al. · 2022

Genome organization plays a pivotal role in transcription, but how transcription factors (TFs) rewire the structure of the genome to initiate and maintain the programs that lead to oncogenic transformation remains poorly understood. Acute …

Epigenetic and Transcriptional Regulation of Innate Immunity in Cancer Open

Chuan Chen, Na Man, Fan Liu, Glòria Mas Martín, Hidehiro Itonaga , et al. · 2022

Innate immune cells participate in the detection of tumor cells via complex signaling pathways mediated by pattern-recognition receptors, such as Toll-like receptors and nucleotide-binding and oligomerization domain–like receptors. These p…

p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia Open

Na Man, Glòria Mas Martín, Daniel Karl, Jun Sun, Fan Liu , et al. · 2021

Myelodysplastic syndromes (MDS) are hematopoietic stem and progenitor cell (HSPC) malignancies characterized by ineffective hematopoiesis and an increased risk of leukemia transformation. Epigenetic regulators are recurrently mutated in MD…

Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures Open

Raquel García-Pérez, Paula Esteller-Cucala, Glòria Mas Martín, Irene Lobón, Valerio Di Carlo , et al. · 2021

Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates Open

David Juan, Raquel García-Pérez, Paula Esteller-Cucala, Glòria Mas Martín, Irene Lobón , et al. · 2021

Trabajo presentado en el VII Congress of the Spanish Society for Evolutionary Biology / VII Congreso de la Sociedad Española de Biología Evolutiva (SESBE VII), celebrado en Sevilla del 5 al 7 de febrero de 2020.

Epigenomic profiling of primate LCLs reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures Open

Raquel García-Pérez, Paula Esteller-Cucala, Glòria Mas Martín, Irene Lobón, Valerio Di Carlo , et al. · 2019

Summary To gain insight into the evolution of the epigenetic regulation of gene expression in primates, we extensively profiled a new panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ChIP-…

TAF1 plays a critical role in AML1-ETO driven leukemogenesis Open

Ye Xu, Na Man, Daniel Karl, Concepción Martínez, Fan Liu , et al. · 2019

Faculty Opinions recommendation of U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies. Open

Stephen D. Nimer, Glòria Mas Martín · 2019

Spliceosome mutations are common in MDS and AML, yet the oncogenic changes due to these mutations have not been identified.A global analysis of exon usage in AML samples revealed distinct molecular subsets containing alternative spliced is…

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification Open

Deqing Hu, Xin Gao, Kaixiang Cao, Marc A. Morgan, Glòria Mas Martín , et al. · 2017

ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia Open

Li Zhu, Qin Li, Stephen H.K. Wong, Min Huang, Brianna J. Klein , et al. · 2016

Numerous studies in multiple systems support that histone H3 lysine 36 dimethylation (H3K36me2) is associated with transcriptional activation; however, the underlying mechanisms are not well defined. Here, we show that the H3K36me2 chromat…

Barcelona conference on epigenetics and cancer 2015: Coding and non-coding functions of the genome Open

David Corujo, Glòria Mas Martín, Roberto Malinverni, Luciano Di Croce, Marcus Buschbeck · 2016

The Barcelona Conference on Epigenetics and Cancer (BCEC) entitled "Coding and Non-Coding functions of the Genome" took place October 29-30, 2015 in Barcelona. The 2015 BCEC was the third edition of a series of annual conferences jointly o…

Regulation of gene transcription by Polycomb proteins Open

Sergi Aranda, Glòria Mas Martín, Luciano Di Croce · 2015

New findings extend the functionality of mammalian Polycomb protein complexes on gene regulation and 3D chromatin conformation.

Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response Open

Erin K. Shanle, Forest H. Andrews, Hashem A. Meriesh, Stephen L. McDaniel, Raghuvar Dronamraju , et al. · 2015

The YEATS domain, found in a number of chromatin-associated proteins, has recently been shown to have the capacity to bind histone lysine acetylation. Here, we show that the YEATS domain of Taf14, a member of key transcriptional and chroma…

H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes Open

Mariona Nadal‐Ribelles, Glòria Mas Martín, Gonzalo Millán-Zambrano, Carme Solé, Gustav Ammerer , et al. · 2015

Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC chromatin remodelin…

Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response Open

Erin K. Shanle, Forest H. Andrews, Hashem A. Meriesh, Stephen L. McDaniel, Raghuvar Dronamraju , et al. · 2015

The YEATS domain, found in a number of chromatin-associated proteins, has recently been shown to have the capacity to bind histone lysine acetylation. Here, we show that the YEATS domain of Taf14, a member of key transcriptional and chroma…

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