Glyn Dawson
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Cover image caption: Mapping of serine phosphorylation sites in the 3D-modelled structure of FtsZ of Deinococcus radiodurans.The FtsZ of D. radiodurans (drFtsZ) undergoes phosphorylation by a DNA damage responsive Ser/Thr quinoprotein kina…
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Catalytic Enantioselective Synthesis of Silicon-Stereogenic Alkoxysilanes and Siloxanes novel Si-stereogenic siloxanes up to 99% ee ambient conditions atom economy [Rh(cod)Cl] 2 (1 mol%) + Si H H Si H O Josiphos (2.2 mol%) broad scope read…
View article: Connecting Exosomes and Connexins
Connecting Exosomes and Connexins Open
Intercellular communication is accomplished by passage of ions and small molecules through gap junction channels in directly contacting cells or by secretion and response to transmitters, hormones and extracellular vesicles in cells that a…
View article: Global Brain Transcriptome Analysis of a <i>Tpp1</i> Neuronal Ceroid Lipofuscinoses Mouse Model
Global Brain Transcriptome Analysis of a <i>Tpp1</i> Neuronal Ceroid Lipofuscinoses Mouse Model Open
In humans, homozygous mutations in the TPP1 gene results in loss of tripeptidyl peptidase 1 (TPP1) enzymatic activity, leading to late infantile neuronal ceroid lipofuscinoses disease. Using a mouse model that targets the Tpp1 gene and rec…
View article: Quantum dots and potential therapy for <scp>K</scp>rabbe's disease
Quantum dots and potential therapy for <span>K</span>rabbe's disease Open
Enzyme replacement therapy and substrate reduction therapy have proved useful in reversing many pathological consequences of many nonneural lysosomal storage diseases but have not yet reversed pathology or influenced disease outcome in Kra…
View article: Quantum dot‐mediated delivery of siRNA to inhibit sphingomyelinase activities in brain‐derived cells
Quantum dot‐mediated delivery of siRNA to inhibit sphingomyelinase activities in brain‐derived cells Open
The use of RNA i to suppress protein synthesis offers a potential way of reducing the level of enzymes or the synthesis of mutant toxic proteins but there are few tools currently available for their delivery. To address this problem, bioco…