Glynis L. Kolling
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View article: Metabolic network analysis of Crohn’s disease reveals sex- and age-specific cellular phenotypes
Metabolic network analysis of Crohn’s disease reveals sex- and age-specific cellular phenotypes Open
View article: Characterizing spatiotemporal expansion of Pseudomonas aeruginosa communities in polymer and mucin gel environments
Characterizing spatiotemporal expansion of Pseudomonas aeruginosa communities in polymer and mucin gel environments Open
View article: A systems biology approach to evaluate potential probiotic candidates for women’s vaginal health
A systems biology approach to evaluate potential probiotic candidates for women’s vaginal health Open
Probiotic supplements are marketed for diverse health benefits, yet species inclusion often lacks functional rationale. We surveyed 352 U.S. probiotic products and found 36 unique microbial species, with most supplements containing only on…
View article: Modeling spatiotemporal expansion of Pseudomonas aeruginosa communities within mucin gel mimetic environments
Modeling spatiotemporal expansion of Pseudomonas aeruginosa communities within mucin gel mimetic environments Open
View article: Metabolic Network Analysis of Crohn's Disease Reveals Sex- and Age-Specific Cellular Phenotypes
Metabolic Network Analysis of Crohn's Disease Reveals Sex- and Age-Specific Cellular Phenotypes Open
View article: Applying a polysaccharide lyase from <i>Stenotrophomonas maltophilia</i> to disrupt alginate exopolysaccharide produced by <i>Pseudomonas aeruginosa</i> clinical isolates
Applying a polysaccharide lyase from <i>Stenotrophomonas maltophilia</i> to disrupt alginate exopolysaccharide produced by <i>Pseudomonas aeruginosa</i> clinical isolates Open
Pseudomonas aeruginosa is considered one of the most challenging, drug-resistant, opportunistic pathogens partly due to its ability to synthesize robust biofilms. Biofilm is a mixture of extracellular polymeric substances (EPS) that encaps…
View article: Model-driven characterization of functional diversity of<i>Pseudomonas aeruginosa</i>clinical isolates with broadly representative phenotypes
Model-driven characterization of functional diversity of<i>Pseudomonas aeruginosa</i>clinical isolates with broadly representative phenotypes Open
Pseudomonas aeruginosa is a leading cause of infections in immunocompromised individuals and in healthcare settings. This study aims to understand the relationships between phenotypic diversity and the functional metabolic landscape of P. …
View article: Systems-ecology designed bacterial consortium protects from severe<i>Clostridioides difficile</i>infection
Systems-ecology designed bacterial consortium protects from severe<i>Clostridioides difficile</i>infection Open
Fecal Microbiota Transplant (FMT) is an emerging therapy that has had remarkable success in treatment and prevention of recurrent Clostridioides difficile infection (rCDI). FMT has recently been associated with adverse outcomes such as ina…
View article: Identifying metabolic adaptations during cardiotoxicity using paired transcriptomics and metabolomics data integrated with a model of heart metabolism
Identifying metabolic adaptations during cardiotoxicity using paired transcriptomics and metabolomics data integrated with a model of heart metabolism Open
Improvements in the diagnosis and treatment of cancer has revealed the long-term side effects of chemotherapeutics, particularly cardiotoxicity. Here, we present paired transcriptomics and metabolomics data characterizing in vitro cardioto…
View article: S100B Inhibition Attenuates Intestinal Damage and Diarrhea Severity During Clostridioides difficile Infection by Modulating Inflammatory Response
S100B Inhibition Attenuates Intestinal Damage and Diarrhea Severity During Clostridioides difficile Infection by Modulating Inflammatory Response Open
The involvement of the enteric nervous system, which is a source of S100B, in Clostridioides difficile ( C. difficile ) infection (CDI) is poorly understood although intestinal motility dysfunctions are known to occur following infection. …
View article: Identifying functional metabolic shifts in heart failure with the integration of omics data and a heart-specific, genome-scale model
Identifying functional metabolic shifts in heart failure with the integration of omics data and a heart-specific, genome-scale model Open
In diseased states, the heart can shift to use different carbon substrates, measured through changes in uptake of metabolites by imaging methods or blood metabolomics. However, it is not known whether these measured changes are a result of…
View article: Identifying functional metabolic shifts in heart failure with the integration of omics data and a cardiomyocyte-specific, genome-scale model
Identifying functional metabolic shifts in heart failure with the integration of omics data and a cardiomyocyte-specific, genome-scale model Open
Summary The heart is a metabolic omnivore, known to consume many different carbon substrates in order to maintain function. In diseased states, the heart’s metabolism can shift between different carbon substrates; however, there is some di…
View article: Minimum bactericidal concentration of ciprofloxacin to Pseudomonas aeruginosa determined rapidly based on pyocyanin secretion
Minimum bactericidal concentration of ciprofloxacin to Pseudomonas aeruginosa determined rapidly based on pyocyanin secretion Open
View article: Genome-Scale Characterization of Toxicity-Induced Metabolic Alterations in Primary Hepatocytes
Genome-Scale Characterization of Toxicity-Induced Metabolic Alterations in Primary Hepatocytes Open
Context-specific GEnome-scale metabolic Network REconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically-exposed rat hepatocytes…
View article: Functional Anabolic Network Analysis of Human-associated<i>Lactobacillus</i>Strains
Functional Anabolic Network Analysis of Human-associated<i>Lactobacillus</i>Strains Open
Members of the Lactobacillus genus are frequently utilized in the probiotic industry with many species conferring demonstrated health benefits; however, these effects are largely strain-dependent. We designed a method called PROTEAN (Proba…
View article: A novel mouse model of<i>Campylobacter jejuni</i>enteropathy and diarrhea
A novel mouse model of<i>Campylobacter jejuni</i>enteropathy and diarrhea Open
Campylobacter infections are among the leading bacterial causes of diarrhea and of ‘environmental enteropathy’ (EE) and growth failure worldwide. However, the lack of an inexpensive small animal model of enteric disease with Campylobacter …
View article: Metabolic mechanisms of interaction within a defined gut microbiota
Metabolic mechanisms of interaction within a defined gut microbiota Open
Metabolic interactions among species are ubiquitous in nature, and the fitness costs and benefits they impose often reinforce and stabilize them over time. These interactions are of particular importance in the human gut, where they have f…
View article: Novel co-culture plate enables growth dynamic-based assessment of contact-independent microbial interactions
Novel co-culture plate enables growth dynamic-based assessment of contact-independent microbial interactions Open
Interactions between microbes are central to the dynamics of microbial communities. Understanding these interactions is essential for the characterization of communities, yet challenging to accomplish in practice. There are limited availab…
View article: Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions
Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions Open
The laboratory rat has been used as a surrogate to study human biology for more than a century. Here we present the first genome-scale network reconstruction of Rattus norvegicus metabolism, iRno , and a significantly improved reconstructi…
View article: Cross-modulation of pathogen-specific pathways enhances malnutrition during enteric co-infection with Giardia lamblia and enteroaggregative Escherichia coli
Cross-modulation of pathogen-specific pathways enhances malnutrition during enteric co-infection with Giardia lamblia and enteroaggregative Escherichia coli Open
Diverse enteropathogen exposures associate with childhood malnutrition. To elucidate mechanistic pathways whereby enteric microbes interact during malnutrition, we used protein deficiency in mice to develop a new model of co-enteropathogen…
View article: Systems-level metabolism of the altered Schaedler flora, a complete gut microbiota
Systems-level metabolism of the altered Schaedler flora, a complete gut microbiota Open
The altered Schaedler flora (ASF) is a model microbial community with both in vivo and in vitro relevance. Here we provide the first characterization of the ASF community in vitro, independent of a murine host. We compared the functional g…
View article: Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype
Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype Open
View article: Early-life enteric infections: relation between chronic systemic inflammation and poor cognition in children
Early-life enteric infections: relation between chronic systemic inflammation and poor cognition in children Open
The intestinal microbiota undergoes active remodeling in the first 6 to 18 months of life, during which time the characteristics of the adult microbiota are developed. This process is strongly influenced by the early diet and enteric patho…
View article: Vancomycin Treatment Alters Humoral Immunity and Intestinal Microbiota in an Aged Mouse Model of<i>Clostridium difficile</i>Infection
Vancomycin Treatment Alters Humoral Immunity and Intestinal Microbiota in an Aged Mouse Model of<i>Clostridium difficile</i>Infection Open
Vancomycin treatment decreases the systemic humoral response to CDI. Increased mortality from and recurrence of CDI in the aged host are associated with an impaired humoral response and a greater susceptibility to vancomycin-induced altera…
View article: Treatment of<i>Clostridium difficile</i>infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model
Treatment of<i>Clostridium difficile</i>infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model Open
SQ641 is effective for CDI treatment with prevention of relapse in the murine model of CDI.
View article: Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model
Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model Open
Cryptosporidium is a major cause of severe diarrhea, especially in malnourished children. Using a murine model of C. parvum oocyst challenge that recapitulates clinical features of severe cryptosporidiosis during malnutrition, we interroga…
View article: Correction: Defined Nutrient Diets Alter Susceptibility to Clostridium difficile Associated Disease in a Murine Model
Correction: Defined Nutrient Diets Alter Susceptibility to Clostridium difficile Associated Disease in a Murine Model Open
View article: Defined Nutrient Diets Alter Susceptibility to Clostridium difficile Associated Disease in a Murine Model
Defined Nutrient Diets Alter Susceptibility to Clostridium difficile Associated Disease in a Murine Model Open
Low protein diets, and defined nutrient diets in general, were found to be protective against CDI in mice. Associated diet-induced alterations in intestinal microbiota may influence colonization resistance and clostridial toxin production …
View article: Natural killer T (NKT) cells accelerate Shiga toxin type 2 (Stx2) pathology in mice
Natural killer T (NKT) cells accelerate Shiga toxin type 2 (Stx2) pathology in mice Open
Shiga toxin-producing Escherichia coli (STEC) is a leading cause of childhood renal disease Hemolytic Uremic Syndrome (HUS). The involvement of renal cytokines and chemokines is suspected to play a critical role in disease progression. In …
View article: Poor Disease Outcome From Clostridium difficile Infection in the Aged Host: Role of Impaired Innate Immunity and Altered Intestinal Microbiota in a Mouse Model
Poor Disease Outcome From Clostridium difficile Infection in the Aged Host: Role of Impaired Innate Immunity and Altered Intestinal Microbiota in a Mouse Model Open