Explanipedia

Patterns of Extrathoracic Metastasis in Lung Cancer Patients Open

Hyung Kyu Park, Joungho Han, Ghee Young Kwon, Min‐Kyung Yeo, Go Eun Bae · 2022

Metastasis is a major cause of death in lung cancer patients. Therefore, a deeper understanding of the metastatic mechanisms is important for developing better management strategies for lung cancer patients. This study evaluated the patter…

Cytopathologic features of human papillomavirus–independent, gastric-type endocervical adenocarcinoma Open

Min‐Kyung Yeo, Go Eun Bae, Dong-Hyun Kim, In-Ock Seong, Kwang‐Sun Suh · 2022

Background: Gastric-type endocervical adenocarcinoma (GEA) is unrelated to human papillomavirus (HPV) infection and is clinically aggressive compared with HPV-associated usual-type endocervical adenocarcinoma (UEA). The cytological diagnos…

Cosuppression of NF-κB and AICDA Overcomes Acquired EGFR-TKI Resistance in Non-Small Cell Lung Cancer Open

Min‐Kyung Yeo, Yoonjoo Kim, Da Hye Lee, Chaeuk Chung, Go Eun Bae · 2022

Background: Acquired resistance after EGFR-tyrosine kinase inhibitor (TKI) treatment is the rule rather than the exception. Overcoming resistance to EGFR-TKIs is essential if we are to develop better therapeutic strategies for lung cancer …

Characterization of Poorly Cohesive and Signet Ring Cell Carcinomas and Identification of PTPRM as a Diagnostic Marker Open

Go Eun Bae, Sun Hyung Kang, Ju Kim, Seok‐Hwan Kim, Kyung‐Hee Kim , et al. · 2022

Background and aims. Signet ring cell (SRC) and poorly cohesive (PC) gastric carcinomas are morphologically similar but exhibit different biological behavior. We compared the clinical and molecular characteristics of SRC and PC carcinomas.…

Multi-Scale Hybrid Vision Transformer for Learning Gastric Histology: AI-Based Decision Support System for Gastric Cancer Treatment Open

Yujin Oh, Go Eun Bae, Kyung‐Hee Kim, Min‐Kyung Yeo, Jong Chul Ye · 2022

Gastric endoscopic screening is an effective way to decide appropriate gastric cancer (GC) treatment at an early stage, reducing GC-associated mortality rate. Although artificial intelligence (AI) has brought a great promise to assist path…

Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Immunohistochemical Analyses Using Markers for Mesonephric, Endometrioid and Serous Tumors Open

Hyunjin Kim, Kiyong Na, Go Eun Bae, Hyun Soo Kim · 2021

Mesonephric-like adenocarcinoma (MLA) of the uterine corpus is a rare but distinct malignant tumor of the female genital tract, demonstrating a characteristic morphology and unique immunohistochemical profiles and molecular alterations. We…

Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis Open

Sohyun Eun, Haemin Kim, Ha Yan Kim, Myeongjee Lee, Go Eun Bae , et al. · 2021

Mesonephric-like Differentiation of Endometrial Endometrioid Carcinoma: Clinicopathological and Molecular Characteristics Distinct from Those of Uterine Mesonephric-like Adenocarcinoma Open

Sujin Park, Go Eun Bae, Ji-Young Kim, Hyun Soo Kim · 2021

When diagnosing endometrial carcinoma cases, we encountered histological features that strikingly resembled uterine mesonephric-like adenocarcinoma (MLA), but the differential diagnosis remained challenging after performing immunostaining.…

Clinicopathologic and Molecular Characteristics of Gastrointestinal MiNENs Open

Min‐Kyung Yeo, Nara Yoon, Go Eun Bae · 2021

Background A mixed neuroendocrine–non-neuroendocrine neoplasm (MiNEN) is a recently defined entity that comprises a neuroendocrine tumor (NEN) component and a non-neuroendocrine tumor (nNEN) component. As MiNEN is a recently defined entity…

Targeted Sequencing of Ascites and Peritoneal Washing Fluid of Patients With Gastrointestinal Cancers and Their Clinical Applications and Limitations Open

Go Eun Bae, Seok‐Hwan Kim, Min Kyung Choi, Jin‐Man Kim, Min‐Kyung Yeo · 2021

Cytology from gastrointestinal (GI) cancers is frequently obtained from ascites and peritoneal washing fluids. Examination of ascites and peritoneal washing fluids from patients with GI cancers can help in the tumor staging and prognosis. …

Subepithelial spread of early gastric cancer is common and extends more than expected Open

Min‐Kyung Yeo, Sun Hyung Kang, Hyuk Soo Eun, Eaum Seok Lee, Hee Seok Moon , et al. · 2021

Serum-Based KRASG12/G13 Mutation Detection Using Droplet Digital PCR: Clinical Implications and Limitations in Colorectal Adenocarcinoma With Tumor Heterogeneity Open

Ju Kim, Go Eun Bae, Seok‐Hwan Kim, Min Kyung Choi, Min‐Kyung Yeo · 2021

Background Cell-free DNA (cfDNA) has arisen as an alternative target for evaluating somatic mutations in cancer. KRAS mutation status is critical for targeted therapy in colorectal adenocarcinoma (CRAC). We evaluated KRAS G12/G13 mutations…

Ovarian Mesonephric-like Adenocarcinoma With Multifocal Microscopic Involvement of the Fimbrial Surface: Potential for Misdiagnosis of Tubal Intraepithelial Metastasis as Serous Tubal Intraepithelial Carcinoma Associated With Ovarian High-grade Serous Carcinoma Open

Hyunjin Kim, Go Eun Bae, Yoon Yang Jung, Hyun Soo Kim · 2021

Microscopic intraepithelial metastases of the MLA to the fimbria mimic STIC. We recommend ancillary tests, such as immunostaining, in patients with ovarian tumors whenever possible, particularly for those with differential diagnosis of MLA…

Identification of a Clinical Cutoff Value for Multiplex KRASG12/G13 Mutation Detection in Colorectal Adenocarcinoma Patients Using Digital Droplet PCR, and Comparison with Sanger Sequencing and PNA Clamping Assay Open

Kyung Ha Lee, Tae Hee Lee, Min Kyung Choi, In Sun Kwon, Go Eun Bae , et al. · 2020

KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) is a major predictive marker for anti-epidermal growth factor receptor treatment, and determination of KRAS mutational status is crucial for successful management of colorectal adenocarci…

Clinical Significance of Tumor and Immune Cell PD-L1 Expression in Gastric Adenocarcinoma Open

Dong Hyun Kim, Go Eun Bae, Kwang Sun Suh, DAVID RYUMAN, Kyu Sang Song , et al. · 2020

PD-L1 protein expression in TCs and ICs can be used as a prognostic indicator for GC patients, particularly in the EBV^-, MSI, and MSS subgroups.

Clinicopathological Characteristics of Squamous Cell Carcinoma and High-grade Squamous Intraepithelial Lesions Involving Endocervical Polyps Open

Cheol Keun Park, Yong Wook Kim, Hyun Hee Koh, Nara Yoon, Go Eun Bae , et al. · 2020

The prevalence of HSIL and SCC involving ECP in our cohort was similar to the rates found in previous studies. The presence of residual HSIL in nonpolypoid cervical tissue regardless of the polypectomy margin involvement suggests that coni…

Comparison of Benign and Malignant Pilomatricomas Using Whole-exome Sequencing Open

Min‐Kyung Yeo, Go Eun Bae · 2020

This study, the first comparative analysis of benign and MP through whole-exome analysis, identified a novel oncogenic mutation in FGFR4.

Clinicopathological and Molecular Differences Between Gastric-type Mucinous Carcinoma and Usual-type Endocervical Adenocarcinoma of the Uterine Cervix Open

Hera Jung, Go Eun Bae, Hye Min Kim, Hyun Soo Kim · 2020

GMC is associated with more aggressive behavior than UEA. Distinctive p53 and p16 immunostaining patterns enable differential diagnosis. GMC and UEA exhibit genetic heterogeneity with potentially actionable molecular alterations.

Prognostic Significance of LC3B and p62/SQSTM1 Expression in Gastric Adenocarcinoma Open

Ju Kim, Go Eun Bae, Kyung‐Hee Kim, Sang Il Lee, Chaeuk Chung , et al. · 2019

Autophagy is a cellular mechanism that recycles cellular components to maintain homeostasis. To investigate the clinical implication of autophagy in gastric cancer, the autophagy markers with autophagosome formation, LC3B and selective aut…

Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy Open

Kwang‐Sun Suh, Song‐Yi Choi, Go Eun Bae, Dae Eun Choi, Min‐Kyung Yeo · 2019

Anti-glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune complexes ha…

Increased Sphingosine Kinase 1 Expression Predicts Distant Metastasis and Poor Outcome in Patients With Colorectal Cancer Open

Go Eun Bae, Sung‐Im Do, Kyungeun Kim, Ji Hyun Park, SiHyun Cho , et al. · 2019

High SPHK1 expression was significantly associated with aggressive CRC behavior and worse overall survival, and was an independent predictor of distant metastasis. SPHK1 may thus be a potential prognostic biomarker and therapeutic target i…

Clinicopathological and Molecular Characteristics of Mammary Adenoid Cystic Carcinoma With Adipocytic Differentiation With Emphasis on the Identification of a Novel <i>BRAF</i> Mutation Open

Go Eun Bae, Nara Yoon, Eun Yoon Cho, Hyun Soo Kim, Soo Youn Cho · 2018

We report the first case, as far as we are aware, of primary mammary adenoid cystic carcinoma with adipocytic differentiation. A novel missense mutation in BRAF was detected. The potential response to BRAF inhibitors in the presence of thi…

Lower Sympathetic Nervous System Density and β-adrenoreceptor Expression Are Involved in Gastric Cancer Progression Open

Go Eun Bae, Hyun Soo Kim, Kyu Yeoun Won, Gou Young Kim, Ji‐Youn Sung , et al. · 2018

A lower SNS density and β-adrenoreceptor expression was associated with an aggressive oncogenic behavior including worse histological grade, advanced pT, and increased lymph node metastasis. SNS and β-adrenergic pathway are involved in the…

Effect of varying external pneumatic pressure on hemolysis and red blood cell elongation index in fresh and aged blood Open

Yoon Ji Choi, Hyub Huh, Go Eun Bae, Eunji Ko, Sung-Uk Choi , et al. · 2018

Irreversible changes in RBCs did not occur as a result of external pressure. The hemolysis and elongation indices of fresh RBCs were not influenced by external pneumatic pressure up to 300 mmHg. Only the storage period affected the irrever…

B-cell translocation gene 1 is downregulated by promoter methylation in ovarian carcinoma Open

Ji‐Ye Kim, Sung‐Im Do, Go Eun Bae, Hyun Soo Kim · 2017

A better understanding of tumor biology is important in the identification of molecules that are downregulated in malignancy and in determining their role in tumor suppression. B-cell translocation gene 1 (BTG1) has been shown to act as a …

High-grade squamous intraepithelial lesion arising adjacent to vulvar lymphangioma circumscriptum: a tertiary institutional experience Open

Go Eun Bae, Gun Yoon, Yong Jung Song, Hyun Soo Kim · 2016

Lymphangioma circumscriptum of the vulva occurs in patients who have undergone radical hysterectomy, lymph node dissection, or radiation therapy for management of advanced uterine cancer. Since vulvar lymphangioma circumscriptum typically …

Eosinophils in Colorectal Neoplasms Associated with Expression of CCL11 and CCL24 Open

Hyuck Cho, Sung‐Jig Lim, Kyu Yeoun Won, Go Eun Bae, Gou Young Kim , et al. · 2015

The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemoki…

Chronic Placental Inflammation in Twin Pregnancies Open

Heejin Bang, Go Eun Bae, Ha Young Park, Yeon Mee Kim, Suk‐Joo Choi , et al. · 2015

Background: Chronic placental inflammation, such as villitis of unknown etiology (VUE) and chronic chorioamnionitis (CCA), is considered a placental manifestation of maternal anti-fetal rejection. The aim of this study is to investigate it…

Exuberant squamous metaplasia of the gastric mucosa in a patient with gastric adenocarcinoma Open

Sangjeong Ahn, Go Eun Bae, Kyoung‐Mee Kim · 2015

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1035146445160150 .

Expression of tumoral FOXP3 in gastric adenocarcinoma is associated with favorable clinicopathological variables and related with Hippo pathway. Open

J. H. Suh, Kyu Yeoun Won, Gou Young Kim, Go Eun Bae, Sung‐Jig Lim , et al. · 2015

FOXP3 is a transcription factor and well-known hallmark of immune suppressive T regulatory cells (Tregs). Recent studies indicate that, in addition to its association with Treg function in the immune system, FOXP3 plays an important role i…

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