Explanipedia

Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser Open

Hoyoung Kim, Taehyun Lim, Go Eun Ha, Jee‐Young Lee, Jun‐Woo Kim , et al. · 2023

Thus far, attempts to develop drugs that target corticotropin-releasing hormone receptor 1 (CRF 1 R), a drug target in stress-related therapy, have been unsuccessful. Studies have focused on using high-resolution G protein-coupled receptor…

Intracellular Loop in the Brain Isoforms of Anoctamin 2 Channels Regulates Calcium-dependent Activation Open

Dongsu Lee, Hocheol Lim, Jungryun Lee, Go Eun Ha, Kyoung Tai No , et al. · 2023

Anoctamin 2 (ANO2 or TMEM16B), a calcium-activated chloride channel (CaCC), performs diverse roles in neurons throughout the central nervous system. In hippocampal neurons, ANO2 narrows action potential width and reduces postsynaptic depol…

Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake Open

Go Eun Ha, Eunji Cheong · 2021

Stress activates the hypothalamic-pituitary-adrenal system, and induces the release of glucocorticoids, stress hormones, into circulation. Many studies have shown that stress affects feeding behavior, however, the underlying circuitry and …

Author Correction: The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons Open

Go Eun Ha, Jaekwang Lee, Hankyul Kwak, Kiyeong Song, Jea Kwon , et al. · 2021

Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus Open

Hankyul Kwak, Wuhyun Koh, Sangwoo Kim, Kiyeong Song, Jeong-Im Shin , et al. · 2020

Destabilization of light NREM sleep by thalamic PLCβ4 deletion impairs sleep-dependent memory consolidation Open

Joohyeon Hong, Go Eun Ha, Hankyul Kwak, Yelin Lee, Hyeonyeong Jeong , et al. · 2020

Sleep abnormality often accompanies the impairment of cognitive function. Both rapid eye movement (REM) and non-REM (NREM) sleep have associated with improved memory performance. However, the role of composition in NREM sleep, consisting o…

Long-term Intracellular Recording of Optogenetically-induced Electrical Activities using Vertical Nanowire Multi Electrode Array Open

Ji-Soo Yoo, Hankyul Kwak, Juyoung Kwon, Go Eun Ha, Elliot H. Lee , et al. · 2020

Continuous recording of intracellular activities in single cells is required for deciphering rare, dynamic and heterogeneous cell responses, which are missed by population or brief single-cell recording. Even if the field of intracellular …

Synaptic modifications in the ventral hippocampal neurons in the learned helplessness model of depression Open

Sangwoo Kim, Gyeong-Eon Chang, Hyojung Lee, Dongsu Lee, Gyeong Hwuii Kim , et al. · 2019

Differential change of light and deep NREM sleep by thalamic PLCβ4 Open

Joohyeon Hong, Go Eun Ha, Hankyul Kwak, Yelin Lee, Hyeonyeong Jeong , et al. · 2019

The Possible Role of Neurobeachin in Extinction of Contextual Fear Memory Open

Boyoung Lee, Eunyoung Bang, Won Suk Yang, Afshin Paydar, Go Eun Ha , et al. · 2018

Spike Frequency Adaptation in Neurons of the Central Nervous System Open

Go Eun Ha, Eunji Cheong · 2017

Neuronal firing patterns and frequencies determine the nature of encoded information of the neurons. Here we discuss the molecular identity and cellular mechanisms of spike-frequency adaptation in central nervous system (CNS) neurons. Calc…

A conserved neuronal DAF-16/FoxO plays an important role in conveying pheromone signals to elicit repulsion behavior in Caenorhabditis elegans Open

Donha Park, Jeong-Hoon Hahm, Saeram Park, Go Eun Ha, Gyeong-Eon Chang , et al. · 2017

ZnO nanotube waveguide arrays on graphene films for local optical excitation on biological cells Open

Hyeonjun Baek, Hankyul Kwak, Minho Song, Go Eun Ha, Jongwoo Park , et al. · 2017

We report on scalable and position-controlled optical nanoprobe arrays using ZnO nanotube waveguides on graphene films for use in local optical excitation. For the waveguide fabrication, position-controlled and well-ordered ZnO nanotube ar…

Calcium-activated chloride channels: a new target to control the spiking pattern of neurons Open

Go Eun Ha, Eunji Cheong · 2017

The nature of encoded information in neural circuits is determined by neuronal firing patterns and frequencies. This paper discusses the molecular identity and cellular mechanisms of spike-frequency adaptation in the central nervous system…

The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons Open

Go Eun Ha, Jaekwang Lee, Hankyul Kwak, Kiyeong Song, Jea Kwon , et al. · 2016

The thalamic mGluR1-PLCβ4 pathway is critical in sleep architecture Open

Joohyeon Hong, Jungryun Lee, Kiyeong Song, Go Eun Ha, Yong Ryoul Yang , et al. · 2016

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