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Cost-effectiveness analysis of pembrolizumab in patients with treatment-refractory metastatic colorectal cancer in Japan Open

Kiyoaki Sugiura, Hiroki Hiratsuka, Go Oshima, Satoshi Aiko · 2023

Medicine Chemistry

Objective The immune checkpoint inhibitor pembrolizumab has recently been recognized as a standard treatment regimen for patients with metastatic colorectal cancer and the microsatellite-instability-high/mismatch repair-deficient mutation.…

Figure S8 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Chemistry

Cancer cells MCF7 with strong response to 5-Aza-dC have hypermethylated MEG3-DMR promoter

Figure S3 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Medicine

Failure of DNMT 1/3B double-knockout cells to produce liver metastases.

Figure S1-S2 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology

Plasmid map of CRISPR vector and deletion schematic for CFdel cells

Figure S7 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Chemistry

Colo320 cells have limited response to 5-Aza-dC treatment and fail to produce liver metastases in vivo

Figure S8 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Chemistry

Cancer cells MCF7 with strong response to 5-Aza-dC have hypermethylated MEG3-DMR promoter

Data from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Computer science

Expression of 14q32-encoded miRNAs is a favorable prognostic factor in patients with metastatic cancer. In this study, we used genomic inhibition of DNA methylation through disruption of DNA methyltransferases DNMT1 and DNMT3B and pharmaco…

Figure S3 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Medicine

Failure of DNMT 1/3B double-knockout cells to produce liver metastases.

Figure S4 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology

Viability of HCT116-L2T cells after treatment with 5-aza-dC

Tables S1-S4 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology

Supplementary Tables S1-S4 show primers and gRNAs used in CRISPR/cas9 experiments and differential expression of 14q32 microRNAs in DKO mice and after treatment by 5-Aza-dC.

Figure S7 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Medicine

Colo320 cells have limited response to 5-Aza-dC treatment and fail to produce liver metastases in vivo

Supplementary Figures S5-S6 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology

Supplemental Figures S5-S6. Distribution of CpG sites, transcription start site and methylation-dependent CTCF binding region in DLK1-MEG9 region.

Figure S1-S2 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Engineering

Plasmid map of CRISPR vector and deletion schematic for CFdel cells

Tables S1-S4 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology

Supplementary Tables S1-S4 show primers and gRNAs used in CRISPR/cas9 experiments and differential expression of 14q32 microRNAs in DKO mice and after treatment by 5-Aza-dC.

Data from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology

Expression of 14q32-encoded miRNAs is a favorable prognostic factor in patients with metastatic cancer. In this study, we used genomic inhibition of DNA methylation through disruption of DNA methyltransferases DNMT1 and DNMT3B and pharmaco…

Legends to Supplementary Tables and Figures from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology

Legends to Supplementary Tables S1-S4 and Supplementary Figures S1-S8

Figure S4 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Chemistry Medicine

Viability of HCT116-L2T cells after treatment with 5-aza-dC

Legends to Supplementary Tables and Figures from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology

Legends to Supplementary Tables S1-S4 and Supplementary Figures S1-S8

Supplementary Figures S5-S6 from DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs Open

Go Oshima, Elizabeth C. Poli, Michael J. Bolt, Alexandre Chlenski, Martin Forde , et al. · 2023

Biology Philosophy

Supplemental Figures S5-S6. Distribution of CpG sites, transcription start site and methylation-dependent CTCF binding region in DLK1-MEG9 region.

Gamma‐synuclein is a novel prognostic marker that promotes tumor cell migration in biliary tract carcinoma Open

Yusuke Takemura, Hidenori Ojima, Go Oshima, Masahiro Shinoda, Yasushi Hasegawa , et al. · 2021

Medicine Biology

Gamma‐synuclein (SNCG) promotes invasive behavior and is reportedly a prognostic factor in a range of cancers. However, its role in biliary tract carcinoma (BTC) remains unknown. Consequently, we investigated the clinicopathological signif…

Pancreaticoduodenectomy with Non-Reconstruction of the Remnant Pancreas in Patients with Fat Replacement of the Pancreatic Tail: A Report of Two Cases Open

Kodai Abe, Minoru Kitago, Yohei Masugi, Masahiro Shinoda, Hiroshi Yagi , et al. · 2021

Medicine

症例1は47歳の女性で,膵癌を疑う膵腫瘍に対し亜全胃温存膵頭十二指腸切除を施行した.膵尾部は脂肪置換され残膵断端の主膵管は同定できなかったため,膵管空腸吻合をせず膵断端を縫合し挙上空腸と膵実質を密着縫合した.術後に膵液漏は認めたが内分泌機能は良好で術後第33病日に退院した.術後2年5か月無再発で耐糖能良好である.症例2は46歳の男性で,慢性膵炎の既往がある膵神経内分泌腫瘍に対して亜全胃温存膵頭十二指腸切除を施行した.膵実質は脂肪置換され主膵管を同定できなかった.断端迅速組織…

O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer Open

Takahiro Yokose, Yasuaki Kabe, Atsushi Matsuda, Minoru Kitago, Sachiko Matsuda , et al. · 2020

Medicine Chemistry Biology

Pancreatic cancer (PC) is among the most lethal malignancies due to an often delayed and difficult initial diagnosis. Therefore, the development of a novel, early stage, diagnostic PC marker in liquid biopsies is of great significance. In …

A prospective feasibility study of one-year administration of adjuvant S-1 therapy for resected biliary tract cancer in a multi-institutional trial (Tokyo Study Group for Biliary Cancer: TOSBIC01) Open

Osamu Itano, Yusuke Takemura, Norihiro Kishida, Eiji Tamagawa, Hiroharu Shinozaki , et al. · 2020

Medicine

Background Although surgery is the definitive curative treatment for biliary tract cancer (BTC), outcomes after surgery alone have not been satisfactory. Adjuvant therapy with S-1 may improve survival in patients with BTC. This study exami…

Combination of <i>KRAS</i> and <i>SMAD4</i> mutations in formalin‐fixed paraffin‐embedded tissues as a biomarker for pancreatic cancer Open

Takahiro Yokose, Minoru Kitago, Sachiko Matsuda, Yasushi Sasaki, Yohei Masugi , et al. · 2020

Medicine Biology

Formalin‐fixed paraffin‐embedded (FFPE) tissues used for routine pathological diagnosis are valuable for cancer genomic analysis; however, the association between mutation status derived from these specimens and prognosis in pancreatic duc…

Usefulness of <sup>18</sup>F‐fluorodeoxyglucose positron emission tomography/computed tomography for predicting the prognosis and treatment response of neoadjuvant therapy for pancreatic ductal adenocarcinoma Open

Takahiro Yokose, Minoru Kitago, Yohji Matsusaka, Yohei Masugi, Masahiro Shinoda , et al. · 2020

Medicine

Background The Response Evaluation Criteria in Solid Tumors (RECIST) for computed tomography (CT) is preoperatively used to evaluate therapeutic effects. However, it does not reflect the pathological treatment response (PTR) of pancreatic …

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