Go Eun Yang
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View article: Efficacy and Safety of Biosimilar CT-P47 Versus Reference Tocilizumab: 1-Year Results of a Randomised, Active-Controlled, Double-Blind, Phase III Study in Patients with Rheumatoid Arthritis
Efficacy and Safety of Biosimilar CT-P47 Versus Reference Tocilizumab: 1-Year Results of a Randomised, Active-Controlled, Double-Blind, Phase III Study in Patients with Rheumatoid Arthritis Open
NCT05489224, 24 July 2022.
View article: Efficacy and safety of CT-P47 versus reference tocilizumab: 32-week results of a randomised, active-controlled, double-blind, phase III study in patients with rheumatoid arthritis, including 8 weeks of switching data from reference tocilizumab to CT-P47
Efficacy and safety of CT-P47 versus reference tocilizumab: 32-week results of a randomised, active-controlled, double-blind, phase III study in patients with rheumatoid arthritis, including 8 weeks of switching data from reference tocilizumab to CT-P47 Open
Objectives To demonstrate efficacy equivalence of CT-P47 and EU-approved reference tocilizumab (r-TCZ) in patients with rheumatoid arthritis (RA). Methods This double-blind, phase III study randomised (1:1) patients to receive CT-P47 or r-…
View article: Pharmacokinetics and safety of candidate tocilizumab biosimilar CT-P47 administered by auto-injector or pre-filled syringe: a randomized, open‑label, single-dose phase I study
Pharmacokinetics and safety of candidate tocilizumab biosimilar CT-P47 administered by auto-injector or pre-filled syringe: a randomized, open‑label, single-dose phase I study Open
ClinicalTrials.gov: NCT05617183.
View article: Rare Columnar Cell Variant of Papillary Thyroid Carcinoma with CervicalSpine Metastasis: A Case Report
Rare Columnar Cell Variant of Papillary Thyroid Carcinoma with CervicalSpine Metastasis: A Case Report Open
Background:: Columnar cell carcinoma is a rare subtype of papillary thyroid carcinoma (CCV-PTC) that accounts for only 0.15% to 0.2% of all Papillary Thyroid Carcinomas (PTCs). It has aggressive behavior but a better prognosis than anaplas…
View article: Immunoglobulin G4 (IgG4)-related Lymphadenopathy in Submandibular SpaceMimicking Submandibular Malignant Tumor: A Case Report
Immunoglobulin G4 (IgG4)-related Lymphadenopathy in Submandibular SpaceMimicking Submandibular Malignant Tumor: A Case Report Open
Background:: Immunoglobulin G4 (Ig G4)-related disease is rare; however, it is a fibroinflammatory disease that has been studied a lot so far. Although the expression pattern varies depending on the organ affected, it usually manifests as …
View article: Pharmacokinetics and safety of candidate tocilizumab biosimilar CT-P47 versus reference tocilizumab: a randomized, double-blind, single-dose phase I study
Pharmacokinetics and safety of candidate tocilizumab biosimilar CT-P47 versus reference tocilizumab: a randomized, double-blind, single-dose phase I study Open
www.clinicaltrials.gov identifier is NCT05188378.
View article: Case Reports of Intravascular Treatment for Gastrointestinal Bleeding Associated with Pancreatitis: Hemosuccus Pancreaticus and Pancreaticocolic Fistula
Case Reports of Intravascular Treatment for Gastrointestinal Bleeding Associated with Pancreatitis: Hemosuccus Pancreaticus and Pancreaticocolic Fistula Open
Elderly patients with a history of chronic alcoholism presented to our hospital with episodes of melena, abdominal pain, and anemia. During admission, hemorrhagic cystic lesion at the pancreas was observed on abdominal CT. Transcatheter an…
View article: Experience of Ultrasound-Guided Vacuum-Assisted Excision of a Phyllodes Tumor Arising From Ectopic Axillary Breast Tissue: A Case Report
Experience of Ultrasound-Guided Vacuum-Assisted Excision of a Phyllodes Tumor Arising From Ectopic Axillary Breast Tissue: A Case Report Open
: An axillary breast is a common condition, which can cause various diseases arising from the breast tissue. Among these diseases, phyllodes tumors are very rare fibroepithelial tumors, which resemble fibroadenomas. Surgical removal is the…
View article: Clinicopathological Characteristics and Recurrence-Free Survival of Rare Variants of Papillary Thyroid Carcinomas in Korea: A Retrospective Study
Clinicopathological Characteristics and Recurrence-Free Survival of Rare Variants of Papillary Thyroid Carcinomas in Korea: A Retrospective Study Open
In this multicenter Korean cohort, rare variants accounted for 1.1% of all PTC cases, with TCV being the most frequent subtype. DSV emerged as a significant prognostic factor for RFS.
View article: Efficacy and safety of switching from reference adalimumab to CT-P17 (100 mg/ml): 52-week randomized, double-blind study in rheumatoid arthritis
Efficacy and safety of switching from reference adalimumab to CT-P17 (100 mg/ml): 52-week randomized, double-blind study in rheumatoid arthritis Open
Objective To compare the safety and efficacy of switching from reference adalimumab to adalimumab biosimilar CT-P17 with continuing reference adalimumab/CT-P17 in active RA. Methods This double-blind, phase III study randomized (1:1) subje…
View article: Impact of the ultrasonography assessment method on the malignancy risk and diagnostic performance of five risk stratification systems in thyroid nodules
Impact of the ultrasonography assessment method on the malignancy risk and diagnostic performance of five risk stratification systems in thyroid nodules Open
Purpose Ultrasonographic (US) assessment methods may affect the estimated malignancy risk of thyroid nodules. This study aimed to investigate the impact of retrospective and prospective US assessments on the estimated malignancy risk of US…
View article: Radiofrequency Ablation of Papillary Thyroid Microcarcinoma: A 10-Year Follow-Up Study
Radiofrequency Ablation of Papillary Thyroid Microcarcinoma: A 10-Year Follow-Up Study Open
RFA may be effective and safe to treat low-risk PTMC in patients who refuse or are ineligible for surgery.
View article: Effect of Intra- and Postoperative Fluid and Blood Volume on Postoperative Pulmonary Edema in Patients With Intraoperative Massive Bleeding: Multi-Center Cohort Study Using Time Varying Analysis
Effect of Intra- and Postoperative Fluid and Blood Volume on Postoperative Pulmonary Edema in Patients With Intraoperative Massive Bleeding: Multi-Center Cohort Study Using Time Varying Analysis Open
BackgroundIn patients with massive bleeding during surgery, the effect of intra- and postoperative fluid and blood volume on postoperative pulmonary edema is uncertain. The aim of this study is evaluating the occurrence risk relationship t…
View article: Pycnogenol® Supplementation Attenuates Memory Deficits and Protects Hippocampal CA1 Pyramidal Neurons via Antioxidative Role in a Gerbil Model of Transient Forebrain Ischemia
Pycnogenol® Supplementation Attenuates Memory Deficits and Protects Hippocampal CA1 Pyramidal Neurons via Antioxidative Role in a Gerbil Model of Transient Forebrain Ischemia Open
Pycnogenol® (an extract of the bark of French maritime pine tree) is used for dietary supplement and known to have excellent antioxidative efficacy. However, there are few reports on neuroprotective effect of Pycnogenol® supplementation an…
View article: Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines
Effects of Decursin and Angelica gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines Open
This current study investigates the facilitative effects and mechanisms of decursin, a major component of Angelica gigas Nakai (AGN), and AGN root extract on hair growth in mice. We perform high-performance liquid chromatography on AGN ext…
View article: Laminarin Attenuates Ultraviolet-Induced Skin Damage by Reducing Superoxide Anion Levels and Increasing Endogenous Antioxidants in the Dorsal Skin of Mice
Laminarin Attenuates Ultraviolet-Induced Skin Damage by Reducing Superoxide Anion Levels and Increasing Endogenous Antioxidants in the Dorsal Skin of Mice Open
A number of studies have demonstrated that marine carbohydrates display anti-oxidant, anti-melanogenic, and anti-aging activities in the skin. Laminarin (LA), a low-molecular-weight polysaccharide, is found in brown algae. The benefits of …
View article: Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus
Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus Open
Neuroinflammation is a primary characteristic of the aging brain. During normal aging, macrophage inflammatory protein‑3α (MIP‑3α) and its receptor C‑C chemokine receptor type 6 (CCR6) serve pivotal roles in the neuroinflammatory process i…
View article: A Case of Cowden Syndrome with Bilateral Breast Cancer: Invasive Carcinoma of No Special Type and Pure Cribriform Carcinoma
A Case of Cowden Syndrome with Bilateral Breast Cancer: Invasive Carcinoma of No Special Type and Pure Cribriform Carcinoma Open
: Cowden syndrome is an uncommon, multi-system disease that increases the risk of breast cancer. The most common breast malignancy is ductal carcinoma including ductal carcinoma in situ or infiltrating ductal carcinoma. Rare types of breas…
View article: Pre-Treatment with Laminarin Protects Hippocampal CA1 Pyramidal Neurons and Attenuates Reactive Gliosis Following Transient Forebrain Ischemia in Gerbils
Pre-Treatment with Laminarin Protects Hippocampal CA1 Pyramidal Neurons and Attenuates Reactive Gliosis Following Transient Forebrain Ischemia in Gerbils Open
Transient brain ischemia triggers selective neuronal death/loss, especially in vulnerable regions of the brain including the hippocampus. Laminarin, a polysaccharide originating from brown seaweed, has various pharmaceutical properties inc…
View article: Altered Nurr1 protein expression in the hippocampal CA1 region following transient global cerebral ischemia
Altered Nurr1 protein expression in the hippocampal CA1 region following transient global cerebral ischemia Open
Nuclear receptor related 1 protein (Nurr1), a member of the nuclear receptor 4 family of orphan nuclear receptors, has been reported to display anti‑inflammatory properties. The present study investigated the alteration of Nurr1 immunoreac…
View article: Pre- and Post-Treatment with Novel Antiepileptic Drug Oxcarbazepine Exerts Neuroprotective Effect in the Hippocampus in a Gerbil Model of Transient Global Cerebral Ischemia
Pre- and Post-Treatment with Novel Antiepileptic Drug Oxcarbazepine Exerts Neuroprotective Effect in the Hippocampus in a Gerbil Model of Transient Global Cerebral Ischemia Open
Oxcarbazepine, an antiepileptic drug, has been reported to modulate voltage-dependent sodium channels, and it is commonly used in epilepsy treatment. In this study, we investigated the neuroprotective effect of oxcarbazepine in the hippoca…
View article: Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress
Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress Open
Compelling evidence from preclinical and clinical studies has shown that mild hypothermia is neuroprotective against ischemic stroke. We investigated the neuroprotective effect of post-risperidone (RIS) treatment against transient ischemic…
View article: Does Post-Biopsy Mammography at Short-Term Interval Contribute to Early Detection of Cancer in Patients Diagnosed with Benign-Concordant Microcalcifications on Stereotactic Biopsy?
Does Post-Biopsy Mammography at Short-Term Interval Contribute to Early Detection of Cancer in Patients Diagnosed with Benign-Concordant Microcalcifications on Stereotactic Biopsy? Open
Background: Currently, there are no strict post-biopsy guidelines for managing stereotactic biopsy-proven benign lesions manifesting as microcalcifications on mammography without an accompanying mass. \n\n\nObjectives: To evaluate whether …
View article: Time-course pattern of neuronal loss and gliosis in gerbil hippocampi following mild, severe, or lethal transient global cerebral ischemia
Time-course pattern of neuronal loss and gliosis in gerbil hippocampi following mild, severe, or lethal transient global cerebral ischemia Open
Transient ischemia in the whole brain leads to neuronal loss/death in vulnerable brain regions. The striatum, neocortex and hippocampus selectively loose specific neurons after transient ischemia. Just 5 minutes of transient ischemia can c…
View article: Comparison of CT Findings of Non-Tuberculous Mycobacterial Pulmonary Infection: Disease Stable versus Progressed Group
Comparison of CT Findings of Non-Tuberculous Mycobacterial Pulmonary Infection: Disease Stable versus Progressed Group Open
Purpose: To compare initial CT findings of non-tuberculous mycobacteria (NTM) pulmonary infection between stable and progressed groups and determine whether they could be used to predict disease prognosis and treatment response. Materials …
View article: Intraventricular hemorrhage after acupuncture
Intraventricular hemorrhage after acupuncture Open
Acupuncture is a traditional treatment method that has been extensively used for centuries in a number of Asian countries for pain control as well as for treatment of various diseases. Acupuncture has been known to be a safe procedure with…
View article: The effect of first nocturnal ejaculation timing on risk and sexual behaviors of Korean male adolescents
The effect of first nocturnal ejaculation timing on risk and sexual behaviors of Korean male adolescents Open
There is a positive association between early nocturnal ejaculation and sexual behaviors in male adolescents. Proactive education about sexual behaviors is required for adolescents who reach sexual maturity early.