Gohar Tsakanova
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View article: In silico and in vitro evaluation of drug-like properties and anticancer potential of novel 5-fluorouracil derivatives
In silico and in vitro evaluation of drug-like properties and anticancer potential of novel 5-fluorouracil derivatives Open
The development of more effective and safer anticancer agents remains a critical focus in cancer therapy. While biologics are gaining attention, small molecules continue to play a significant role due to their versatility and cost-effectiv…
View article: The Effect of Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation on Erythropoiesis and Oxidative Stress in Rats
The Effect of Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation on Erythropoiesis and Oxidative Stress in Rats Open
Anemia is a commonly observed consequence of whole-body exposure to a dose of X-ray or gamma irradiation of the order of the mean lethal dose in mammals, and it is an important factor for the determination of the survival of animals. The a…
View article: Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats Open
The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in …
View article: Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke
Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke Open
In conclusion, we suggest that LCP PRMs are associated with the risk of developing IS, and may also participate in pathological events leading to post-ischemic brain damage. This study emphasizes the important contribution of alterations o…
View article: The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro
The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro Open
For the last years, copper complexes have been intensively implicated in biomedical research as components of cancer treatment. Herewith, we provide highlights of the synthesis, physical measurements, structural characterization of the new…
View article: X-ray-Based Techniques to Study the Nano–Bio Interface
X-ray-Based Techniques to Study the Nano–Bio Interface Open
X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques in the life sciences and medicine, however, has not yet been fully exploite…
View article: DNA double-strand break repair efficiency in cancer cells exposed to laser-driven ultrashort electron beams
DNA double-strand break repair efficiency in cancer cells exposed to laser-driven ultrashort electron beams Open
Anna A. Oleshkevich, Specific features of change in enzymate activity in
View article: Low Repair Capacity of DNA Double-Strand Breaks Induced by Laser-Driven Ultrashort Electron Beams in Cancer Cells
Low Repair Capacity of DNA Double-Strand Breaks Induced by Laser-Driven Ultrashort Electron Beams in Cancer Cells Open
Laser-driven accelerators allow to generate ultrashort (from femto- to picoseconds) high peak dose-rate (up to tens of GGy/s) accelerated particle beams. However, the radiobiological effects of ultrashort pulsed irradiation are still poorl…
View article: Two-photon imaging of oxidative stress in living erythrocytes as a measure for human aging
Two-photon imaging of oxidative stress in living erythrocytes as a measure for human aging Open
According to the “oxidative stress theory” of aging, this process is accompanied by a progressive and irreversible accumulation of oxidative damage caused by reactive oxygen species (ROS). This, in turn, has a deleterious impact on molecul…
View article: Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke
Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke Open
In conclusion, our findings suggest that the NGF rs6330*T and NGFR rs2072446*T minor alleles might be nominated as a risk factor for developing ischemic stroke and NGFR rs734194*G minor allele as a protective against this disease at least …
View article: Two-photon microscopy imaging of oxidative stress in human living erythrocytes
Two-photon microscopy imaging of oxidative stress in human living erythrocytes Open
Red blood cells (RBCs) are known to be the most suitable cells to study oxidative stress, which is implicated in the etiopathology of many human diseases. The goal of the current study was to develop a new effective approach for assessing …
View article: Dose-rate effect of ultrashort electron beam radiation on DNA damage and repair in vitro
Dose-rate effect of ultrashort electron beam radiation on DNA damage and repair in vitro Open
Laser-generated electron beams are distinguished from conventional accelerated particles by ultrashort beam pulses in the femtoseconds to picoseconds duration range, and their application may elucidate primary radiobiological effects. The …
View article: Activated complement protein C5a does not affect brain-derived endothelial cell viability and zonula occludens-1 levels following oxygen-glucose deprivation
Activated complement protein C5a does not affect brain-derived endothelial cell viability and zonula occludens-1 levels following oxygen-glucose deprivation Open
BACKGROUND AND PURPOSE: Ischemic brain injury induces both functional and structural disarray affecting the blood–brain barrier (BBB) which in return aggravates stroke outcomes. Complement system and its bioactive proteins are important mo…
View article: Oxidative Stress and Post-Ischemic Inflammatory Response in Ischemic Stroke Complicated with Diabetes Mellitus Type 2
Oxidative Stress and Post-Ischemic Inflammatory Response in Ischemic Stroke Complicated with Diabetes Mellitus Type 2 Open
Oxidative stress and post-ischemic inflammatory response are the key pathogenic mechanisms of the neuronal injury caused by ischemic stroke (IS). On the other hand, Diabetes is a major risk factor for the development of stroke, increasing …