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View article: Do We Need Meropenem Treatment Beyond 7 Days in Febrile Neutropenic Patients: A Cost-Effectiveness Analysis
Do We Need Meropenem Treatment Beyond 7 Days in Febrile Neutropenic Patients: A Cost-Effectiveness Analysis Open
Background: Febrile neutropenia is a critical complication in patients with hematological malignancies; immediate initiation of empirical treatment with a broad-spectrum agent is the standard of care. In this study, we aimed to evaluate th…
View article: Quantitative Immunoglobulin G and Interferon-Gamma Responses After Different Booster Strategies of CoronaVac and BNT162b2 Vaccines in Türkiye
Quantitative Immunoglobulin G and Interferon-Gamma Responses After Different Booster Strategies of CoronaVac and BNT162b2 Vaccines in Türkiye Open
Our findings revealed that although homologous and heterologous boosting in inactivated vaccine-primed individuals provided effective humoral and cellular immunity, boosting with two doses of BNT162b2 should be prioritized since it exhibit…
View article: Therapeutic drug monitoring in patients treated with vancomycin: a single center, prospective, observational, real-world study
Therapeutic drug monitoring in patients treated with vancomycin: a single center, prospective, observational, real-world study Open
Purpose Therapeutic drug monitoring of vancomycin targeting an AUC/MIC ratio of 400–650 mg*h/L is required to ensure optimal therapeutic efficacy and safety in patients treated with vancomycin. The objectives of this study were to monitor …
View article: A scoring system to predict resistance to ceftolozane/tazobactam in respiratory isolates of <i>Pseudomonas aeruginosa</i>
A scoring system to predict resistance to ceftolozane/tazobactam in respiratory isolates of <i>Pseudomonas aeruginosa</i> Open
Objectives To develop a scoring system to predict resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa strains isolated from respiratory specimens. Methods A case–control study was conducted to evaluate the risk factors associate…
View article: Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant <i>Enterobacterales</i> bloodstream infection: a case-control study
Duration of intensive care unit stay as a guide for the timely treatment of Carbapenem-resistant <i>Enterobacterales</i> bloodstream infection: a case-control study Open
Timely selection of appropriate empirical treatment for carbapenem-resistant Enterobacterales (CRE) bacteremia remains challenging, especially when prior antibiotic exposure data is unavailable. We found that intensive care unit stay durat…
View article: Comparison of the effect of carbapenem and piperacillin-tazobactam on the development of fecal colonization with carbapenem resistant Enterobacterales
Comparison of the effect of carbapenem and piperacillin-tazobactam on the development of fecal colonization with carbapenem resistant Enterobacterales Open
BACKGROUND: Both carbapenem and piperacillin-tazobactam (TZP) use have been reported as risk factors for carbepenem-resistant Enterobacterales (CRE) infections. AIM: We aimed to investigate the effect of carbapenem and TZP use on the devel…
View article: Safety of discontinuation of contact precautions in patients with multidrug resistant bacteria infection or colonization
Safety of discontinuation of contact precautions in patients with multidrug resistant bacteria infection or colonization Open
AIM: To identify the safety of an institutional protocol to discontinue contact precautions (CP) in patients with multidrug-resistant bacteria (MDRB) infection/colonization. BACKGROUND: CP are critical in preventing MDRB spread in hospital…
View article: Effect of inflammation on voriconazole levels in patients with invasive pulmonary aspergillosis
Effect of inflammation on voriconazole levels in patients with invasive pulmonary aspergillosis Open
Introduction: Voriconazole (VCZ) serum concentrations may be affected by many factors, such as drug-drug interactions, liver dysfunction, genetic polymorphism, and inflammation. This study aimed to determine the relationship between VCZ me…
View article: An Institutional Febrile Neutropenia Protocol Improved the Antibacterial Treatment and Encouraged the Development of a Computerized Clinical Decision Support System
An Institutional Febrile Neutropenia Protocol Improved the Antibacterial Treatment and Encouraged the Development of a Computerized Clinical Decision Support System Open
We investigated the influence of a local guideline on the quality of febrile neutropenia (FN) management and the applicability of a computerized decision support system (CDSS) using real-life data. The study included 227 FN patients betwee…
View article: WHICH TOOL IS THE BEST GUIDE OPTIMIZE THE VORICONAZOLE DOSAGE: THERAPEUTIC DRUG MONITORING OR CYTOCHROME P450 POLYMORPHISM?
WHICH TOOL IS THE BEST GUIDE OPTIMIZE THE VORICONAZOLE DOSAGE: THERAPEUTIC DRUG MONITORING OR CYTOCHROME P450 POLYMORPHISM? Open
Voriconazole (VCZ) is the drug of choice for invasive aspergillosis (IA). However, narraow therapeutic range and variable pharmacokinetics can effect the success of the therapy. VCZ serum concentration is influenced by several factor inclu…
View article: The Impact of Reporting the Same-Day Identification and Antibiotic Susceptibility Test Results on the Treatment of Bloodstream Infections
The Impact of Reporting the Same-Day Identification and Antibiotic Susceptibility Test Results on the Treatment of Bloodstream Infections Open
Implementation of rapid ID and AST may contribute to patient management. Although rapid reporting was made, some results were not evaluated by the clinician on the same day, indicating that communication between the clinician and the labor…
View article: RETRACTED: Impact of Aspergillus PCR on the Management of Invasive Aspergillosis: A Tertiary-care Hospital Experience during the COVID-19 Pandemic
RETRACTED: Impact of Aspergillus PCR on the Management of Invasive Aspergillosis: A Tertiary-care Hospital Experience during the COVID-19 Pandemic Open
The authors have requested that this preprint be removed from Research Square.
View article: RETRACTED: The Impact of Hospital-Specific Guidelines on Carbapenem Use and Patient Outcomes in a Setting for High Endemicity with Multidrug-Resistant Gram-Negative Bacilli
RETRACTED: The Impact of Hospital-Specific Guidelines on Carbapenem Use and Patient Outcomes in a Setting for High Endemicity with Multidrug-Resistant Gram-Negative Bacilli Open
The authors have requested that this preprint be removed from Research Square.
View article: Lectin Microarray Analysis of Antibodies to SARS-CoV-2 Elicited by COVID-19 mRNA Vaccine BNT162b2
Lectin Microarray Analysis of Antibodies to SARS-CoV-2 Elicited by COVID-19 mRNA Vaccine BNT162b2 Open
The outstanding clinical efficacy of mRNA vaccines to the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has shown a new direction in vaccine design and development. Accumulation of knowledge on neutralizing antibodies induce…
View article: Comparison of two surveillance criteria for detecting ventilator associated problems in critically- ill patients who have COVID-19
Comparison of two surveillance criteria for detecting ventilator associated problems in critically- ill patients who have COVID-19 Open
Background We aimed to compare the effectiveness of traditional Ventilator associated pneumonia (VAP) and Ventilator associated event (VAE) surveillance definitions in the determination of mechanical ventilator related infectious complicat…
View article: The impact of hospital-specific guidelines on carbapenem use and patient outcomes in a setting for high endemicity with multidrug-resistant gram-negative bacilli
The impact of hospital-specific guidelines on carbapenem use and patient outcomes in a setting for high endemicity with multidrug-resistant gram-negative bacilli Open
Objective: This study aims to assess the impact of hospital-specific guidelines on the optimal utilization of carbapenems and to examine their effects on patient outcomes. Design: Quasi-experimental study. Setting: Tertiary care hospital i…
View article: Diagnostic performance and longitudinal analysis of fungal biomarkers in COVID-19 associated pulmonary aspergillosis
Diagnostic performance and longitudinal analysis of fungal biomarkers in COVID-19 associated pulmonary aspergillosis Open
GM-LFA, particularly in NBL samples, seems to be a reliable method for CAPA diagnosis. For detecting patients with higher risk of mortality, longitudinal measurement of serum GM-ELISA can be useful.
View article: Knowledge of isolation precautions among the healthcare workers in the emergency department of a university hospital
Knowledge of isolation precautions among the healthcare workers in the emergency department of a university hospital Open
Objectives: Prevention and control of healthcare-associated infections are important for patients and personal safety and for fighting against antimicrobial resistance. In order to achieve the goal of zero infection, it is necessary to kno…
View article: Cessation of Rectal Screening for Vancomycin-Resistant Enterococci: Experience from a Tertiary Care Hospital from Türkiye
Cessation of Rectal Screening for Vancomycin-Resistant Enterococci: Experience from a Tertiary Care Hospital from Türkiye Open
Objective: Here, we compared the impact of different polices on the epidemiology of Vancomycin-resistant Enterococcus faecium bloodstream infections (VRE-BSIs) in a tertiary care hospital including two hospital buildings (oncology and adul…
View article: Use of molnupiravir in patients who developed SARS-CoV2-Infection during hospitalization
Use of molnupiravir in patients who developed SARS-CoV2-Infection during hospitalization Open
Background: Molnupiravir is an oral anti-viral that inhibits SARS-CoV-2 replication and reduces viral load. We aimed to investigate mortality rates and the factors affecting mortality in patients receiving molnupiravir who were hospitalize…
View article: Evaluation of Cleaning and Disinfection with Fluorescent Marking in Intensive Care Units and Importance of Cross-Monitoring
Evaluation of Cleaning and Disinfection with Fluorescent Marking in Intensive Care Units and Importance of Cross-Monitoring Open
ÖZ Giriş: Bu çalışmanın amacı, yoğun bakım ünitelerinde (YBÜ) temizlik ve dezenfeksiyon sürecini gözden geçirmenin ve yapılan çapraz denetimlerin önemini
View article: Evaluation of Quantitative IgG and Interferon-Gamma Responses After Different Booster Strategies of CoronaVac and BNT162b2 Vaccines in Turkey
Evaluation of Quantitative IgG and Interferon-Gamma Responses After Different Booster Strategies of CoronaVac and BNT162b2 Vaccines in Turkey Open
Background The global effort to combat the COVID-19 pandemic requires a comprehensive assessment of vaccine efficacy, humoral and cellular immune responses. The current study aimed to determine the effects of CoronaVac and BNT162b2 booster…
View article: Impact of a hospital sepsis management protocol on the selection of empirical antibiotics in infectious disease consultations
Impact of a hospital sepsis management protocol on the selection of empirical antibiotics in infectious disease consultations Open
It is well-established that Infectious Diseases consultation (IDC) enhances the prognosis of bloodstream infections. However, it is unclear if adoption of an institutional sepsis protocol would lead to any further improvement in a setting …
View article: Back to the First Days of the Pandemic: How Well Have We Done to Diagnose COVID-19 in Healthcare Workers?
Back to the First Days of the Pandemic: How Well Have We Done to Diagnose COVID-19 in Healthcare Workers? Open
Introduction: Healthcare workers (HCWs) are one of the most vulnerable groups for COVID-19.SARS-CoV-2 PCR was offered to HCWs who had symptoms compatible with COVID-19 or who had a close contact with COVID-19 patient.A rapid antibody test …
View article: Evaluation of risk factors for developing COVID-19 in healthcare professionals working at two university hospitals in Turkey
Evaluation of risk factors for developing COVID-19 in healthcare professionals working at two university hospitals in Turkey Open
BACKGROUND: Healthcare workers (HCWs) were seriously affected by the coronavirus disease 2019 (COVID-19). It is a priority to protect HCWs against COVID-19 and ensure the continuity of the health care system. OBJECTIVE: To evaluate the ris…
View article: Impact of HLA Polymorphism on the Immune Response to Bacillus Anthracis Protective Antigen in Vaccination versus Natural Infection
Impact of HLA Polymorphism on the Immune Response to Bacillus Anthracis Protective Antigen in Vaccination versus Natural Infection Open
The causative agent of anthrax, Bacillus anthracis, evades the host immune response and establishes infection through the production of binary exotoxins composed of Protective Antigen (PA) and one of two subunits, lethal factor (LF) or ede…
View article: The impact of COVID-19 pandemic on nosocomial multidrug-resistant bacterial bloodstream infections and antibiotic consumption in a tertiary care hospital
The impact of COVID-19 pandemic on nosocomial multidrug-resistant bacterial bloodstream infections and antibiotic consumption in a tertiary care hospital Open
We investigated the change in the epidemiology of nosocomial bloodstream infections (BSIs) caused by multidrug-resistant bacteria during Coronavirus Disease (COVID-19) and antibiotic consumption rates at a pandemic hospital and at the Onco…