Gongxun Zhong
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View article: Transmission of SARS-CoV-2 between ferrets in presence of pre-existing immunity
Transmission of SARS-CoV-2 between ferrets in presence of pre-existing immunity Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), is characterized by its high contagiousness. The COVID-19 pandemic has exerted profound impacts on human society. T…
View article: Homoharringtonine is highly effective against SARS-CoV-2: a potential first-line defense in future coronavirus epidemics
Homoharringtonine is highly effective against SARS-CoV-2: a potential first-line defense in future coronavirus epidemics Open
As COVID-19 is the third coronavirus epidemic in this century, it would be desirable to have a treatment scheme in anticipation of a fourth one. We here present a scheme that could clear SARS-CoV-2 in 2–4 days post-infection from the upper…
View article: Safety and immunogenicity of a SARS-CoV-2 mRNA vaccine (SYS6006) in minks, cats, blue foxes, and raccoon dogs
Safety and immunogenicity of a SARS-CoV-2 mRNA vaccine (SYS6006) in minks, cats, blue foxes, and raccoon dogs Open
Minks, cats, and some other species of carnivores are susceptible of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and have a high risk of transmitting SARS-CoV-2 to humans. The development of animal vaccines can be an e…
View article: Rabies virus-based oral and inactivated vaccines protect minks against SARS-CoV-2 infection and transmission
Rabies virus-based oral and inactivated vaccines protect minks against SARS-CoV-2 infection and transmission Open
Minks are highly susceptible to SARS-CoV-2, and have transmitted SARS-CoV-2 to humans. Oral immunization is one of the most promising strategies to prevent SARS-CoV-2 infection and transmission in minks. Here, we generated 3 recombinant ra…
View article: Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1
Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1 Open
View article: Highly Pathogenic H5 Influenza Viruses Isolated between 2016 and 2017 in Vietnamese Live Bird Markets
Highly Pathogenic H5 Influenza Viruses Isolated between 2016 and 2017 in Vietnamese Live Bird Markets Open
Routine surveillance in live poultry markets in the northern regions of Vietnam from 2016 to 2017 resulted in the isolation of 27 highly pathogenic avian H5N1 and H5N6 viruses of 3 different clades (2.3.2.1c, 2.3.4.4f, and 2.3.4.4g). Seque…
View article: Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro
Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro Open
The 3C-like protease (3CLpro) is an essential enzyme for the replication of SARS-CoV-2 and other coronaviruses and thus is a target for coronavirus drug discovery. Nearly all inhibitors of coronavirus 3CLpro reported so far are covalent in…
View article: Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022)
Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022) Open
RNA‐Dependent RNA Polymerase In article number 2203499, Zhigao Bu, Lingbo Qu, Maozhi Ren, Fuguang Li, and co‐workers report that gossypol, a natural product from cotton plant, can efficiently inhibit SARS‐CoV‐2 variants by targeting RNA‐de…
View article: Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases
Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases Open
Outbreaks of coronaviruses (CoVs), especially severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), have posed serious threats to humans and animals, which urgently calls for effective broad‐spectrum antivirals. RNA‐dependent RNA p…
View article: Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro
Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro Open
The SARS-CoV-2 virus is the causal agent of the ongoing pandemic of coronavirus disease 2019 (COVID-19). There is an urgent need for potent, specific antiviral compounds against SARS-CoV-2. The 3C-like protease (3CLpro) is an essential enz…
View article: Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Open
View article: Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung Open
The continuous emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2) variants and the increasing number of breakthrough infection cases among vaccinated people support the urgent need for research and development of antiviral dr…
View article: Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor
Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor Open
Some key mutations of SARS-CoV-2 spike protein, such as D614G and P681R mutations, increase the transmission or pathogenicity by enhancing the cleavage efficacy of spike protein by furin. Loss of the furin cleavage motif of SARS-CoV-2 spik…
View article: Author Correction: SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells
Author Correction: SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells Open
In the original publication of this article 1 , we made some mistakes in Fig. 4c andd.The layer of nucleus was missing in the images of CK5 and CK8 of Fig. 4c, and the layer of Ace2 was shifted in the image of Ace2 of Fig. 4d.The correctly…
View article: SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells
SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells Open
View article: Novel sites for Cathepsin L cleavage in SARS-CoV-2 spike guide treatment strategies
Novel sites for Cathepsin L cleavage in SARS-CoV-2 spike guide treatment strategies Open
The spike (S) protein of SARS coronavirus 2 (SARS-CoV-2) is an ideal target for the development of specific vaccines or drugs. However, treatments targeting viruses with mutant S proteins that have recently emerged in many countries are li…
View article: Metabotropic glutamate receptor subtype 2 is a receptor of SARS-CoV-2
Metabotropic glutamate receptor subtype 2 is a receptor of SARS-CoV-2 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative pathogen of novel coronavirus disease 2019 (COVID-19)1. SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as a cellular receptor and enters cells via clathr…
View article: Plasticity of the Influenza Virus H5 HA Protein
Plasticity of the Influenza Virus H5 HA Protein Open
The HA protein of influenza A viruses is the major viral antigen. In this study, we simultaneously introduced mutations at 17 amino acid positions of an H5 HA expected to affect antigenicity. Viruses with ≥13 amino acid changes in HA were …
View article: Replication, pathogenicity, and transmission of SARS-CoV-2 in minks
Replication, pathogenicity, and transmission of SARS-CoV-2 in minks Open
Minks are raised in many countries and have transmitted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to humans. However, the biologic properties of SARS-CoV-2 in minks are largely unknown. Here, we investigated and found th…
View article: A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge
A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge Open
The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a sin…
View article: Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice
Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice Open
View article: A single dose of an adenovirus-vectored vaccine provides complete protection of the upper and lower respiratory tracts against SARS-CoV-2 challenge
A single dose of an adenovirus-vectored vaccine provides complete protection of the upper and lower respiratory tracts against SARS-CoV-2 challenge Open
The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we found that a si…
View article: Characterizing Emerging Canine H3 Influenza Viruses.
Characterizing Emerging Canine H3 Influenza Viruses. Open
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses…
Characterizing Emerging Canine H3 Influenza Viruses Open
View article: Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2 Open
Alternative hosts and model animals The severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) pandemic may have originated in bats, but how it made its way into humans is unknown. Because of its zoonotic origins, SARS-CoV-2 is unlik…
View article: Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2
Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19, which was first reported in Wuhan, China in December, 2019. Despite the tremendous efforts to control the disease, COVID-19 has now spread…
View article: Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets
Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets Open
Bats are reservoirs for several severe zoonotic pathogens. The genomes of influenza A viruses of the H17N10 and H18N11 subtypes have been identified in bats, but no live virus has been isolated. The characterization of artificially generat…
View article: Isolation of Highly Pathogenic H5N1 Influenza Viruses in 2009–2013 in Vietnam
Isolation of Highly Pathogenic H5N1 Influenza Viruses in 2009–2013 in Vietnam Open
Routine surveillance and surveillance in response to influenza outbreaks in avian species in Vietnam in 2009-2013 resulted in the isolation of numerous H5N1 influenza viruses of clades 1.1.2, 2.3.2.1a, 2.3.2.1b, 2.3.2.1c, and 2.3.4.1. Cons…
View article: Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus
Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus Open
The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenical…
View article: Diversity of Influenza A(H5N1) Viruses in Infected Humans, Northern Vietnam, 2004–2010
Diversity of Influenza A(H5N1) Viruses in Infected Humans, Northern Vietnam, 2004–2010 Open
Influenza viruses exist in each host as a collection of genetically diverse variants, which might enhance their adaptive potential. To assess the genetic and functional diversity of highly pathogenic avian influenza A(H5N1) viruses within …