Gongyong Peng
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View article: Carnosol attenuates <i>Acinetobacter baumannii</i> virulence by interfering with indole-mediated quorum sensing
Carnosol attenuates <i>Acinetobacter baumannii</i> virulence by interfering with indole-mediated quorum sensing Open
Many bacterial pathogens utilize quorum sensing (QS) signals to modulate the biological functions in a cell density-dependent manner. Acinetobacter baumannii is a harmful pathogen and a major cause of hospital-acquired infections du…
View article: A cell-cell communication signal from <i>Enterobacter cloacae</i> interfering with the signaling systems and virulence in <i>Shigella sonnei</i>
A cell-cell communication signal from <i>Enterobacter cloacae</i> interfering with the signaling systems and virulence in <i>Shigella sonnei</i> Open
Quorum sensing (QS) is widely utilized by both bacteria and fungi to mediate cell-cell communication. Previous studies have demonstrated that the indole derivative indole-3-ethanol (also known as tryptophol) controls morphogenesis as a QS …
View article: CrossLoc: Disentangling Cross-Temporal and Cross-Dimensional Features for Robust Geomagnetic Indoor Localization
CrossLoc: Disentangling Cross-Temporal and Cross-Dimensional Features for Robust Geomagnetic Indoor Localization Open
View article: Chronic hypoxia promotes pulmonary venous smooth muscle cell proliferation through the CaSR-TRPC6/ROCE pathway
Chronic hypoxia promotes pulmonary venous smooth muscle cell proliferation through the CaSR-TRPC6/ROCE pathway Open
The mechanism underlying chronic hypoxia (CH)-induced pulmonary venous remodeling remains unclear. Cell proliferation is key in vascular remodeling, and the calcium-sensing receptor (CaSR) protein contributes to CH-induced pulmonary venous…
View article: Corrigendum to “A comprehensive study on ultrasonic deactivation of opportunistic pathogen Saccharomyces cerevisiae in food processing: From transcriptome to phenotype” [LWT, volume 170, article 114069]
Corrigendum to “A comprehensive study on ultrasonic deactivation of opportunistic pathogen Saccharomyces cerevisiae in food processing: From transcriptome to phenotype” [LWT, volume 170, article 114069] Open
View article: Novel Role of Calcium-Sensitive Receptors in Chronic Hypoxia-Induced Proliferation of Pulmonary Vein Smooth Muscle Cells
Novel Role of Calcium-Sensitive Receptors in Chronic Hypoxia-Induced Proliferation of Pulmonary Vein Smooth Muscle Cells Open
Objective: Vascular remodeling due to chronic hypoxia (CH) occurs not only in the pulmonary arteries but also in the pulmonary veins. Pulmonary vascular remodeling arises from the proliferation of pulmonary vascular myocytes. However, the …
View article: Disease-associated gut microbiome and metabolome changes in rats with chronic hypoxia-induced pulmonary hypertension
Disease-associated gut microbiome and metabolome changes in rats with chronic hypoxia-induced pulmonary hypertension Open
Background Pulmonary hypertension (PH) is a progressive disease affecting the lung vasculature that is characterized by sustained vasoconstriction and leads to vascular remodeling. The lung microbiome contributes to PH progression, but the…
View article: Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades
Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades Open
Due to the lack of effective treatments, osteoarthritis (OA) remains a challenge for clinicians. Quercetin, a bioflavonoid, has shown potent anti‐inflammatory effects. However, its effect on preventing OA progression and the underlying mec…
View article: Impaired exercise capacity in individuals with non-obstructive small airway dysfunction
Impaired exercise capacity in individuals with non-obstructive small airway dysfunction Open
Although not meeting the current criteria for chronic obstructive pulmonary disease, individuals with non-obstructive SAD have impaired exercise capacity that may be associated with ventilatory inefficiency regardless of smoking status.
View article: Pseudomonas aeruginosa: A typical biofilm forming pathogen and an emerging but underestimated pathogen in food processing
Pseudomonas aeruginosa: A typical biofilm forming pathogen and an emerging but underestimated pathogen in food processing Open
Pseudomonas aeruginosa ( P. aeruginosa ) is a notorious gram-negative pathogenic microorganism, because of several virulence factors, biofilm forming capability, as well as antimicrobial resistance. In addition, the appearance of antibioti…
View article: Intense pulsed light for inactivating planktonic and biofilm molds in food
Intense pulsed light for inactivating planktonic and biofilm molds in food Open
It has been reported that about a quarter of the world’s agriculture products is unable to be consumed each year because of mold contamination, resulting in incalculable economic losses. Despite modern food technology and the various prese…
View article: A comprehensive study on ultrasonic deactivation of opportunistic pathogen Saccharomyces cerevisiae in food processing: From transcriptome to phenotype
A comprehensive study on ultrasonic deactivation of opportunistic pathogen Saccharomyces cerevisiae in food processing: From transcriptome to phenotype Open
This study aimed to investigate morphological changes and regulatory mechanism of opportunistic pathogen Saccharomyces cerevisiae upon ultrasonic. Ultrasound intensities (0/102.8/288 W, 10 min) were applied on S. cerevisiae (OD600 = 0.1), …
View article: Neuroinflammation as a Potential Therapeutic Target in Alzheimer’s Disease
Neuroinflammation as a Potential Therapeutic Target in Alzheimer’s Disease Open
Ping Liu,1 Yunyun Wang,1,2 Yan Sun,1 Guoping Peng1 1Department of Neurology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Department of Neurology, Shengzhou People’s Hospital…
View article: Establishment and application of a rapid visual detection method for <i>Listeria monocytogenes</i> based on polymerase spiral reaction (PSR)
Establishment and application of a rapid visual detection method for <i>Listeria monocytogenes</i> based on polymerase spiral reaction (PSR) Open
Listeria monocytogenes is a common foodborne pathogen that presents in various food products, posing important threat to public health. The aim of this study was to establish a rapid and sensitive method with visualization to detect…
View article: Regulatory network controls microbial biofilm development, with <i>Candida albicans</i> as a representative: from adhesion to dispersal
Regulatory network controls microbial biofilm development, with <i>Candida albicans</i> as a representative: from adhesion to dispersal Open
Microorganisms mainly exist in the form of biofilm in nature. Biofilm can contaminate food and drinking water system, as well as cause chronic wound infections, thereby posing a potential threat to public health safety. In the last two dec…
View article: Correction to: Platelet-derived growth factor-BB induces pulmonary venous smooth muscle cells proliferation by upregulating calcium sensing receptor under hypoxic conditions
Correction to: Platelet-derived growth factor-BB induces pulmonary venous smooth muscle cells proliferation by upregulating calcium sensing receptor under hypoxic conditions Open
View article: Lung Features in Individuals with Biomass Smoke Exposure Characterized by CT Scan and Changes in Pulmonary Function
Lung Features in Individuals with Biomass Smoke Exposure Characterized by CT Scan and Changes in Pulmonary Function Open
ChiCTR-OO-14004264.
View article: Lung Damage among Individuals with Biomass Smoke Exposure Characterized by CT Features and Changes in Pulmonary Function
Lung Damage among Individuals with Biomass Smoke Exposure Characterized by CT Features and Changes in Pulmonary Function Open
Background Biomass smoke exposure (BSE) is an important etiological factor in chronic obstructive pulmonary disease (COPD). However, few studies have focused on the effects of BSE in the respiratory muscles or lungs. Methods Using a cohort…
View article: Platelet-derived growth factor-BB induces pulmonary venous smooth muscle cells proliferation by upregulating calcium sensing receptor under hypoxic conditions
Platelet-derived growth factor-BB induces pulmonary venous smooth muscle cells proliferation by upregulating calcium sensing receptor under hypoxic conditions Open
View article: Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis
Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis Open
Although the mechanism of osteoarthritis (OA) has been widely studied and the use of quercetin for OA therapy is well documented, the relevant characteristics of the microbiome and metabolism remain unclear. This study reports changes in t…
View article: Changes in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension
Changes in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension Open
The gut microbiota is widely considered to be involved in several diseases, including atherosclerosis, obesity, chronic obstructive pulmonary disease (COPD) and pulmonary arterial hypertension (PAH). This study aimed to determine if change…
View article: Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema
Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema Open
Pathologic lymphatic remodeling in lymphedema evolves during periods of tissue inflammation and hypoxia through poorly defined processes. In human and mouse lymphedema, there is a significant increase of hypoxia inducible factor 1 α (HIF-1…
View article: Bone Morphogenetic Protein Receptor 2 Mutations Impair T Regulatory Cell Function and Promote Inflammation in Pulmonary Arterial Hypertension
Bone Morphogenetic Protein Receptor 2 Mutations Impair T Regulatory Cell Function and Promote Inflammation in Pulmonary Arterial Hypertension Open
View article: Phenotypically Silent Bone Morphogenetic Protein Receptor 2 Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing the Risk for Neointimal Transformation
Phenotypically Silent Bone Morphogenetic Protein Receptor 2 Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing the Risk for Neointimal Transformation Open
Background: Bmpr2 (bone morphogenetic protein receptor 2) mutations are critical risk factors for hereditary pulmonary arterial hypertension (PAH) with approximately 20% of carriers developing disease. There is an unmet medical need to und…
View article: PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway
PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway Open
These findings suggest that PM2.5, which may exert its effects through the Shh signaling pathway, is necessary for the migration of HBSMCs. These data define a novel role for PM2.5 in airway remodeling in COPD.
View article: Isolation, culture and identification of pulmonary arterial smooth muscle cells from rat distal pulmonary arteries
Isolation, culture and identification of pulmonary arterial smooth muscle cells from rat distal pulmonary arteries Open
View article: Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR
Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR Open
Background/Aims: The proliferation of human bronchial smooth muscle cells (HBSMCs) is a key pathophysiological component of airway remodeling in chronic obstructive pulmonary disease (COPD) for which pharmacotherapy is limited, and only sl…
View article: Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD
Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD Open
D-dimer was a strong and independent risk factor for in-hospital and 1-year death for AECOPD patients.
View article: Chronic Hypoxia Increases Intracellular Ca<sup>2+</sup> Concentration via Enhanced Ca<sup>2+</sup> Entry Through Receptor-Operated Ca<sup>2+</sup> Channels in Pulmonary Venous Smooth Muscle Cells
Chronic Hypoxia Increases Intracellular Ca<sup>2+</sup> Concentration via Enhanced Ca<sup>2+</sup> Entry Through Receptor-Operated Ca<sup>2+</sup> Channels in Pulmonary Venous Smooth Muscle Cells Open
The enhanced Ca(2+)entry through ROCC, due to upregulated TRPC6, is a novel pathogenic mechanism contributing to the increased basal [Ca(2+)]iin PVSMCs and excessive PVSMC proliferation during the development of HPH.
View article: CORRIGENDUM: Chronic Hypoxia Increases Intracellular Ca<sup>2+</sup> Concentration via Enhanced Ca<sup>2+</sup> Entry Through Receptor-Operated Ca<sup>2+</sup> Channels in Pulmonary Venous Smooth Muscle Cells
CORRIGENDUM: Chronic Hypoxia Increases Intracellular Ca<sup>2+</sup> Concentration via Enhanced Ca<sup>2+</sup> Entry Through Receptor-Operated Ca<sup>2+</sup> Channels in Pulmonary Venous Smooth Muscle Cells Open