Gonzalo Carrasco-Aviño
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View article: Cellulosimicrobium cellulans
Cellulosimicrobium cellulans Open
View article: Characterization of Screening Strategies for Lynch Syndrome in Latin America
Characterization of Screening Strategies for Lynch Syndrome in Latin America Open
View article: Effectiveness and Toxicity of High-Dose Colistin Treatment in Patients with Multidrug-Resistant Gram-Negative Bacterial Infections
Effectiveness and Toxicity of High-Dose Colistin Treatment in Patients with Multidrug-Resistant Gram-Negative Bacterial Infections Open
High doses of colistin could be associated with a favorable clinical improvement in patients with MDRGN infections but has a limited effectiveness in extra-pulmonary infections, especially when a source-control procedure is not performed. …
View article: Ad Hoc Tools for Urban Renewal: The San Borja Remodeling in Santiago, Chile, 1967-1976
Ad Hoc Tools for Urban Renewal: The San Borja Remodeling in Santiago, Chile, 1967-1976 Open
Conceived, developed, and built in Santiago de Chile between 1967 and 1976, the San Borja Remodeling project was the flagship of the first years of the Urban Improvement Corporation (Corporación de Mejoramiento Urbano, CORMU), a State agen…
View article: Arsenic may be a carcinogenic determinant of a subset of gallbladder cancer: A pilot study
Arsenic may be a carcinogenic determinant of a subset of gallbladder cancer: A pilot study Open
View article: TL 729 ANÁLISIS DE LAS VÍAS BIOSINTÉTICAS DE ÁCIDOS BILIARES EN UN MODELO DE HEPATOCARCINOMA ASOCIADO A HÍGADO GRASO EN RATÓN
TL 729 ANÁLISIS DE LAS VÍAS BIOSINTÉTICAS DE ÁCIDOS BILIARES EN UN MODELO DE HEPATOCARCINOMA ASOCIADO A HÍGADO GRASO EN RATÓN Open
La enfermedad del hígado graso no alcohólico (HGNA) es una causa creciente de enfermedad hepática crónica en el mundo.El espectro de la enfermedad incluye cirrosis y (CHC).El rol de los ácidos biliares (BA) en la patogénesis del CHC asocia…
View article: Correction to: MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
Correction to: MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer Open
An amendment to this paper has been published and can be accessed via the original article.
View article: Helicobacter Pylori Infection Triggers PERK-Associated Survivin Loss in Gastric Tissue Samples and Cell Lines
Helicobacter Pylori Infection Triggers PERK-Associated Survivin Loss in Gastric Tissue Samples and Cell Lines Open
Infection by Helicobacter pylori (Hp) is the main risk factor associated with the development and progression of precancerous lesions to gastric cancer. Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated by endopl…
View article: The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer
The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer Open
Reprimo-like (RPRML) is an uncharacterized member of the Reprimo gene family. Here, we evaluated the role of RPRML and whether its regulation by DNA methylation is a potential non-invasive biomarker of gastric cancer. RPRML expression was …
View article: Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer
Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer Open
The diffuse-type of gastric cancer (DGC), molecularly associated with epithelial to mesenchymal transition (EMT), is increasing in incidence. Loss of E-cadherin expression is the hallmark of the EMT process and is largely due to the upregu…
View article: Autoimmune sequential overlap syndrome (autoimmune hepatitis/primary sclerosing cholangitis) and inflammatory bowel disease: three clinical cases
Autoimmune sequential overlap syndrome (autoimmune hepatitis/primary sclerosing cholangitis) and inflammatory bowel disease: three clinical cases Open
Inflammatory bowel disease (IBD) is related to different liver extraintestinal manifestations and occurs with or without a link to disease activity. Primary sclerosing cholangitis (PSC) is the most common hepatobiliary manifestation. Other…
View article: Histología en la Enfermedad Inflamatoria Intestinal
Histología en la Enfermedad Inflamatoria Intestinal Open
Resumen: La evaluación histológica de la Enfermedad Inflamatoria Intestinal (EII) tiene como finalidad corroborar el diagnóstico de EII. En este artículo revisaremos múltiples conceptos histológicos relacionados con EII. Definiremos los té…
View article: Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation
Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation Open
Background: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin-like growth factor-1 (IGF…
View article: Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer
Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer Open
TCGA RNAseq data analysis, evaluation of clinical samples and studies in cell lines identified an inverse relationship between Survivin and Reprimo. Elevated Survivin and reduced Reprimo protein expression correlated with poor patient prog…
View article: MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer Open
View article: Epstein-Barr Virus–Associated Gastric Carcinoma: The Americas’ Perspective
Epstein-Barr Virus–Associated Gastric Carcinoma: The Americas’ Perspective Open
Epstein-Barr virus (EBV) infection has been associated with different malignancies, and compelling evidence has shown that it may have a causative or at least contributing role in gastric carcinogenesis. EBV-associated gastric cancers have…
View article: The conundrum of the Epstein-Barr virus-associated gastric carcinoma in the Americas
The conundrum of the Epstein-Barr virus-associated gastric carcinoma in the Americas Open
Epstein-Barr virus-associated gastric carcinoma shows a higher prevalence in the Americas than Asia. We summarize all studies of Epstein Barr virus-associated gastric carcinoma in the Americas, focusing on host characteristics, environment…
View article: Reprimo tissue-specific expression pattern is conserved between zebrafish and human
Reprimo tissue-specific expression pattern is conserved between zebrafish and human Open
Reprimo (RPRM), a member of the RPRM gene family, is a tumor-suppressor gene involved in the regulation of the p53-mediated cell cycle arrest at G2/M. RPRM has been associated with malignant tumor progression and proposed as a potential bi…
View article: Additional file 3: Figure S3. of MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
Additional file 3: Figure S3. of MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer Open
miR-335 expression depends on the expression of its host gene, mesoderm specific transcript (MEST). A miR-335 log2-expression levels are shown in the y-axis. A linear model has been fit (blue regression line) using RNAseq data from 368 tum…
View article: Additional file 4: Figure S4. of MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
Additional file 4: Figure S4. of MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer Open
Transfection efficiency of human gastric cancer AGS and Hs 746T cell lines treated with miR-335 mimics/inhibitor. Increased or decreased expression of miR-335 in AGS and Hs 746T transfected with NC/miR-335 mimic or with NC/miR-335 inhibito…
View article: Additional file 2: Figure S2. of MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
Additional file 2: Figure S2. of MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer Open
Ingenuity Pathway Analysis (IPA) for network enrichment analysis identified metastasis and invasion downstream genes of miR-335. Network of nine significantly overexpressed (red) genes during miR-335 inhibition. MAP tool shows activation a…
View article: Additional file 1: Figure S1. of MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer
Additional file 1: Figure S1. of MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer Open
ΔCq of miR-335 in non-Asian gastric cancer cell lines. miR-335 was normalized by RNU6B. Data were transformed to logarithmic values (−log). Results indicate the mean ± SD (PPTX 56 kb)
View article: Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells Open
Tumor angiogenesis is widely recognized as one of the “hallmarks of cancer”. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and clinical cancer …
View article: Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer
Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer Open
Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC). The aim of this stu…
View article: Primary Sclerosing Cholangitis
Primary Sclerosing Cholangitis Open
Objectives: Liver biopsy diagnosis of primary sclerosing cholangitis (PSC) is difficult. We performed a detailed histologic analysis of PSC cases using novel bioinformatics analysis to identify histologic features that may be useful in its…
View article: Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers
Noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers Open
Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. It is a multifactorial disease, and its development depends on infection by…