Gonzalo Fernandez Lahore
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View article: Redox Regulation of LAT Enhances T Cell-Mediated Inflammation
Redox Regulation of LAT Enhances T Cell-Mediated Inflammation Open
The positional cloning of single nucleotide polymorphisms (SNPs) of the neutrophil cytosolic factor 1 (Ncf1) gene, advocating that a low oxidative burst drives autoimmune disease, demands an understanding of the underlying molecular causes…
View article: Redox Regulation of LAT Enhances T Cell-Mediated Inflammation
Redox Regulation of LAT Enhances T Cell-Mediated Inflammation Open
The positional cloning of single nucleotide polymorphisms (SNPs) of the neutrophil cytosolic factor 1 (Ncf1) gene, advocating that a low oxidative burst drives autoimmune disease, demands an understanding of the underlying molecular causes…
View article: Redox Regulation of Lat Enhances T Cell-Mediated Inflammation
Redox Regulation of Lat Enhances T Cell-Mediated Inflammation Open
View article: Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice
Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice Open
In the originally published article, the figure images for Figs. 4 and S4 were accidentally swapped with Figs. 5 and S5, respectively; the legends remain unchanged.The corrected figures and their legends are shown here.In addition, figure …
View article: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice
Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice Open
B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, we traced natural…
View article: Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells Open
View article: Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis
Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis Open
A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. It has been difficult to find safe ways to steer the targeting of natural regulatory antigen. Here, we show that the adm…
View article: Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells Open
Summary Dendritic cells (DCs) control the generation of self-reactive pathogenic T cells. Thus, DCs are considered attractive therapeutic targets for autoimmune diseases. Using single-cell and bulk transcriptional and metabolic analyses in…
View article: A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis Open
View article: Redox Regulation of Lat Enhances T Cell-Mediated Inflammation
Redox Regulation of Lat Enhances T Cell-Mediated Inflammation Open
View article: Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation Open
Chronic autoimmune diseases are associated with mutations in PTPN22, a modifier of T cell receptor (TCR) signaling. As with all protein tyrosine phosphatases, the activity of PTPN22 is redox regulated, but if or how such regulation can mod…
View article: Author response: Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
Author response: Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation Open
View article: Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis
Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis Open
Animal models for complex diseases are needed to position and analyze the function of interacting genes. Previous positional cloning identified Ncf1 and Clec4b to be major regulators of arthritis models in rats. Here, we investigate epista…
View article: Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation
Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation Open
Chronic autoimmune diseases are associated with mutations in PTPN22, a modifier of T cell receptor signaling. As with all protein tyrosine phosphatases the activity of PTPN22 is redox regulated, but if or how such regulation can modulate i…
View article: Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases
Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases Open
View article: Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics
Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics Open
Rheumatoid arthritis (RA) affects 0.5-1% of the population and is an important health and socioeconomic problem. RA has a high degree of heritability. Thus, extensive efforts have been made to better understand the genetic variability cont…
View article: Polymorphic estrogen receptor binding site causes CD2-dependent sex bias in the susceptibility to autoimmune diseases
Polymorphic estrogen receptor binding site causes CD2-dependent sex bias in the susceptibility to autoimmune diseases Open
Complex autoimmune diseases are sexually dimorphic. An interplay between predisposing genetics and sex-related factors likely determines the sex discrepancy in the immune response, but conclusive evidence is lacking regarding the underlyin…
View article: Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation Open
View article: Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases
Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases Open
Significance Conclusive identification of single genes contributing to complex autoimmune diseases has been challenging. Here, we positionally identify the vitamin D3 receptor gene ( Vdr ) as a driver of T cell-dependent inflammatory disea…