Gopinathan Anilkumar
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View article: Recent Advances in the Catalytic Synthesis of <i>α</i>‐Ketoamides
Recent Advances in the Catalytic Synthesis of <i>α</i>‐Ketoamides Open
α ‐Ketoamides are privileged chemical entities featuring a carbonyl group bonded to an amide. Bearing two pronucleophilic and two proelectrophilic sites, this structural scaffold exhibits distinct chemical properties and unparalleled biolo…
View article: Recent Developments and Perspectives in Palladium‐Catalyzed Multi‐Component Reactions
Recent Developments and Perspectives in Palladium‐Catalyzed Multi‐Component Reactions Open
Multi‐component reactions (MCRs) involve the reaction of three or more compounds to yield a single product. Typically, MCRs are eco‐friendly and atom‐economical processes, widely used to synthesize pharmaceutically relevant compounds with …
View article: Palladium‐Catalyzed Carbonylative Sonogashira Transformations: Advancements and Insights
Palladium‐Catalyzed Carbonylative Sonogashira Transformations: Advancements and Insights Open
Palladium‐catalyzed carbonylative reactions, used as a tool for the insertion of carbonyl group into organic moieties, is a synthetically useful transformation. Carbonylative Sonogashira coupling is a convenient approach for the synthesis …
View article: Manganese-Catalyzed <i>N</i>-Formylation of Anilines Using Oxalic Acid as CO Surrogate
Manganese-Catalyzed <i>N</i>-Formylation of Anilines Using Oxalic Acid as CO Surrogate Open
Formanilides are valuable synthetic intermediates and additives in the rubber industry. Manganese-catalyzed N-formylation of aniline using (COOH)2·2H2O represents a significant advancement in the synthesis of formanilides. This novel appro…
View article: Nickel-catalyzed Chan–Lam coupling: an efficient route to <i>N</i>-arylated 2-aminobenzothiazoles under ambient conditions
Nickel-catalyzed Chan–Lam coupling: an efficient route to <i>N</i>-arylated 2-aminobenzothiazoles under ambient conditions Open
A novel Ni-catalyzed Chan–Lam coupling of 2-aminobenzothiazoles to access synthetically valuable N -arylated 2-aminobenzothiazoles is reported. The key features are the ambient temperature, short reaction time and open-air conditions.
View article: An Overview of Palladium-Catalyzed N-alkylation Reactions
An Overview of Palladium-Catalyzed N-alkylation Reactions Open
N-Alkylation of amines is a vital reaction in the synthesis of numerous bioactive compounds and materials. Among transition metals, palladium has emerged as a particularly effective catalyst for these transformations. The unique advantages…
View article: Recent Advances and Prospects in Manganese‐Catalyzed C−H Activation
Recent Advances and Prospects in Manganese‐Catalyzed C−H Activation Open
C−H activation represents an interesting alternative to conventional cross‐coupling methods, avoiding the requirement of additional steps to introduce activating groups. Generally, Pd‐catalyzed reactions have been extensively employed for …
View article: An insight into structural, spectroscopic and nonlinear optical Application of a promising malononitrile derivative: (Z)-2-(3-chloro-3-(4-chlorophenyl)allylidene)malononitrile
An insight into structural, spectroscopic and nonlinear optical Application of a promising malononitrile derivative: (Z)-2-(3-chloro-3-(4-chlorophenyl)allylidene)malononitrile Open
Conjugated organic single crystals play a pivotal role as donor-acceptor molecules, showcasing nonlinear optical properties due to their unique molecular structure. In the present study, a novel functionalised allylidene malononitrile deri…
View article: A tandem strategy for the synthesis of 2-aminobenzothiazoles via manganese catalyzed C S bond formation
A tandem strategy for the synthesis of 2-aminobenzothiazoles via manganese catalyzed C S bond formation Open
The first manganese catalyzed tandem methodology for the synthesis of 2-aminobenzothiazoles from 2-bromophenyl isothiocyanate and differently substituted amines has been demonstrated. This protocol employs environmentally benign, cost-effe…
View article: Recent progress and prospects in the organocatalytic Morita–Baylis–Hillman reaction
Recent progress and prospects in the organocatalytic Morita–Baylis–Hillman reaction Open
The organocatalytic Morita–Baylis–Hillman (MBH) reaction, one of the most significant carbon–carbon bond formations involves the addition of α,β-unsaturated carbonyl compounds to activated alkenes to give α-methylene-β-hydroxycarbonyl comp…
View article: Advances in Biginelli reaction: A comprehensive review
Advances in Biginelli reaction: A comprehensive review Open
The Biginelli reaction, a conventional three‐component reaction provides 3,4‐dihydropyrimidin‐2(1H)‐ones/thiones via one‐pot acid catalyzed cyclocondensation of an aldehyde, a β‐keto ester, and urea or thiourea. Dihydropyrimidones are well…
View article: Synthesis of imidazo[1,2-a]pyridine derivatives and Zolimidine via a novel zinc/iodine-catalyzed Ortoleva-King type protocol
Synthesis of imidazo[1,2-a]pyridine derivatives and Zolimidine via a novel zinc/iodine-catalyzed Ortoleva-King type protocol Open
Imidazo[1,2-a]pyridines belong to a class of heterocyclic motifs possessing unique structural and pharmacological properties making them an interesting and promising domain in the fields of drug discovery and medicinal chemistry. These mol…
View article: Ruthenium-catalyzed hydroarylation reactions as the strategy towards the synthesis of alkylated arenes and substituted alkenes
Ruthenium-catalyzed hydroarylation reactions as the strategy towards the synthesis of alkylated arenes and substituted alkenes Open
Metal catalyzed hydroarylation reactions achieve C–C or C-heteroatom bonds in an atom economical and step economical manner. Here we cover the literature from 2016 to 2022 to summarize the recent advancements in Ru-catalyzed hydroarylation…
View article: Copper-catalyzed Sonogashira reactions: advances and perspectives since 2014
Copper-catalyzed Sonogashira reactions: advances and perspectives since 2014 Open
This review summarizes the recent advances and perspectives in copper catalyzed Sonogashira reaction covering both homogeneous and heterogeneous systems.
View article: Cu(<scp>ii</scp>)-catalyzed C–N coupling of 2-aminobenzothiazoles with boronic acids at room temperature
Cu(<span>ii</span>)-catalyzed C–N coupling of 2-aminobenzothiazoles with boronic acids at room temperature Open
A Cu( ii )-catalyzed, effective C–N coupling of 2-aminobenzothiazoles with boronic acids in acetonitrile under open vessel chemistry was achieved.
View article: Nickel/iodine-catalyzed synthesis of 2-arylimidazo[1,2-a]pyridines through Ortoleva-King type protocol
Nickel/iodine-catalyzed synthesis of 2-arylimidazo[1,2-a]pyridines through Ortoleva-King type protocol Open
A novel Ni-I2 catalytic system was introduced for the synthesis of 2-arylimidazo[1,2-a]pyridines from readily available arylmethyl ketones and 2-aminopyridines as the starting materials. The method uses efficient and cost-effective NiCl2·6…
View article: Recent advances and prospects in palladium-catalyzed Hiyama coupling reaction
Recent advances and prospects in palladium-catalyzed Hiyama coupling reaction Open
Palladium-catalyzed Hiyama coupling reaction became an astonishing area in organic chemistry.Palladium has been widely used as a catalyst in organic synthesis due to its good functional group tolerance and mild reaction condition.This revi…
View article: Nickel-catalyzed (hetero)aryl borylations: an update
Nickel-catalyzed (hetero)aryl borylations: an update Open
Aromatic organoboron compounds serve as important intermediates in synthetic organic chemistry.While the traditional electrophilic borylations using aromatic lithium or magnesium reagents had several limitations, transition metal catalyzed…
View article: Recent developments and trends in the iron- and cobalt-catalyzed Sonogashira reactions
Recent developments and trends in the iron- and cobalt-catalyzed Sonogashira reactions Open
Iron- and cobalt-catalyzed Sonogashira coupling reactions are becoming central areas of research in organic synthesis. Owing to their significant importance in the formation of carbon–carbon bonds, numerous green and nanoparticle protocols…
View article: Recent advances and perspectives in ruthenium-catalyzed cyanation reactions
Recent advances and perspectives in ruthenium-catalyzed cyanation reactions Open
The cyanation reaction has achieved rapid progress in recent times. The ability to exhibit multiple oxidation states increased the demand of ruthenium in the field of catalysis. These cyanation reactions have wide application in pharmacolo…
View article: Recent advances in ruthenium-catalyzed hydrosilylation of unsaturated compounds: Applications and mechanistic studies
Recent advances in ruthenium-catalyzed hydrosilylation of unsaturated compounds: Applications and mechanistic studies Open
Organosilanes have great importance in the field of synthetic organic chemistry. They are widely used as intermediates for the preparation of natural products, elastomers, resins and act as effective coupling partners in cross-coupling rea…
View article: A novel manganese/iodine-catalyzed Ortoleva-King type protocol for the synthesis of imidazo[1,2-a]pyridines and Zolimidine
A novel manganese/iodine-catalyzed Ortoleva-King type protocol for the synthesis of imidazo[1,2-a]pyridines and Zolimidine Open
The first manganese-iodine catalyzed Ortoleva-King type protocol for the synthesis of imidazo[1,2-a]pyridines has been established. This interesting methodology involves the use of less toxic, readily available and easy to handle MnO2 and …
View article: Applications of iron pincer complexes in hydrosilylation reactions
Applications of iron pincer complexes in hydrosilylation reactions Open
Iron pincer complexes are efficient in catalyzing various organic reactions with excellent selectivity and functional group tolerance at moderate reaction conditions. This review focuses on the applications of iron pincer complexes in hydr…
View article: A green protocol for the synthesis of N-aryl pyrroles: A modified Clauson-Kaas approach using zinc catalyst
A green protocol for the synthesis of N-aryl pyrroles: A modified Clauson-Kaas approach using zinc catalyst Open
The first zinc-catalyzed simple and convenient protocol for the synthesis of N-substituted pyrroles through a modified Clauson-Kaas reaction without co-catalyst, ligand, base and solvent has been described. N-substituted pyrroles were prep…
View article: Transition metal-catalyzed synthesis of spirooxindoles
Transition metal-catalyzed synthesis of spirooxindoles Open
Spirooxindoles are used as anticancer-, antiviral-, antimicrobial agents etc. The use of transition metals as catalysts for the synthesis of spirooxindoles is advancing rapidly. Here, we focus on recent advances in transition metal-catalyz…
View article: Applications of aryl-sulfinamides in the synthesis of N-heterocycles
Applications of aryl-sulfinamides in the synthesis of N-heterocycles Open
The review comprehends the usage of arylsulfinamides for the construction of diverse N-heterocycles like piperidines, pyrrolidines, aziridines, and their fused derivatives.