Goragot Wisedchaisri
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View article: Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7
Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7 Open
Voltage-gated sodium channels in peripheral nerves conduct nociceptive signals from nerve endings to the spinal cord. Mutations in voltage-gated sodium channel NaV1.7 are responsible for a number of severe inherited pain syndromes, includi…
View article: Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na <sub>V</sub> 1.7
Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na <sub>V</sub> 1.7 Open
Gain-of-function mutations in voltage-gated sodium channel Na V 1.7 cause severe inherited pain syndromes, including inherited erythromelalgia (IEM). The structural basis of these disease mutations, however, remains elusive. Here, we focus…
View article: Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites
Druggability of Voltage-Gated Sodium Channels—Exploring Old and New Drug Receptor Sites Open
Voltage-gated ion channels are important drug targets because they play crucial physiological roles in both excitable and non-excitable cells. About 15% of clinical drugs used for treating human diseases target ion channels. However, most …
View article: Broadband Tuning the Voltage Dependence of a Sodium Channel
Broadband Tuning the Voltage Dependence of a Sodium Channel Open
Voltage-gated sodium channels initiate action potentials in prokaryotes and in many eukaryotic cells, including vertebrate nerve and muscle. Their activation is steeply voltage-dependent, but it is unclear how the voltage sensitivity is se…